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Tbio
MOS
Proto-oncogene serine/threonine-protein kinase mos

Protein Summary
Description
MOS is a serine/threonine kinase that activates the MAP kinase cascade through direct phosphorylation of the MAP kinase activator MEK (MAP2K1; MIM 176872) (Prasad et al., 2008 [PubMed 18246541]).[supplied by OMIM, Jul 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311923
  • ENSP00000310722
  • ENSG00000172680

Symbol
  • MSV
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
biological process
0.83
cell type or tissue
0.81
gene perturbation
0.62
protein domain
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.22   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 269   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.22   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 269   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (67)
1 – 10 of 67
FKBP5
Tchem
Family:  Enzyme
Novelty:  0.00214511
p_int:  0.996563191
p_ni:  0.003436809
Score:  0.312
Data Source:  BioPlex,STRINGDB
PPP2R5E
Tbio
Family:  Enzyme
Novelty:  0.05974697
p_int:  0.986772243
p_ni:  0.013227489
p_wrong:  2.68e-7
Score:  0.283
Data Source:  BioPlex,STRINGDB
CLUH
Tbio
Novelty:  0.14027296
p_int:  0.963955071
p_ni:  0.036044928
p_wrong:  2e-9
Score:  0.221
Data Source:  BioPlex,STRINGDB
MINDY3
Tbio
Novelty:  0.02865765
p_int:  0.954074354
p_ni:  0.045925646
Score:  0.163
Data Source:  BioPlex,STRINGDB
PPP2R5A
Tchem
Family:  Enzyme
Novelty:  0.03073487
p_int:  0.870393202
p_ni:  0.000089645
p_wrong:  0.129517154
Score:  0.426
Data Source:  BioPlex,STRINGDB
BIRC6
Tbio
Novelty:  0.01187953
p_int:  0.86678016
p_ni:  0.13321984
Score:  0.361
Data Source:  BioPlex,STRINGDB
MAP2K2
Tclin
Family:  Kinase
Novelty:  0.00706525
Score:  0.888
Data Source:  STRINGDB
MAP2K1
Tclin
Family:  Kinase
Novelty:  0.0005278
Score:  0.881
Data Source:  STRINGDB
PKMYT1
Tchem
Family:  Kinase
Novelty:  0.03025516
Score:  0.848
Data Source:  STRINGDB
HSP90AB1
Tchem
Novelty:  0.00907961
Score:  0.845
Data Source:  STRINGDB
Pathways (37)
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Oocyte meiosis
KEGG
Regulation of actin cytoskeleton
KEGG
Progesterone-mediated oocyte maturation
Name
Explore in Pharos
Explore in Source
Oocyte meiosis
Regulation of actin cytoskeleton
Progesterone-mediated oocyte maturation
Gene Ontology Terms (13)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
3
4
7
97.9
body height
5
4
5
96
BMI-adjusted hip circumference
3
6
6
77.2
platelet crit
1
1
1
64
heel bone mineral density
2
1
2
59.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
7
97.9
body height
5
96
BMI-adjusted hip circumference
6
77.2
platelet crit
1
64
heel bone mineral density
2
59.5
Find similar targets by:
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
MOS proto-oncogene, serine/threonine kinase
VGNC:14573
472772
Macaque
MOS proto-oncogene, serine/threonine kinase
698921
Mouse
MGI:97052
17451
Rat
RGD:3103
24559
Dog
MOS proto-oncogene, serine/threonine kinase
VGNC:43323
486959
Species
Name
OMA
EggNOG
Inparanoid
Chimp
MOS proto-oncogene, serine/threonine kinase
Macaque
MOS proto-oncogene, serine/threonine kinase
Mouse
Rat
Dog
MOS proto-oncogene, serine/threonine kinase
Publication Statistics
PubMed Score 13.22
PubMed score by year
PubTator Score 844.15
PubTator score by year
Patents
Patents by year