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Tclin
PNP
Purine nucleoside phosphorylase

Protein Summary
Description
The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. This gene encodes an enzyme which reversibly catalyzes the phosphorolysis of purine nucleosides. The enzyme is trimeric, containing three identical subunits. Mutations which result in nucleoside phosphorylase deficiency result in defective T-cell (cell-mediated) immunity but can also affect B-cell immunity and antibody responses. Neurologic disorders may also be apparent in patients with immune defects. A known polymorphism at aa position 51 that does not affect enzyme activity has been described. A pseudogene has been identified on chromosome 2. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361505
  • ENSP00000354532
  • ENSG00000198805

Symbol
  • NP
  • NP
  • PUNP
  • PRO1837
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
0.99
transcription factor perturbation
0.96
biological process
0.95
virus perturbation
0.95


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 461.69   (req: < 5)
Gene RIFs: 33   (req: <= 3)
Antibodies: 290   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 461.69   (req: >= 5)
Gene RIFs: 33   (req: > 3)
Antibodies: 290   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 194
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
forodesine
chemical structure image
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
1
1
1
6.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
1
6.3
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
purine nucleoside phosphorylase
VGNC:3356
737850
Mouse
MGI:3712328
667034
Rat
RGD:1597189
290029
Dog
purine nucleoside phosphorylase
VGNC:44751
475393
Horse
purine nucleoside phosphorylase-like
100072592
Species
Name
OMA
EggNOG
Inparanoid
Chimp
purine nucleoside phosphorylase
Mouse
Rat
Dog
purine nucleoside phosphorylase
Horse
purine nucleoside phosphorylase-like
Protein Structure (36 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P00491-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 36
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (32)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Metabolism
Reactome
Metabolism of nucleotides
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Metabolism
Metabolism of nucleotides
Neutrophil degranulation
Protein-Protein Interactions (137)
1 – 10 of 137
ADA
Tclin
Family: Enzyme
Novelty: 0.00072339
Score: 0.996
Data Source: STRINGDB
ADK
Tchem
Family: Kinase
Novelty: 0.00196435
Score: 0.989
Data Source: STRINGDB
GDA
Tbio
Family: Enzyme
Novelty: 0.01846276
Score: 0.984
Data Source: STRINGDB
APRT
Tbio
Family: Enzyme
Novelty: 0.00483077
Score: 0.984
Data Source: STRINGDB
UPP1
Tchem
Family: Enzyme
Novelty: 0.01384975
Score: 0.979
Data Source: STRINGDB
CDA
Tchem
Family: Enzyme
Novelty: 0.00280981
Score: 0.976
Data Source: STRINGDB
HPRT1
Tchem
Family: Enzyme
Novelty: 0.00032232
Score: 0.974
Data Source: STRINGDB
NMRK1
Tbio
Family: Kinase
Novelty: 0.04761376
Score: 0.969
Data Source: STRINGDB
PGM2
Tbio
Family: Enzyme
Novelty: 0.00922421
Score: 0.964
Data Source: STRINGDB
DCK
Tchem
Family: Kinase
Novelty: 0.00201831
Score: 0.963
Data Source: STRINGDB
Publication Statistics
PubMed Score  461.69

PubMed score by year
PubTator Score  352.22

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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