Protein Summary
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
- ENST00000361789
- ENSP00000354554
- ENSG00000198727
- COB
- CYTB
- MTCYB
- MTCYB
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
microRNA | 0.95 | ||
cellular component | 0.9 | ||
small molecule perturbation | 0.81 | ||
molecular function | 0.7 | ||
protein domain | 0.58 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 8645.12 (req: < 5)
Gene RIFs: 20 (req: <= 3)
Antibodies: 163 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 8645.12 (req: >= 5)
Gene RIFs: 20 (req: > 3)
Antibodies: 163 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 17
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (259)
UQCRB
Novelty: 0.02933046
p_int: 0.999977286
p_ni: 0.000022714
Score: 0.999
Data Source: BioPlex,STRINGDB
UQCRQ
Novelty: 0.04392627
p_int: 0.999972982
p_ni: 0.000026836
p_wrong: 1.82e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
PTGES2
Family: Enzyme
Novelty: 0.01415352
p_int: 0.999900327
p_ni: 0.000030095
p_wrong: 0.000069578
Data Source: BioPlex
UQCRH
Novelty: 0.04494433
p_int: 0.995231092
p_ni: 0.000298684
p_wrong: 0.004470224
Score: 0.999
Data Source: BioPlex,STRINGDB
MRPL50
Novelty: 0.88879319
p_int: 0.994702294
p_ni: 0.000506882
p_wrong: 0.004790823
Data Source: BioPlex
CLDND1
Novelty: 0.06681793
p_int: 0.994435508
p_ni: 0.00021298
p_wrong: 0.005351513
Score: 0.189
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (19)
Reactome (9)
KEGG (8)
WikiPathways (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Metabolism | ||||
Reactome | Metabolism of RNA | ||||
Reactome | Respiratory electron transport | ||||
Reactome | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | ||||
Reactome | The citric acid (TCA) cycle and respiratory electron transport | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Metabolism | ||||
Metabolism of RNA | ||||
Respiratory electron transport | ||||
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | ||||
The citric acid (TCA) cycle and respiratory electron transport | ||||
Viral Interactions (0)
Gene Ontology Terms (21)
Functions (3)
Components (4)
Processes (14)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Non-traceable Author Statement (NAS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (0)
Find similar targets by:
IDG Resources
Orthologs (15)
1 – 5 of 15
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | mitochondrially encoded cytochrome b | VGNC:11718 | 807858 | |||||
Macaque | cytochrome b | 2846625 | ||||||
Mouse | MGI:102501 | 17711 | ||||||
Rat | RGD:620081 | 26192 | ||||||
Dog | mitochondrially encoded cytochrome b | VGNC:53138 | 804486 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | mitochondrially encoded cytochrome b | |||||
Macaque | cytochrome b | |||||
Mouse | ||||||
Rat | ||||||
Dog | mitochondrially encoded cytochrome b | |||||
Publication Statistics
PubMed Score 8645.12
PubMed score by year
PubTator Score 2575.87
PubTator score by year
Related Publications
Text Mined References (1)
GeneRif Annotations (20)
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