PNP
Purine nucleoside phosphorylase
Protein Classes
Protein Summary
The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. This gene encodes an enzyme which reversibly catalyzes the phosphorolysis of purine nucleosides. The enzyme is trimeric, containing three identical subunits. Mutations which result in nucleoside phosphorylase deficiency result in defective T-cell (cell-mediated) immunity but can also affect B-cell immunity and antibody responses. Neurologic disorders may also be apparent in patients with immune defects. A known polymorphism at aa position 51 that does not affect enzyme activity has been described. A pseudogene has been identified on chromosome 2. [provided by RefSeq, Jul 2008]
- ENST00000361505
- ENSP00000354532
- ENSG00000198805
- NP
- NP
- PUNP
- PRO1837
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 1 | ||
kinase perturbation | 0.99 | ||
transcription factor perturbation | 0.96 | ||
biological process | 0.95 | ||
virus perturbation | 0.95 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 461.69 (req: < 5)
Gene RIFs: 33 (req: <= 3)
Antibodies: 290 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 461.69 (req: >= 5)
Gene RIFs: 33 (req: > 3)
Antibodies: 290 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 18
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 194
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
Active Ligands (194)
1 – 10 of 194
GWAS Traits (1)
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
high density lipoprotein cholesterol measurement | 1 | 1 | 1 | 6.3 | |||||
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
high density lipoprotein cholesterol measurement | 1 | 6.3 | |||||
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | purine nucleoside phosphorylase | VGNC:3356 | 737850 | |||||
Mouse | MGI:3712328 | 667034 | ||||||
Rat | RGD:1597189 | 290029 | ||||||
Dog | purine nucleoside phosphorylase | VGNC:44751 | 475393 | |||||
Horse | purine nucleoside phosphorylase-like | 100072592 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | purine nucleoside phosphorylase | |||||
Mouse | ||||||
Rat | ||||||
Dog | purine nucleoside phosphorylase | |||||
Horse | purine nucleoside phosphorylase-like | |||||
Protein Structure (36 Structures, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 5 of 36
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (32)
Reactome (9)
KEGG (4)
PathwayCommons (16)
UniProt (1)
WikiPathways (2)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 9
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Immune System | ||||
Reactome | Innate Immune System | ||||
Reactome | Metabolism | ||||
Reactome | Metabolism of nucleotides | ||||
Reactome | Neutrophil degranulation | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Immune System | ||||
Innate Immune System | ||||
Metabolism | ||||
Metabolism of nucleotides | ||||
Neutrophil degranulation | ||||
Gene Ontology Terms (27)
Functions (5)
Components (9)
Processes (13)
Items per page:
10
1 – 5 of 5
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Protein-Protein Interactions (137)
1 – 10 of 137
ADA
Family: Enzyme
Novelty: 0.00072339
Score: 0.996
Data Source: STRINGDB
ADK
Family: Kinase
Novelty: 0.00196435
Score: 0.989
Data Source: STRINGDB
GDA
Family: Enzyme
Novelty: 0.01846276
Score: 0.984
Data Source: STRINGDB
APRT
Family: Enzyme
Novelty: 0.00483077
Score: 0.984
Data Source: STRINGDB
UPP1
Family: Enzyme
Novelty: 0.01384975
Score: 0.979
Data Source: STRINGDB
CDA
Family: Enzyme
Novelty: 0.00280981
Score: 0.976
Data Source: STRINGDB
HPRT1
Family: Enzyme
Novelty: 0.00032232
Score: 0.974
Data Source: STRINGDB
NMRK1
Family: Kinase
Novelty: 0.04761376
Score: 0.969
Data Source: STRINGDB
PGM2
Family: Enzyme
Novelty: 0.00922421
Score: 0.964
Data Source: STRINGDB
DCK
Family: Kinase
Novelty: 0.00201831
Score: 0.963
Data Source: STRINGDB
Publication Statistics
PubMed Score 461.69
PubMed score by year
PubTator Score 352.22
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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UniProt Keyword