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Tchem
LDHA
L-lactate dehydrogenase A chain

Protein Summary
Description
The protein encoded by this gene catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. The protein is found predominantly in muscle tissue and belongs to the lactate dehydrogenase family. Mutations in this gene have been linked to exertional myoglobinuria. Multiple transcript variants encoding different isoforms have been found for this gene. The human genome contains several non-transcribed pseudogenes of this gene. [provided by RefSeq, Sep 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000227157
  • ENSP00000227157
  • ENSG00000134333
  • ENST00000379412
  • ENSP00000368722
  • ENST00000396222
  • ENSP00000379524
  • ENST00000422447
  • ENSP00000395337
  • ENST00000430553
  • ENSP00000406172
  • ENST00000540430
  • ENSP00000445175
  • ENST00000542179
  • ENSP00000445331

Symbol
  • LDHM
  • GSD11
  • PIG19
  • HEL-S-133P
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
interacting protein
1
protein complex
1
virus perturbation
0.98
kinase perturbation
0.97


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1426.15   (req: < 5)
Gene RIFs: 123   (req: <= 3)
Antibodies: 810   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1426.15   (req: >= 5)
Gene RIFs: 123   (req: > 3)
Antibodies: 810   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 80
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum amyloid A protein measurement
1
1
1
82.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum amyloid A protein measurement
1
82.8
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
lactate dehydrogenase A
VGNC:1085
451063
Macaque
lactate dehydrogenase A
694309
Mouse
MGI:96759
16828
Rat
RGD:2996
24533
Dog
lactate dehydrogenase A
476882
Species
Name
OMA
EggNOG
Inparanoid
Chimp
lactate dehydrogenase A
Macaque
lactate dehydrogenase A
Mouse
Rat
Dog
lactate dehydrogenase A
Protein Structure (31 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P00338-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 31
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (31)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Pyruvate metabolism
Reactome
Pyruvate metabolism and Citric Acid (TCA) cycle
Reactome
The citric acid (TCA) cycle and respiratory electron transport
Name
Explore in Pharos
Explore in Source
Metabolism
Pyruvate metabolism
Pyruvate metabolism and Citric Acid (TCA) cycle
The citric acid (TCA) cycle and respiratory electron transport
Gene Ontology Terms (22)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (291)
1 – 10 of 291
LDHC
Tbio
Family: Enzyme
Novelty: 0.00213484
p_int: 0.999999996
p_ni: 4e-9
Score: 0.914
Data Source: BioPlex,STRINGDB
LDHB
Tchem
Family: Enzyme
Novelty: 0.00242213
p_int: 0.999166363
p_ni: 0.000833637
Score: 0.994
Data Source: BioPlex,Reactome,STRINGDB
HIF1A
Tchem
Family: TF
Novelty: 0.00011503
Score: 0.979
Data Source: STRINGDB
PKM
Tchem
Family: Kinase
Novelty: 0.00076567
Score: 0.977
Data Source: STRINGDB
ME2
Tbio
Novelty: 0.03635548
Score: 0.971
Data Source: STRINGDB
LDHD
Tbio
Family: Enzyme
Novelty: 0.0230704
Score: 0.969
Data Source: STRINGDB
PC
Tbio
Family: Enzyme
Novelty: 0.00271694
Score: 0.965
Data Source: STRINGDB
ARNT
Tbio
Family: TF
Novelty: 0.00183071
Score: 0.959
Data Source: STRINGDB
GPI
Tbio
Family: Enzyme
Novelty: 0.00095404
Score: 0.945
Data Source: STRINGDB
EP300
Tchem
Family: Epigenetic
Novelty: 0.00055009
Score: 0.945
Data Source: STRINGDB
Publication Statistics
PubMed Score  1426.15

PubMed score by year
PubTator Score  377.05

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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