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Tchem
LDHA
L-lactate dehydrogenase A chain

Protein Summary
Description
The protein encoded by this gene catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. The protein is found predominantly in muscle tissue and belongs to the lactate dehydrogenase family. Mutations in this gene have been linked to exertional myoglobinuria. Multiple transcript variants encoding different isoforms have been found for this gene. The human genome contains several non-transcribed pseudogenes of this gene. [provided by RefSeq, Sep 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000227157
  • ENSP00000227157
  • ENSG00000134333
  • ENST00000379412
  • ENSP00000368722
  • ENST00000396222
  • ENSP00000379524
  • ENST00000422447
  • ENSP00000395337
  • ENST00000430553
  • ENSP00000406172
  • ENST00000540430
  • ENSP00000445175
  • ENST00000542179
  • ENSP00000445331

Symbol
  • LDHM
  • GSD11
  • PIG19
  • HEL-S-133P
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
interacting protein
1
protein complex
1
virus perturbation
0.98
kinase perturbation
0.97


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1708.24   (req: < 5)
Gene RIFs: 123   (req: <= 3)
Antibodies: 810   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1708.24   (req: >= 5)
Gene RIFs: 123   (req: > 3)
Antibodies: 810   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 287
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0