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Tchem
SOD1
Superoxide dismutase [Cu-Zn]

Protein Summary
Description
Destroys radicals which are normally produced within the cells and which are toxic to biological systems. The protein encoded by this gene binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000270142
  • ENSP00000270142
  • ENSG00000142168

Symbol
  • ALS
  • SOD
  • ALS1
  • IPOA
  • hSod1
  • HEL-S-44
  • homodimer
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
chemical
1
co-expressed gene
1
disease perturbation
1
kinase perturbation
1


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3333.1   (req: < 5)
Gene RIFs: 1064   (req: <= 3)
Antibodies: 1415   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3333.1   (req: >= 5)
Gene RIFs: 1064   (req: > 3)
Antibodies: 1415   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 67
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 8
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0