Tclin GSR Glutathione reductase, mitochondrial

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Reductase / Glutathione Reductase, Mitochondrial

Protein / Oxidoreductase / Oxidase / Glutathione Reductase, Mitochondrial

Protein / Oxidoreductase / Dehydrogenase / Glutathione Reductase, Mitochondrial

Protein Summary

Description

Maintains high levels of reduced glutathione in the cytosol. This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. This enzyme is a homodimeric flavoprotein. It is a central enzyme of cellular antioxidant defense, and reduces oxidized glutathione disulfide (GSSG) to the sulfhydryl form GSH, which is an important cellular antioxidant. Rare mutations in this gene result in hereditary glutathione reductase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Aug 2010]

Uniprot Accession IDs

• P00390
• C8KIL8
• C8KIL9
• C8KIM0
• D3DSV3
• Q7Z5C9
• Q9NP63
• GR

Gene Name

• GSR

Ensembl ID

• ENST00000221130
• ENSP00000221130
• ENSG00000104687
• ENST00000537535
• ENSP00000438845
• ENST00000541648
• ENSP00000444559
• ENST00000546342
• ENSP00000445516

Symbol

• GLUR
• GRD1
• GR
• HEL-75
• HEL-S-122m

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
chemical	1
transcription factor perturbation	0.99
kinase perturbation	0.96
molecular function	0.94
protein domain	0.92

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 919.04   (req: < 5)

Gene RIFs: 31   (req: <= 3)

Antibodies: 379   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 919.04   (req: >= 5)

Gene RIFs: 31   (req: > 3)

Antibodies: 379   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 7

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1

Approved Drugs (1)

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1 – 1 of 1

carmustine

GSRTclin Enzyme

INHIBITOR IC50: 5.09

Active Ligands (7)

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1 – 7 of 7

CHEMBL1824793

GSRTclin Enzyme

Ki: 6.68

CHEMBL135504

GSRTclin Enzyme

IC50: 6

CHEMBL39137

GSRTclin Enzyme

IC50: 6

CHEMBL287849

GSRTclin Enzyme

IC50: 6

CHEMBL39225

GSRTclin Enzyme

IC50: 6

CHEMBL135536

GSRTclin Enzyme

IC50: 6.12

CHEMBL120147

GSRTclin Enzyme

IC50: 8.39

Protein Data Bank (27)

1 – 5 of 27

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (34)

Reactome (14)

KEGG (3)

PathwayCommons (2)

WikiPathways (15)

Cellular responses to external stimuli (R-HSA-8953897)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cellular responses to external stimuli	487 targets	R-HSA-8953897
Reactome	Cellular responses to stress	392 targets	R-HSA-2262752
Reactome	Detoxification of Reactive Oxygen Species	37 targets	R-HSA-3299685
Reactome	Gene expression (Transcription)	1452 targets	R-HSA-74160
Reactome	Generic Transcription Pathway	1195 targets	R-HSA-212436

Name	Explore in Pharos	Explore in Source
Cellular responses to external stimuli	487 targets	R-HSA-8953897
Cellular responses to stress	392 targets	R-HSA-2262752
Detoxification of Reactive Oxygen Species	37 targets	R-HSA-3299685
Gene expression (Transcription)	1452 targets	R-HSA-74160
Generic Transcription Pathway	1195 targets	R-HSA-212436

Gene Ontology Terms (13)

Functions (4)

Components (5)

Processes (4)

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1 – 4 of 4

GO Term	Evidence	Assigned by
flavin adenine dinucleotide binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
glutathione-disulfide reductase activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
electron transfer activity	Traceable Author Statement (TAS)	UniProtKB
NADP binding	Inferred from Electronic Annotation (IEA)	InterPro

Protein-Protein Interactions (269)

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1 – 10 of 269

• See Interactions on String-DB

GPX1

Tbio

Family: Enzyme

Novelty: 0.00106459

Score: 0.987

Data Source: STRINGDB

CAT

Tbio

Family: Enzyme

Novelty: 0.00022628

Score: 0.987

Data Source: STRINGDB

GPX2

Tbio

Family: Enzyme

Novelty: 0.00492881

Score: 0.986

Data Source: STRINGDB

GPX4

Tbio

Family: Enzyme

Novelty: 0.00097753

Score: 0.985

Data Source: STRINGDB

GPX3

Tbio

Family: Enzyme

Novelty: 0.00199008

Score: 0.985

Data Source: STRINGDB

GSS

Tbio

Family: Enzyme

Novelty: 0.00180721

Score: 0.985

Data Source: STRINGDB

TXN

Tchem

Novelty: 0.00056085

Score: 0.984

Data Source: STRINGDB

GPX7

Tbio

Family: Enzyme

Novelty: 0.02063033

Score: 0.983

Data Source: STRINGDB

HPGDS

Tchem

Family: Enzyme

Novelty: 0.00017173

Score: 0.972

Data Source: STRINGDB

G6PD

Tchem

Family: Enzyme

Novelty: 0.00088391

Score: 0.964

Data Source: STRINGDB

Publication Statistics

PubMed Score  919.04

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PubTator Score  2351.32

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Amino Acid Sequence

Residue Counts

Protein Sequence

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3D-structure
Acetylation
Alternative initiation
Alternative splicing
Complete proteome
Cytoplasm
Direct protein sequencing
Disulfide bond
FAD
Flavoprotein

MGI Phenotype Find Similar Targets

cardiovascular system phenotype
vision/eye phenotype