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Tbio
MT-CO3
Cytochrome c oxidase subunit 3

Protein Summary
Description
Subunits I, II and III form the functional core of the enzyme complex.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000362079
  • ENSP00000354982
  • ENSG00000198938

Symbol
  • COIII
  • COXIII
  • MTCO3
  • COIII
  • MTCO3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Related Tools
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ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 376.98   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 124   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 376.98   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 124   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitochondrially encoded cytochrome c oxidase III
VGNC:11716
807869
Macaque
cytochrome c oxidase subunit III
2846633
Mouse
MGI:102502
17710
Rat
RGD:621873
26204
Dog
cytochrome c oxidase subunit III
804480
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitochondrially encoded cytochrome c oxidase III
Macaque
cytochrome c oxidase subunit III
Mouse
Rat
Dog
cytochrome c oxidase subunit III
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P00414-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (24)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Metabolism
Reactome
Metabolism of RNA
Reactome
RNA Polymerase II Transcription
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
Metabolism
Metabolism of RNA
RNA Polymerase II Transcription
Protein-Protein Interactions (145)
1 – 10 of 145
LPAR1
Tchem
Family: GPCR
Novelty: 0.00318056
p_int: 0.908574347
p_ni: 0.091413338
p_wrong: 0.000012316
Score: 0.19
Data Source: BioPlex,STRINGDB
COX4I1
Tbio
Family: Enzyme
Novelty: 0.00208873
p_int: 0.841783762
p_ni: 0.158212984
p_wrong: 0.000003254
Score: 0.989
Data Source: BioPlex,STRINGDB
COX6A1
Tbio
Family: Enzyme
Novelty: 0.05543187
p_int: 0.823082754
p_ni: 0.176916413
p_wrong: 8.33e-7
Score: 0.985
Data Source: BioPlex,STRINGDB
MT-CO2
Tchem
Family: Enzyme
Novelty: 0.00073921
Score: 0.999
Data Source: STRINGDB
MT-CO1
Tchem
Family: Enzyme
Novelty: 0.00008262
Score: 0.999
Data Source: STRINGDB
MT-CYB
Tbio
Novelty: 0.00012093
Score: 0.999
Data Source: STRINGDB
MT-ATP6
Tbio
Family: Enzyme
Novelty: 0.00104191
Score: 0.999
Data Source: STRINGDB
MT-ND4
Tclin
Family: Enzyme
Novelty: 0.00079935
Score: 0.998
Data Source: STRINGDB
COX5A
Tbio
Family: Enzyme
Novelty: 0.02110193
Score: 0.997
Data Source: STRINGDB
MT-ND1
Tclin
Family: Enzyme
Novelty: 0.00090183
Score: 0.996
Data Source: STRINGDB
Publication Statistics
PubMed Score  376.98

PubMed score by year
PubTator Score  663.57

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer