Pharos : Target Details

Tchem

Protein Summary

Description

This nuclear gene encodes a mitochondrial matrix enzyme. Missense, nonsense, and frameshift mutations in this enzyme lead to ornithine transcarbamylase deficiency, which causes hyperammonemia. Since the gene for this enzyme maps close to that for Duchenne muscular dystrophy, it may play a role in that disease also. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

Gene Name

Ensembl ID

ENST00000039007
ENSP00000039007
ENSG00000036473

Symbol

OCTD

Illumination Graph

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.78

gene perturbation	0.76

cellular component	0.66

virus perturbation	0.64

cell line	0.58

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 181.64 (req: < 5)

View Publications

Gene RIFs: 37 (req: <= 3)

View Gene RIFs

Antibodies: 598 (req: <= 50)

View Antibodies

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 181.64 (req: >= 5)

Gene RIFs: 37 (req: > 3)

Antibodies: 598 (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

View GO Terms

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Explore Active Ligands

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Related Tools (3)

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Go To Tool

Approved Drugs (0)

No approved drugs found

Active Ligands (1)

Explore Active Ligands

1 – 1 of 1

2-Amino-5-(2-phosphono-acetylamino)-pentanoic acid

Protein-Protein Interactions (140)

Explore Interacting Targets

1 – 10 of 140

See Interactions on String-DB

TUBB1

Tclin

Novelty: 0.02806117

p_int: 0.999273102

p_ni: 0.000726898

Data Source: BioPlex

POLG

Tchem

Family: Enzyme

Novelty: 0.00172189

p_int: 0.997340269

p_ni: 0.002659731

Score: 0.258

Data Source: BioPlex,STRINGDB

NIPSNAP3A

Tdark

Novelty: 0.45687717

p_int: 0.957064983

p_ni: 0.042935017

Score: 0.173

Data Source: BioPlex,STRINGDB

NDUFAF7

Tbio

Family: Enzyme

Novelty: 0.24691414

p_int: 0.954153527

p_ni: 0.045846366

p_wrong: 1.07e-7

Data Source: BioPlex

FDXR

Tbio

Family: Enzyme

Novelty: 0.00171588

p_int: 0.943082124

p_ni: 0.056917876

Score: 0.222

Data Source: BioPlex,STRINGDB

ATPAF1

Tbio

Family: Enzyme

Novelty: 0.04032579

p_int: 0.894285901

p_ni: 0.105714099

Score: 0.188

Data Source: BioPlex,STRINGDB

GLS

Tchem

Family: Enzyme

Novelty: 0.00321692

p_int: 0.888820321

p_ni: 0.111179676

p_wrong: 3e-9

Score: 0.353

Data Source: BioPlex,STRINGDB

NARS2

Tbio

Family: Enzyme

Novelty: 0.01879317

p_int: 0.888534169

p_ni: 0.11146569

p_wrong: 1.41e-7

Score: 0.238

Data Source: BioPlex,STRINGDB

A6ZKI3

Tbio

Novelty: 0.20316911

p_int: 0.851880043

p_ni: 0.148118739

p_wrong: 0.000001218

Score: 0.173

Data Source: BioPlex,STRINGDB

HARS2

Tbio

Family: Enzyme

Novelty: 0.00230399

p_int: 0.790942277

p_ni: 0.208788369

p_wrong: 0.000269354

Data Source: BioPlex

Nearest Tclin Targets (1)

Explore Nearest Tclin Targets

Upstream (1)

1 – 1 of 1

CPS1

Tclin

Family: Enzyme

KEGG Distance: 1

Common Pathways: 3

1: Metabolic pathways

2: Biosynthesis of amino acids

3: Arginine biosynthesis

Pathways (21)

Reactome (5)

KEGG (3)

PathwayCommons (6)

UniProt (1)

WikiPathways (6)

Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets

Items per page:

1 – 5 of 5

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Metabolism	2112 targets	R-HSA-1430728

Reactome	Metabolism of amino acids and derivatives	373 targets	R-HSA-71291

Reactome	Mitochondrial protein import	65 targets	R-HSA-1268020

Reactome	Protein localization	165 targets	R-HSA-9609507

Reactome	Urea cycle	10 targets	R-HSA-70635

Name	Explore in Pharos	Explore in Source
Metabolism	2112 targets	R-HSA-1430728

Metabolism of amino acids and derivatives	373 targets	R-HSA-71291

Mitochondrial protein import	65 targets	R-HSA-1268020

Protein localization	165 targets	R-HSA-9609507

Urea cycle	10 targets	R-HSA-70635

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (19)

Functions (4)

Components (3)

Processes (12)

Find Similar Targets

Items per page:

1 – 4 of 4

GO Term	Evidence	Assigned by
ornithine carbamoyltransferase activity	Inferred from Direct Assay (IDA)	BHF-UCL

amino acid binding	Inferred from Electronic Annotation (IEA)	Ensembl

phosphate ion binding	Inferred from Electronic Annotation (IEA)	Ensembl

phospholipid binding	Inferred from Electronic Annotation (IEA)	Ensembl

Disease Associations (null)

No disease associations found

GWAS Traits (0)

No GWAS traits found

Find similar targets by:

UniProt Keyword

Find Similar Targets

No Header	No Header
3D-structure

Acetylation

Amino-acid biosynthesis

Arginine biosynthesis

Complete proteome

Disease mutation

Mitochondrion

Phosphoprotein

Polymorphism

Reference proteome

MGI Phenotype

Find Similar Targets

No Header	No Header
behavior/neurological phenotype

cellular phenotype

endocrine/exocrine gland phenotype

growth/size/body region phenotype

homeostasis/metabolism phenotype

immune system phenotype

integument phenotype

liver/biliary system phenotype

mortality/aging

nervous system phenotype

IDG Resources

No IDG generated resources found

Orthologs (15)

1 – 5 of 15

Species	Name	Source ID	Gene ID
Chimp	ornithine carbamoyltransferase	VGNC:14706	738893

Macaque	ornithine carbamoyltransferase		698428

Mouse	ornithine transcarbamylase	MGI:97448	18416

Rat	ornithine carbamoyltransferase	RGD:3236	25611

Dog	ornithine carbamoyltransferase	VGNC:44174	480878

Species	Name	OMA	EggNOG	Inparanoid
Chimp	ornithine carbamoyltransferase

Macaque	ornithine carbamoyltransferase

Mouse	ornithine transcarbamylase

Rat	ornithine carbamoyltransferase

Dog	ornithine carbamoyltransferase

Publication Statistics

PubMed Score 181.64

PubMed score by year

PubTator Score 926.22

PubTator score by year

Related Publications

Text Mined References (104)

GeneRif Annotations (37)

Items per page:

0 of 0

PMID	Year	Title