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Tchem
PGK1
Phosphoglycerate kinase 1

Protein Summary
Description
In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein) (PubMed:2324090). May play a role in sperm motility (PubMed:26677959). The protein encoded by this gene is a glycolytic enzyme that catalyzes the conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate. The encoded protein may also act as a cofactor for polymerase alpha. Additionally, this protein is secreted by tumor cells where it participates in angiogenesis by functioning to reduce disulfide bonds in the serine protease, plasmin, which consequently leads to the release of the tumor blood vessel inhibitor angiostatin. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Deficiency of the enzyme is associated with a wide range of clinical phenotypes hemolytic anemia and neurological impairment. Pseudogenes of this gene have been defined on chromosomes 19, 21 and ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373316
  • ENSP00000362413
  • ENSG00000102144
  • ENST00000644362
  • ENSP00000496140

Symbol
  • PGKA
  • PGKA
  • MIG10
  • HEL-S-68p
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
1
transcription factor perturbation
1
interacting protein
0.99
hub protein
0.97


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 798.48   (req: < 5)
Gene RIFs: 55   (req: <= 3)
Antibodies: 438   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 798.48   (req: >= 5)
Gene RIFs: 55   (req: > 3)
Antibodies: 438   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 8
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
60.7
mean platelet volume
1
1
1
31.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
60.7
mean platelet volume
1
31.7
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phosphoglycerate kinase 1
VGNC:1208
473678
Macaque
phosphoglycerate kinase 1
706325
Mouse
MGI:97555
18655
Rat
RGD:619878
24644
Dog
phosphoglycerate kinase 1
VGNC:49941
480964
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phosphoglycerate kinase 1
Macaque
phosphoglycerate kinase 1
Mouse
Rat
Dog
phosphoglycerate kinase 1
Protein Structure (25 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P00558-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 25
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (22)
Gluconeogenesis (R-HSA-70263)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gluconeogenesis
Reactome
Glucose metabolism
Reactome
Glycolysis
Reactome
Metabolism
Reactome
Metabolism of carbohydrates
Name
Explore in Pharos
Explore in Source
Gluconeogenesis
Glucose metabolism
Glycolysis
Metabolism
Metabolism of carbohydrates
Gene Ontology Terms (21)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
CAFA
Inferred from Mutant Phenotype (IMP)
CAFA
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (321)
1 – 10 of 321
PGK2
Tbio
Family: Kinase
Novelty: 0.00832045
p_int: 0.999678996
p_ni: 0.000321004
Score: 0.853
Data Source: BioPlex,STRINGDB
TPI1
Tbio
Family: Enzyme
Novelty: 0.00074652
Score: 0.999
Data Source: STRINGDB
GAPDH
Tchem
Family: Enzyme
Novelty: 0.00005849
Score: 0.998
Data Source: STRINGDB
ENO1
Tchem
Family: Enzyme
Novelty: 0.00109178
Score: 0.991
Data Source: STRINGDB
PGAM1
Tbio
Family: Enzyme
Novelty: 0.0111272
Score: 0.99
Data Source: STRINGDB
PGAM4
Tbio
Family: Enzyme
Novelty: 0.03784125
Score: 0.987
Data Source: STRINGDB
GAPDHS
Tbio
Family: Enzyme
Novelty: 0.00885959
Score: 0.984
Data Source: STRINGDB
PGAM2
Tbio
Family: Enzyme
Novelty: 0.02438933
Score: 0.983
Data Source: STRINGDB
BPGM
Tbio
Family: Enzyme
Novelty: 0.03437401
Score: 0.973
Data Source: STRINGDB
GPI
Tbio
Family: Enzyme
Novelty: 0.00095404
Score: 0.957
Data Source: STRINGDB
Publication Statistics
PubMed Score  798.48

PubMed score by year
PubTator Score  226.18

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer