Protein Summary
Cytochrome b5 is a membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases. The protein encoded by this gene is a membrane-bound cytochrome that reduces ferric hemoglobin (methemoglobin) to ferrous hemoglobin, which is required for stearyl-CoA-desaturase activity. Defects in this gene are a cause of type IV hereditary methemoglobinemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
- ENST00000340533
- ENSP00000341625
- ENSG00000166347
- ENST00000397914
- ENSP00000381011
- ENST00000494131
- ENSP00000436461
- CYB5
- CYB5
- MCB5
- METAG
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.93 | ||
transcription factor perturbation | 0.91 | ||
cellular component | 0.9 | ||
kinase perturbation | 0.88 | ||
disease perturbation | 0.83 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2002.43 (req: < 5)
Gene RIFs: 36 (req: <= 3)
Antibodies: 338 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2002.43 (req: >= 5)
Gene RIFs: 36 (req: > 3)
Antibodies: 338 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0