GSR
Glutathione reductase, mitochondrial
Protein Summary
Maintains high levels of reduced glutathione in the cytosol. This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. This enzyme is a homodimeric flavoprotein. It is a central enzyme of cellular antioxidant defense, and reduces oxidized glutathione disulfide (GSSG) to the sulfhydryl form GSH, which is an important cellular antioxidant. Rare mutations in this gene result in hereditary glutathione reductase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Aug 2010]
- ENST00000221130
- ENSP00000221130
- ENSG00000104687
- ENST00000537535
- ENSP00000438845
- ENST00000541648
- ENSP00000444559
- ENST00000546342
- ENSP00000445516
- GLUR
- GRD1
- GR
- HEL-75
- HEL-S-122m
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
chemical | 1 | ||
transcription factor perturbation | 0.99 | ||
kinase perturbation | 0.96 | ||
molecular function | 0.94 | ||
protein domain | 0.92 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1158.81 (req: < 5)
Gene RIFs: 35 (req: <= 3)
Antibodies: 379 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1158.81 (req: >= 5)
Gene RIFs: 35 (req: > 3)
Antibodies: 379 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 7
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1