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Tbio
AK1
Adenylate kinase isoenzyme 1

Protein Summary
Description
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. This gene encodes an adenylate kinase enzyme involved in energy metabolism and homeostasis of cellular adenine nucleotide ratios in different intracellular compartments. This gene is highly expressed in skeletal muscle, brain and erythrocytes. Certain mutations in this gene resulting in a functionally inadequate enzyme are associated with a rare genetic disorder causing nonspherocytic hemolytic anemia. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373156
  • ENSP00000362249
  • ENSG00000106992
  • ENST00000373176
  • ENSP00000362271
  • ENST00000644144
  • ENSP00000494600

Symbol
  • HTL-S-58j
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.93
transcription factor perturbation
0.8
biological process
0.7
disease perturbation
0.68
small molecule perturbation
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 362.78   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 566   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 362.78   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 566   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
1
1
1
83
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
1
83
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
adenylate kinase 1
VGNC:13849
464756
Mouse
MGI:87977
11636
Dog
adenylate kinase 1
VGNC:37745
480712
Horse
adenylate kinase 1
VGNC:15194
100070413
Cow
adenylate kinase 1
VGNC:25770
280715
Species
Name
OMA
EggNOG
Inparanoid
Chimp
adenylate kinase 1
Mouse
Dog
adenylate kinase 1
Horse
adenylate kinase 1
Cow
adenylate kinase 1
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P00568-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (9)
Interconversion of nucleotide di- and triphosphates (R-HSA-499943)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Interconversion of nucleotide di- and triphosphates
Reactome
Metabolism
Reactome
Metabolism of nucleotides
Name
Explore in Pharos
Explore in Source
Interconversion of nucleotide di- and triphosphates
Metabolism
Metabolism of nucleotides
Protein-Protein Interactions (163)
1 – 10 of 163
ADK
Tchem
Family: Kinase
Novelty: 0.00196435
Score: 0.955
Data Source: STRINGDB
APRT
Tbio
Family: Enzyme
Novelty: 0.00483077
Score: 0.95
Data Source: STRINGDB
TPK1
Tbio
Family: Kinase
Novelty: 0.00899463
Score: 0.94
Data Source: STRINGDB
ADSL
Tbio
Family: Enzyme
Novelty: 0.0028496
Score: 0.938
Data Source: STRINGDB
ENTPD2
Tchem
Family: Enzyme
Novelty: 0.00132093
Score: 0.937
Data Source: STRINGDB
ATP5F1A
Tbio
Family: Enzyme
Novelty: 0.01052213
Score: 0.93
Data Source: STRINGDB
MT-ATP6
Tbio
Family: Enzyme
Novelty: 0.00104191
Score: 0.921
Data Source: STRINGDB
ATP5F1C
Tbio
Family: Enzyme
Novelty: 0.07666564
Score: 0.921
Data Source: STRINGDB
ATP5PD
Tbio
Family: Enzyme
Novelty: 0.0730514
Score: 0.917
Data Source: STRINGDB
ATP5F1D
Tbio
Family: Enzyme
Novelty: 0.07296539
Score: 0.916
Data Source: STRINGDB
Publication Statistics
PubMed Score  362.78

PubMed score by year
PubTator Score  198.25

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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