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Tbio
OXA1L
Mitochondrial inner membrane protein OXA1L

Protein Summary
Description
Required for the insertion of integral membrane proteins into the mitochondrial inner membrane. Essential for the activity and assembly of cytochrome oxidase. Required for the correct biogenesis of ATP synthase and complex I in mitochondria. This gene encodes an evolutionarily conserved protein that is localized to the inner mitochondrial membrane. The encoded protein is essential for the translocation of the N-terminal tail of subunit 2 of cytochrome c oxidase, and is involved in the assembly of the cytochrome c oxidase and ATPase complexes of the mitochondrial respiratory chain. [provided by RefSeq, Jul 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358043
  • ENSP00000350740
  • ENSG00000155463

Symbol
  • OXA1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.96
kinase perturbation
0.91
transcription factor perturbation
0.88
histone modification site profile
0.75
transcription factor binding site profile
0.74


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1095.13   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 180   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1095.13   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 180   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (246)
MRPL18
Tbio
Novelty:  0.73438796
p_int:  0.887687597
p_ni:  0.112312403
Score:  0.903
Data Source:  BioPlex,STRINGDB
GFM1
Tbio
Novelty:  0.00503994
Score:  0.986
Data Source:  STRINGDB
TUFM
Tchem
Novelty:  0.03251632
Score:  0.985
Data Source:  STRINGDB
MRPL4
Tbio
Novelty:  0.27290276
Score:  0.984
Data Source:  STRINGDB
MRPL51
Tdark
Novelty:  0.24304433
Score:  0.979
Data Source:  STRINGDB
MRPL49
Tbio
Novelty:  0.03727552
Score:  0.977
Data Source:  STRINGDB
MRPL3
Tbio
Novelty:  0.11814129
Score:  0.976
Data Source:  STRINGDB
MRPL48
Tdark
Novelty:  0.31837402
Score:  0.971
Data Source:  STRINGDB
MRPL20
Tdark
Novelty:  0.91178993
Score:  0.969
Data Source:  STRINGDB
MRPS5
Tbio
Novelty:  0.11423336
Score:  0.969
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Mitochondrial translation
Reactome
Mitochondrial translation elongation
Reactome
Mitochondrial translation initiation
Reactome
Mitochondrial translation termination
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Mitochondrial translation
Mitochondrial translation elongation
Mitochondrial translation initiation
Mitochondrial translation termination
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
1
3
88.5
Dupuytren Contracture
1
1
0
1.3
86.8
intraocular pressure measurement
1
1
0
8.4
83.6
diastolic blood pressure
2
1
2
69.5
type 2 diabetes mellitus
1
1
0
1
33.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
88.5
Dupuytren Contracture
0
1.3
86.8
intraocular pressure measurement
0
8.4
83.6
diastolic blood pressure
2
69.5
type 2 diabetes mellitus
0
1
33.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
OXA1L, mitochondrial inner membrane protein
VGNC:10311
452785
Macaque
OXA1L, mitochondrial inner membrane protein
712222
Mouse
MGI:1916339
69089
Rat
RGD:1585024
691393
Dog
OXA1L, mitochondrial inner membrane protein
VGNC:44199
480239
Species
Name
OMA
EggNOG
Inparanoid
Chimp
OXA1L, mitochondrial inner membrane protein
Macaque
OXA1L, mitochondrial inner membrane protein
Mouse
Rat
Dog
OXA1L, mitochondrial inner membrane protein
Publication Statistics
PubMed Score 1095.13
PubMed score by year
PubTator Score 318.19
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title