Tbio OTUD6A OTU domain-containing protein 6A

Protein Summary

Description

Deubiquitinating enzyme that hydrolyzes 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains. Also able to hydrolyze 'Lys-11'-linked ubiquitin chains. Deubiquitinating enzymes (DUBs; see MIM 603478) are proteases that specifically cleave ubiquitin (MIM 191339) linkages, negating the action of ubiquitin ligases. DUBA2 belongs to a DUB subfamily characterized by an ovarian tumor (OTU) domain.[supplied by OMIM, May 2008]

Uniprot Accession IDs

• Q7L8S5
• B2RPB7

Gene Name

• OTUD6A

Ensembl ID

• ENST00000338352
• ENSP00000339389
• ENSG00000189401

Symbol

• DUBA2
• DUBA2
• HSHIN6

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue	0.59
cell type or tissue	0.44
cell line	0.4
tissue sample	0.4
microRNA	0.32

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Otu Domain-containing Protein 6a

Protein / Hydrolase / Protease / Cysteine Protease / Otu Domain-containing Protein 6a

DTO Classes

Protein / Enzyme / Protease / Cysteine Protease / Otu Domain-containing Protein 6a

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.46   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 111   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.46   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 111   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

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ProtVista Viewer

Related Tools (3)

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (58)

Explore Interacting Targets

1 – 10 of 58

• See Interactions on String-DB

GPR21

Tdark

Family:  GPCR

Novelty:  0.90865557

p_int:  0.999986422

p_wrong:  0.000013578

Score:  0.188

Data Source:  BioPlex,STRINGDB

YOD1

Tbio

Family:  Enzyme

Novelty:  0.05709057

Score:  0.812

Data Source:  STRINGDB

OTUD1

Tbio

Novelty:  0.12046014

Score:  0.714

Data Source:  STRINGDB

USP27X

Tbio

Family:  Enzyme

Novelty:  0.12550111

Score:  0.665

Data Source:  STRINGDB

USP43

Tdark

Family:  Enzyme

Novelty:  0.35631094

Score:  0.631

Data Source:  STRINGDB

OTUB2

Tbio

Family:  Enzyme

Novelty:  0.00821431

Score:  0.627

Data Source:  STRINGDB

OTUD7A

Tbio

Novelty:  0.09531354

Score:  0.617

Data Source:  STRINGDB

OTUD7B

Tbio

Novelty:  0.0136028

Score:  0.616

Data Source:  STRINGDB

OTUD4

Tbio

Novelty:  0.17121119

Score:  0.614

Data Source:  STRINGDB

USP5

Tchem

Family:  Enzyme

Novelty:  0.01478795

Score:  0.609

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (5)

Functions (1)

Processes (4)

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GO Term	Evidence	Assigned by
thiol-dependent ubiquitin-specific protease activity	Inferred from Direct Assay (IDA)	UniProtKB

Disease Associations (null)

No disease associations found

GWAS Traits (0)

No GWAS traits found

Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Complete proteome
Hydrolase
Protease
Reference proteome
Thiol protease
Ubl conjugation pathway

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype

IDG Resources

No IDG generated resources found

Orthologs (8)

1 – 5 of 8

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Mouse	OTU domain containing 6A	MGI:3644685	408193
Rat	OTU deubiquitinase 6A	RGD:1560855	302426
Dog	OTU deubiquitinase 6A	VGNC:44188	491937
Horse	OTU domain-containing protein 6A-like		100056237
Cow	OTU deubiquitinase 6A	VGNC:32497	532172

Species	Name	OMA	EggNOG	Inparanoid
Mouse	OTU domain containing 6A
Rat	OTU deubiquitinase 6A
Dog	OTU deubiquitinase 6A
Horse	OTU domain-containing protein 6A-like
Cow	OTU deubiquitinase 6A

Publication Statistics

PubMed Score 1.46

PubMed score by year

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PubTator Score 0.33

PubTator score by year

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Related Publications

Text Mined References (4)

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10

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PMID	Year	Title