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Tchem
MT-CO2
Cytochrome c oxidase subunit 2

Protein Classes
Protein Summary
Description
Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361739
  • ENSP00000354876
  • ENSG00000198712

Symbol
  • COII
  • COX2
  • COXII
  • MTCO2
  • COII
  • MTCO2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Related Tools
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1369.23   (req: < 5)
Gene RIFs: 32   (req: <= 3)
Antibodies: 198   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1369.23   (req: >= 5)
Gene RIFs: 32   (req: > 3)
Antibodies: 198   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitochondrially encoded cytochrome c oxidase II
VGNC:11715
807864
Macaque
cytochrome c oxidase subunit II
2846628
Mouse
MGI:102503
17709
Rat
RGD:621872
26198
Dog
mitochondrially encoded cytochrome c oxidase II
VGNC:53137
804479
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitochondrially encoded cytochrome c oxidase II
Macaque
cytochrome c oxidase subunit II
Mouse
Rat
Dog
mitochondrially encoded cytochrome c oxidase II
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P00403-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (158)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Metabolism
Reactome
Metabolism of RNA
Reactome
RNA Polymerase II Transcription
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
Metabolism
Metabolism of RNA
RNA Polymerase II Transcription
Gene Ontology Terms (15)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (187)
1 – 10 of 187
COX4I1
Tbio
Family:  Enzyme
Novelty:  0.00208873
p_int:  0.752310372
p_ni:  0.247689628
Score:  0.999
Data Source:  BioPlex,STRINGDB
COX5A
Tbio
Family:  Enzyme
Novelty:  0.02110193
Score:  0.999
Data Source:  STRINGDB
MT-CO3
Tbio
Family:  Enzyme
Novelty:  0.00253369
Score:  0.999
Data Source:  STRINGDB
COX5B
Tbio
Family:  Enzyme
Novelty:  0.01729026
Score:  0.999
Data Source:  STRINGDB
COX6B1
Tbio
Family:  Enzyme
Novelty:  0.02531055
Score:  0.999
Data Source:  STRINGDB
COX7C
Tbio
Family:  Enzyme
Novelty:  0.05516787
Score:  0.999
Data Source:  STRINGDB
MT-CO1
Tchem
Family:  Enzyme
Novelty:  0.00008262
Score:  0.999
Data Source:  STRINGDB
COX6C
Tbio
Family:  Enzyme
Novelty:  0.04365165
Score:  0.999
Data Source:  STRINGDB
MT-CYB
Tbio
Novelty:  0.00012093
Score:  0.999
Data Source:  STRINGDB
COX7A2
Tbio
Family:  Enzyme
Novelty:  0.04287864
Score:  0.998
Data Source:  STRINGDB
Publication Statistics
PubMed Score  1369.23

PubMed score by year
PubTator Score  8346.71

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer