Protein Summary
Collagen-like protein specifically expressed in the inner ear, which provides an organic scaffold for otoconia, a calcium carbonate structure in the saccule and utricle of the ear. Acts as a scaffold for biomineralization: sequesters calcium and forms interconnecting fibrils between otoconia that are incorporated into the calcium crystal structure. Together with OC90, modulates calcite crystal morphology and growth kinetics. This gene encodes a secreted glycoprotein with a C-terminal complement Cq1-like globular domain that belongs to the C1q/tumor necrosis factor-related protein (CTRP) family. The encoded protein is expressed in the inner ear and forms a multimeric complex called the otoconia, together with cerebellin-1 and otoconin-90, as part of the otoconial membrane. It contains extensive posttranslational modifications including hydroxylated prolines and glycosylated lysines. Naturally occurring mutations in this gene are associated with abnormal otoconia formation and balance de ...more
- ENST00000327928
- ENSP00000330808
- ENSG00000182447
- C1QTNF15
- C1QTNF16
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cell line | 0.69 | ||
tissue | 0.57 | ||
cell type or tissue | 0.49 | ||
protein domain | 0.41 | ||
protein complex | 0.4 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 22.83 (req: < 5)
Gene RIFs: 4 (req: <= 3)
Antibodies: 66 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 22.83 (req: >= 5)
Gene RIFs: 4 (req: > 3)
Antibodies: 66 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (15)
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (9)
Functions (2)
Components (4)
Processes (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Disease Associations (null)
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
self reported educational attainment | 1 | 1 | 1 | 57.3 | |||||
mathematical ability | 3 | 3 | 3 | 56.4 | |||||
Oral ulcer | 1 | 1 | 0 | 1.2 | 28 | ||||
amino acid measurement | 1 | 1 | 1 | 2.5 | |||||
alcohol consumption measurement | 1 | 1 | 1 | 1.4 | |||||
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
self reported educational attainment | 1 | 57.3 | |||||
mathematical ability | 3 | 56.4 | |||||
Oral ulcer | 0 | 1.2 | 28 | ||||
amino acid measurement | 1 | 2.5 | |||||
alcohol consumption measurement | 1 | 1.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | otolin 1 | 100426070 | ||||||
Mouse | MGI:2685260 | 229389 | ||||||
Rat | RGD:1562064 | 295117 | ||||||
Dog | otolin 1 | VGNC:44178 | 100855781 | |||||
Horse | otolin 1 | VGNC:21082 | 100062344 | |||||
Publication Statistics
PubMed Score 22.83
PubMed score by year
PubTator Score 6.80
PubTator score by year
Related Publications
Text Mined References (12)
GeneRif Annotations (4)
Items per page:
0 of 0
PMID | Year | Title |
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