You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
OTUD6A
OTU domain-containing protein 6A

Protein Summary
Description
Deubiquitinating enzyme that hydrolyzes 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains. Also able to hydrolyze 'Lys-11'-linked ubiquitin chains. Deubiquitinating enzymes (DUBs; see MIM 603478) are proteases that specifically cleave ubiquitin (MIM 191339) linkages, negating the action of ubiquitin ligases. DUBA2 belongs to a DUB subfamily characterized by an ovarian tumor (OTU) domain.[supplied by OMIM, May 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000338352
  • ENSP00000339389
  • ENSG00000189401

Symbol
  • DUBA2
  • DUBA2
  • HSHIN6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue
0.59
cell type or tissue
0.44
cell line
0.4
tissue sample
0.4
microRNA
0.32


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.46   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 111   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.46   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 111   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (58)
GPR21
Tdark
Family:  GPCR
Novelty:  0.90865557
p_int:  0.999986422
p_wrong:  0.000013578
Score:  0.188
Data Source:  BioPlex,STRINGDB
YOD1
Tbio
Family:  Enzyme
Novelty:  0.05709057
Score:  0.812
Data Source:  STRINGDB
OTUD1
Tbio
Novelty:  0.12046014
Score:  0.714
Data Source:  STRINGDB
USP27X
Tbio
Family:  Enzyme
Novelty:  0.12550111
Score:  0.665
Data Source:  STRINGDB
USP43
Tdark
Family:  Enzyme
Novelty:  0.35631094
Score:  0.631
Data Source:  STRINGDB
OTUB2
Tbio
Family:  Enzyme
Novelty:  0.00821431
Score:  0.627
Data Source:  STRINGDB
OTUD7A
Tbio
Novelty:  0.09531354
Score:  0.617
Data Source:  STRINGDB
OTUD7B
Tbio
Novelty:  0.0136028
Score:  0.616
Data Source:  STRINGDB
OTUD4
Tbio
Novelty:  0.17121119
Score:  0.614
Data Source:  STRINGDB
USP5
Tchem
Family:  Enzyme
Novelty:  0.01478795
Score:  0.609
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:3644685
408193
Rat
RGD:1560855
302426
Dog
OTU deubiquitinase 6A
VGNC:44188
491937
Horse
OTU domain-containing protein 6A-like
100056237
Cow
OTU deubiquitinase 6A
VGNC:32497
532172
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
OTU deubiquitinase 6A
Horse
OTU domain-containing protein 6A-like
Cow
OTU deubiquitinase 6A
Publication Statistics
PubMed Score 1.46
PubMed score by year
PubTator Score 0.33
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title