GSR
Glutathione reductase, mitochondrial
Protein Classes
Protein Summary
Maintains high levels of reduced glutathione in the cytosol. This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. This enzyme is a homodimeric flavoprotein. It is a central enzyme of cellular antioxidant defense, and reduces oxidized glutathione disulfide (GSSG) to the sulfhydryl form GSH, which is an important cellular antioxidant. Rare mutations in this gene result in hereditary glutathione reductase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Aug 2010]
- ENST00000221130
- ENSP00000221130
- ENSG00000104687
- ENST00000537535
- ENSP00000438845
- ENST00000541648
- ENSP00000444559
- ENST00000546342
- ENSP00000445516
- GLUR
- GRD1
- GR
- HEL-75
- HEL-S-122m
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
chemical | 1 | ||
transcription factor perturbation | 0.99 | ||
kinase perturbation | 0.96 | ||
molecular function | 0.94 | ||
protein domain | 0.92 | ||
Related Tools
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1749.07 (req: < 5)
Gene RIFs: 31 (req: <= 3)
Antibodies: 379 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1749.07 (req: >= 5)
Gene RIFs: 31 (req: > 3)
Antibodies: 379 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 7
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
Active Ligands (7)
1 – 7 of 7
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | glutathione-disulfide reductase | VGNC:14568 | 464099 | |||||
Mouse | MGI:95804 | 14782 | ||||||
Rat | RGD:621747 | 116686 | ||||||
Dog | glutathione-disulfide reductase | 475596 | ||||||
Horse | glutathione-disulfide reductase [Source:HGNC Symbol;Acc:HGNC:4623] | |||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | glutathione-disulfide reductase | |||||
Mouse | ||||||
Rat | ||||||
Dog | glutathione-disulfide reductase | |||||
Horse | glutathione-disulfide reductase [Source:HGNC Symbol;Acc:HGNC:4623] | |||||
Protein Structure (27 Structures, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 5 of 27
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (34)
Reactome (14)
KEGG (3)
PathwayCommons (2)
WikiPathways (15)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 14
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cellular responses to external stimuli | ||||
Reactome | Cellular responses to stress | ||||
Reactome | Detoxification of Reactive Oxygen Species | ||||
Reactome | Gene expression (Transcription) | ||||
Reactome | Generic Transcription Pathway | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cellular responses to external stimuli | ||||
Cellular responses to stress | ||||
Detoxification of Reactive Oxygen Species | ||||
Gene expression (Transcription) | ||||
Generic Transcription Pathway | ||||
Gene Ontology Terms (13)
Functions (4)
Components (5)
Processes (4)
Items per page:
10
1 – 4 of 4
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Protein-Protein Interactions (269)
1 – 10 of 269
GPX1
Family: Enzyme
Novelty: 0.000826
Score: 0.987
Data Source: STRINGDB
CAT
Family: Enzyme
Novelty: 0.00181888
Score: 0.987
Data Source: STRINGDB
GPX2
Family: Enzyme
Novelty: 0.00479104
Score: 0.986
Data Source: STRINGDB
GPX4
Family: Enzyme
Novelty: 0.00188213
Score: 0.985
Data Source: STRINGDB
GPX3
Family: Enzyme
Novelty: 0.0015734
Score: 0.985
Data Source: STRINGDB
GSS
Family: Enzyme
Novelty: 0.03002278
Score: 0.985
Data Source: STRINGDB
TXN
Novelty: 0.00048949
Score: 0.984
Data Source: STRINGDB
GPX7
Family: Enzyme
Novelty: 0.01342855
Score: 0.983
Data Source: STRINGDB
HPGDS
Family: Enzyme
Novelty: 0.00019629
Score: 0.972
Data Source: STRINGDB
G6PD
Family: Enzyme
Novelty: 0.00064455
Score: 0.964
Data Source: STRINGDB
Publication Statistics
PubMed Score 1749.07
PubMed score by year
PubTator Score 2351.32
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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