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Tchem
ALDH1A1
Retinal dehydrogenase 1

Protein Summary
Description
Can convert/oxidize retinaldehyde to retinoic acid. Binds free retinal and cellular retinol-binding protein-bound retinal (By similarity). May have a broader specificity and oxidize other aldehydes in vivo (PubMed:19296407, PubMed:26373694, PubMed:25450233). The protein encoded by this gene belongs to the aldehyde dehydrogenase family. Aldehyde dehydrogenase is the next enzyme after alcohol dehydrogenase in the major pathway of alcohol metabolism. There are two major aldehyde dehydrogenase isozymes in the liver, cytosolic and mitochondrial, which are encoded by distinct genes, and can be distinguished by their electrophoretic mobility, kinetic properties, and subcellular localization. This gene encodes the cytosolic isozyme. Studies in mice show that through its role in retinol metabolism, this gene may also be involved in the regulation of the metabolic responses to high-fat diet. [provided by RefSeq, Mar 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000297785
  • ENSP00000297785
  • ENSG00000165092

Symbol
  • ALDC
  • ALDH1
  • PUMB1
  • ALDC
  • ALDH1
  • HEL-9
  • HEL12
  • PUMB1
  • ALDH11
  • RALDH1
  • ALDH-E1
  • HEL-S-53e
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.97
transcription factor perturbation
0.94
gene perturbation
0.92
biological term
0.91
protein domain
0.85


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 895.56   (req: < 5)
Gene RIFs: 262   (req: <= 3)
Antibodies: 956   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 895.56   (req: >= 5)
Gene RIFs: 262   (req: > 3)
Antibodies: 956   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 21
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (21)
1 – 10 of 21
CHEMBL3128208
chemical structure image
CHEMBL3102994
chemical structure image
CHEMBL3128203
chemical structure image
CHEMBL3128206
chemical structure image
CHEMBL3128205
chemical structure image
CHEMBL1453099
chemical structure image
CHEMBL1328547
chemical structure image
CHEMBL3128209
chemical structure image
CHEMBL1527610
chemical structure image
CHEMBL3416555
chemical structure image
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
aldehyde dehydrogenase 1 family member A1
VGNC:4608
464529
Macaque
aldehyde dehydrogenase 1 family member A1
702598
Mouse
MGI:1353450
11668
Rat
RGD:2087
24188
Dog
aldehyde dehydrogenase 1 family member A1
VGNC:37782
476323
Species
Name
OMA
EggNOG
Inparanoid
Chimp
aldehyde dehydrogenase 1 family member A1
Macaque
aldehyde dehydrogenase 1 family member A1
Mouse
Rat
Dog
aldehyde dehydrogenase 1 family member A1
Protein Structure (10 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P00352-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 10
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (29)
Biological oxidations (R-HSA-211859)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Ethanol oxidation
Reactome
Fructose catabolism
Reactome
Fructose metabolism
Reactome
Metabolism
Name
Explore in Pharos
Explore in Source
Biological oxidations
Ethanol oxidation
Fructose catabolism
Fructose metabolism
Metabolism
Gene Ontology Terms (16)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
CAFA
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
UniProtKB
Protein-Protein Interactions (169)
1 – 10 of 169
IL21
Tbio
Novelty: 0.00396187
p_int: 0.846032248
p_ni: 0.128541769
p_wrong: 0.025425983
Score: 0.692
Data Source: BioPlex,STRINGDB
CYP26A1
Tchem
Family: Enzyme
Novelty: 0.00281805
Score: 0.967
Data Source: STRINGDB
CYP26B1
Tchem
Novelty: 0.00990332
Score: 0.958
Data Source: STRINGDB
CYP26C1
Tbio
Novelty: 0.04960237
Score: 0.953
Data Source: STRINGDB
RDH11
Tbio
Family: Enzyme
Novelty: 0.02758936
Score: 0.95
Data Source: STRINGDB
DHRS9
Tbio
Family: Enzyme
Novelty: 0.00256743
Score: 0.947
Data Source: STRINGDB
RDH12
Tbio
Family: Enzyme
Novelty: 0.016003
Score: 0.945
Data Source: STRINGDB
RDH5
Tbio
Family: Enzyme
Novelty: 0.0111079
Score: 0.943
Data Source: STRINGDB
DHRS3
Tbio
Family: Enzyme
Novelty: 0.04448013
Score: 0.938
Data Source: STRINGDB
BCO1
Tbio
Family: Enzyme
Novelty: 0.00784197
Score: 0.934
Data Source: STRINGDB
Publication Statistics
PubMed Score  895.56

PubMed score by year
PubTator Score  602.36

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer