Tchem F13A1 Coagulation factor XIII A chain

Protein Summary

Description

Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P00488
• Q59HA7
• Q8N6X2
• Q96P24
• Q9BX29
• Coagulation factor XIIIa

Gene Name

• F13A1

Ensembl ID

• ENST00000264870
• ENSP00000264870
• ENSG00000124491

Symbol

• F13A
• F13A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
trait	0.97
gene perturbation	0.96
biological term	0.93
protein domain	0.92
disease	0.83

Protein Classes

PANTHER Classes

Protein / Transferase / Acyltransferase / Coagulation Factor Xiii A Chain

DTO Classes

Protein / Enzyme / Transferase / Acyltransferase / Coagulation Factor Xiii A Chain

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 175.62   (req: < 5)

Gene RIFs: 198   (req: <= 3)

Antibodies: 1204   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 175.62   (req: >= 5)

Gene RIFs: 198   (req: > 3)

Antibodies: 1204   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 72

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0