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Tchem
OTC
Ornithine carbamoyltransferase, mitochondrial

Protein Summary
Description
This nuclear gene encodes a mitochondrial matrix enzyme. Missense, nonsense, and frameshift mutations in this enzyme lead to ornithine transcarbamylase deficiency, which causes hyperammonemia. Since the gene for this enzyme maps close to that for Duchenne muscular dystrophy, it may play a role in that disease also. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000039007
  • ENSP00000039007
  • ENSG00000036473

Symbol
  • OCTD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.78
gene perturbation
0.76
cellular component
0.66
virus perturbation
0.64
cell line
0.58


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 181.64   (req: < 5)
Gene RIFs: 37   (req: <= 3)
Antibodies: 598   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 181.64   (req: >= 5)
Gene RIFs: 37   (req: > 3)
Antibodies: 598   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (140)
TUBB1
Tclin
Novelty:  0.02806117
p_int:  0.999273102
p_ni:  0.000726898
Data Source:  BioPlex
POLG
Tchem
Family:  Enzyme
Novelty:  0.00172189
p_int:  0.997340269
p_ni:  0.002659731
Score:  0.258
Data Source:  BioPlex,STRINGDB
NIPSNAP3A
Tdark
Novelty:  0.45687717
p_int:  0.957064983
p_ni:  0.042935017
Score:  0.173
Data Source:  BioPlex,STRINGDB
NDUFAF7
Tbio
Family:  Enzyme
Novelty:  0.24691414
p_int:  0.954153527
p_ni:  0.045846366
p_wrong:  1.07e-7
Data Source:  BioPlex
FDXR
Tbio
Family:  Enzyme
Novelty:  0.00171588
p_int:  0.943082124
p_ni:  0.056917876
Score:  0.222
Data Source:  BioPlex,STRINGDB
ATPAF1
Tbio
Family:  Enzyme
Novelty:  0.04032579
p_int:  0.894285901
p_ni:  0.105714099
Score:  0.188
Data Source:  BioPlex,STRINGDB
GLS
Tchem
Family:  Enzyme
Novelty:  0.00321692
p_int:  0.888820321
p_ni:  0.111179676
p_wrong:  3e-9
Score:  0.353
Data Source:  BioPlex,STRINGDB
NARS2
Tbio
Family:  Enzyme
Novelty:  0.01879317
p_int:  0.888534169
p_ni:  0.11146569
p_wrong:  1.41e-7
Score:  0.238
Data Source:  BioPlex,STRINGDB
A6ZKI3
Tbio
Novelty:  0.20316911
p_int:  0.851880043
p_ni:  0.148118739
p_wrong:  0.000001218
Score:  0.173
Data Source:  BioPlex,STRINGDB
HARS2
Tbio
Family:  Enzyme
Novelty:  0.00230399
p_int:  0.790942277
p_ni:  0.208788369
p_wrong:  0.000269354
Data Source:  BioPlex
Pathways (21)
Metabolism (R-HSA-1430728)

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Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Reactome
Mitochondrial protein import
Reactome
Protein localization
Reactome
Urea cycle
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of amino acids and derivatives
Mitochondrial protein import
Protein localization
Urea cycle
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ornithine carbamoyltransferase
VGNC:14706
738893
Macaque
ornithine carbamoyltransferase
698428
Mouse
MGI:97448
18416
Rat
RGD:3236
25611
Dog
ornithine carbamoyltransferase
VGNC:44174
480878
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ornithine carbamoyltransferase
Macaque
ornithine carbamoyltransferase
Mouse
Rat
Dog
ornithine carbamoyltransferase
Publication Statistics
PubMed Score 181.64
PubMed score by year
PubTator Score 926.22
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title