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Tbio
F8
Coagulation factor VIII

Protein Summary
Description
Factor VIII, along with calcium and phospholipid, acts as a cofactor for F9/factor IXa when it converts F10/factor X to the activated form, factor Xa. This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000330287
  • ENSP00000327895
  • ENSG00000185010
  • ENST00000360256
  • ENSP00000353393

Symbol
  • F8C
  • AHF
  • F8B
  • F8C
  • HEMA
  • FVIII
  • DXS1253E
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
protein domain
0.99
disease
0.7
cellular component
0.65
interacting protein
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4730.93   (req: < 5)
Gene RIFs: 438   (req: <= 3)
Antibodies: 965   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4730.93   (req: >= 5)
Gene RIFs: 438   (req: > 3)
Antibodies: 965   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (184)
VWF
Tclin
Novelty:  0.00009007
Score:  0.998
Data Source:  Reactome,STRINGDB
F9
Tchem
Family:  Enzyme
Novelty:  0.00032127
Score:  0.992
Data Source:  Reactome,STRINGDB
F2
Tclin
Family:  Enzyme
Novelty:  0.00004833
Score:  0.99
Data Source:  Reactome,STRINGDB
F11
Tchem
Family:  Enzyme
Novelty:  0.00169618
Score:  0.988
Data Source:  STRINGDB
F10
Tclin
Family:  Enzyme
Novelty:  0.00063008
Score:  0.984
Data Source:  Reactome,STRINGDB
MCFD2
Tbio
Novelty:  0.0402944
Score:  0.983
Data Source:  Reactome,STRINGDB
SERPINC1
Tclin
Novelty:  0.00008721
Score:  0.979
Data Source:  STRINGDB
LMAN1
Tbio
Novelty:  0.00595367
Score:  0.976
Data Source:  Reactome,STRINGDB
PLG
Tclin
Family:  Enzyme
Novelty:  0.00004806
Score:  0.966
Data Source:  STRINGDB
PROC
Tchem
Family:  Enzyme
Novelty:  0.00440723
Score:  0.96
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (234)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
COPII-mediated vesicle transport
Reactome
Cargo concentration in the ER
Reactome
Common Pathway of Fibrin Clot Formation
Reactome
ER to Golgi Anterograde Transport
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
COPII-mediated vesicle transport
Cargo concentration in the ER
Common Pathway of Fibrin Clot Formation
ER to Golgi Anterograde Transport
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
53.3
hemoglobin measurement
1
1
1
50.6
erythrocyte count
1
1
1
50.6
hematocrit
1
1
1
50.6
leukocyte count
1
1
1
50.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
53.3
hemoglobin measurement
1
50.6
erythrocyte count
1
50.6
hematocrit
1
50.6
leukocyte count
1
50.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
coagulation factor VIII
VGNC:7458
473838
Macaque
coagulation factor VIII
100424151
Mouse
MGI:88383
14069
Rat
RGD:727845
302470
Dog
coagulation factor VIII
VGNC:40553
403875
Species
Name
OMA
EggNOG
Inparanoid
Chimp
coagulation factor VIII
Macaque
coagulation factor VIII
Mouse
Rat
Dog
coagulation factor VIII
Publication Statistics
PubMed Score 4730.93
PubMed score by year
PubTator Score 3199.42
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title