Tchem MT-CO2 Cytochrome c oxidase subunit 2

Protein Summary

Description

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Uniprot Accession IDs

• P00403
• Q37526

Gene Name

• MT-CO2

Ensembl ID

• ENST00000361739
• ENSP00000354876
• ENSG00000198712

Symbol

• COII
• COX2
• COXII
• MTCO2
• COII
• MTCO2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0
biological term	0
cell line	0
cell type or tissue	0
cellular component	0

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Cytochrome C Oxidase Subunit 2

DTO Classes

Protein / Enzyme / Oxidoreductase / Cytochrome C Oxidase Subunit 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1589.14   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 198   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1589.14   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 198   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 5

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3