Tbio OTUD6A OTU domain-containing protein 6A

Protein Summary

Description

Deubiquitinating enzyme that hydrolyzes 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains. Also able to hydrolyze 'Lys-11'-linked ubiquitin chains. Deubiquitinating enzymes (DUBs; see MIM 603478) are proteases that specifically cleave ubiquitin (MIM 191339) linkages, negating the action of ubiquitin ligases. DUBA2 belongs to a DUB subfamily characterized by an ovarian tumor (OTU) domain.[supplied by OMIM, May 2008]

Uniprot Accession IDs

• Q7L8S5
• B2RPB7

Gene Name

• OTUD6A

Ensembl ID

• ENST00000338352
• ENSP00000339389
• ENSG00000189401

Symbol

• DUBA2
• DUBA2
• HSHIN6

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue	0.59
cell type or tissue	0.44
cell line	0.4
tissue sample	0.4
microRNA	0.32

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Otu Domain-containing Protein 6a

Protein / Hydrolase / Protease / Cysteine Protease / Otu Domain-containing Protein 6a

DTO Classes

Protein / Enzyme / Protease / Cysteine Protease / Otu Domain-containing Protein 6a

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.95   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 111   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.95   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 111   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0