PNP
Purine nucleoside phosphorylase
Protein Summary
The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. This gene encodes an enzyme which reversibly catalyzes the phosphorolysis of purine nucleosides. The enzyme is trimeric, containing three identical subunits. Mutations which result in nucleoside phosphorylase deficiency result in defective T-cell (cell-mediated) immunity but can also affect B-cell immunity and antibody responses. Neurologic disorders may also be apparent in patients with immune defects. A known polymorphism at aa position 51 that does not affect enzyme activity has been described. A pseudogene has been identified on chromosome 2. [provided by RefSeq, Jul 2008]
- ENST00000361505
- ENSP00000354532
- ENSG00000198805
- NP
- NP
- PUNP
- PRO1837
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 1 | ||
kinase perturbation | 0.99 | ||
transcription factor perturbation | 0.96 | ||
biological process | 0.95 | ||
virus perturbation | 0.95 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 464.29 (req: < 5)
Gene RIFs: 33 (req: <= 3)
Antibodies: 290 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 464.29 (req: >= 5)
Gene RIFs: 33 (req: > 3)
Antibodies: 290 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 18
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 199
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (1)
Active Ligands (199)
Protein-Protein Interactions (137)
Nearest Tclin Targets
Pathways (32)
Reactome (9)
KEGG (4)
PathwayCommons (16)
UniProt (1)
WikiPathways (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Immune System | ||||
Reactome | Innate Immune System | ||||
Reactome | Metabolism | ||||
Reactome | Metabolism of nucleotides | ||||
Reactome | Neutrophil degranulation | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Immune System | ||||
Innate Immune System | ||||
Metabolism | ||||
Metabolism of nucleotides | ||||
Neutrophil degranulation | ||||
Viral Interactions (0)
Gene Ontology Terms (27)
Functions (5)
Components (9)
Processes (13)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Disease Associations ()
GWAS Traits (7)
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mitochondrial DNA measurement | 1 | 1 | 1 | 73.6 | |||||
metabolite measurement | 1 | 1 | 1 | 65.6 | |||||
aspartate aminotransferase measurement | 2 | 1 | 1 | 6.8 | 62.1 | ||||
1 | 1 | 0 | 1.6 | 27.3 | |||||
serum alanine aminotransferase measurement | 1 | 1 | 0 | 5.6 | 21.5 | ||||
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mitochondrial DNA measurement | 1 | 73.6 | |||||
metabolite measurement | 1 | 65.6 | |||||
aspartate aminotransferase measurement | 1 | 6.8 | 62.1 | ||||
0 | 1.6 | 27.3 | |||||
serum alanine aminotransferase measurement | 0 | 5.6 | 21.5 | ||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | purine nucleoside phosphorylase | VGNC:3356 | 737850 | |||||
Mouse | MGI:3712328 | 667034 | ||||||
Rat | RGD:1597189 | 290029 | ||||||
Dog | purine nucleoside phosphorylase | VGNC:44751 | 475393 | |||||
Horse | purine nucleoside phosphorylase-like | 100072592 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | purine nucleoside phosphorylase | |||||
Mouse | ||||||
Rat | ||||||
Dog | purine nucleoside phosphorylase | |||||
Horse | purine nucleoside phosphorylase-like | |||||
Publication Statistics
PubMed Score 464.29
PubMed score by year
PubTator Score 352.22
PubTator score by year
Related Publications
Text Mined References (65)
GeneRif Annotations (33)
Items per page:
0 of 0
PMID | Year | Title |
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