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Tclin
GSR
Glutathione reductase, mitochondrial

Protein Summary
Description
Maintains high levels of reduced glutathione in the cytosol. This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. This enzyme is a homodimeric flavoprotein. It is a central enzyme of cellular antioxidant defense, and reduces oxidized glutathione disulfide (GSSG) to the sulfhydryl form GSH, which is an important cellular antioxidant. Rare mutations in this gene result in hereditary glutathione reductase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Aug 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000221130
  • ENSP00000221130
  • ENSG00000104687
  • ENST00000537535
  • ENSP00000438845
  • ENST00000541648
  • ENSP00000444559
  • ENST00000546342
  • ENSP00000445516

Symbol
  • GLUR
  • GRD1
  • GR
  • HEL-75
  • HEL-S-122m
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
1
transcription factor perturbation
0.99
kinase perturbation
0.96
molecular function
0.94
protein domain
0.92


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1749.07   (req: < 5)
Gene RIFs: 31   (req: <= 3)
Antibodies: 379   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1749.07   (req: >= 5)
Gene RIFs: 31   (req: > 3)
Antibodies: 379   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 7
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
carmustine
chemical structure image
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glutathione-disulfide reductase
VGNC:14568
464099
Mouse
MGI:95804
14782
Rat
RGD:621747
116686
Dog
glutathione-disulfide reductase
475596
Horse
glutathione-disulfide reductase [Source:HGNC Symbol;Acc:HGNC:4623]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glutathione-disulfide reductase
Mouse
Rat
Dog
glutathione-disulfide reductase
Horse
glutathione-disulfide reductase [Source:HGNC Symbol;Acc:HGNC:4623]
Protein Structure (27 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P00390-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 27
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (34)
Cellular responses to external stimuli (R-HSA-8953897)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Detoxification of Reactive Oxygen Species
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Name
Explore in Pharos
Explore in Source
Cellular responses to external stimuli
Cellular responses to stress
Detoxification of Reactive Oxygen Species
Gene expression (Transcription)
Generic Transcription Pathway
Protein-Protein Interactions (269)
1 – 10 of 269
GPX1
Tbio
Family: Enzyme
Novelty: 0.000826
Score: 0.987
Data Source: STRINGDB
CAT
Tbio
Family: Enzyme
Novelty: 0.00181888
Score: 0.987
Data Source: STRINGDB
GPX2
Tbio
Family: Enzyme
Novelty: 0.00479104
Score: 0.986
Data Source: STRINGDB
GPX4
Tbio
Family: Enzyme
Novelty: 0.00188213
Score: 0.985
Data Source: STRINGDB
GPX3
Tbio
Family: Enzyme
Novelty: 0.0015734
Score: 0.985
Data Source: STRINGDB
GSS
Tbio
Family: Enzyme
Novelty: 0.03002278
Score: 0.985
Data Source: STRINGDB
TXN
Tchem
Novelty: 0.00048949
Score: 0.984
Data Source: STRINGDB
GPX7
Tbio
Family: Enzyme
Novelty: 0.01342855
Score: 0.983
Data Source: STRINGDB
HPGDS
Tchem
Family: Enzyme
Novelty: 0.00019629
Score: 0.972
Data Source: STRINGDB
G6PD
Tchem
Family: Enzyme
Novelty: 0.00064455
Score: 0.964
Data Source: STRINGDB
Publication Statistics
PubMed Score  1749.07

PubMed score by year
PubTator Score  2351.32

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer