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Tbio
OTOL1
Otolin-1

Protein Summary
Description
Collagen-like protein specifically expressed in the inner ear, which provides an organic scaffold for otoconia, a calcium carbonate structure in the saccule and utricle of the ear. Acts as a scaffold for biomineralization: sequesters calcium and forms interconnecting fibrils between otoconia that are incorporated into the calcium crystal structure. Together with OC90, modulates calcite crystal morphology and growth kinetics. This gene encodes a secreted glycoprotein with a C-terminal complement Cq1-like globular domain that belongs to the C1q/tumor necrosis factor-related protein (CTRP) family. The encoded protein is expressed in the inner ear and forms a multimeric complex called the otoconia, together with cerebellin-1 and otoconin-90, as part of the otoconial membrane. It contains extensive posttranslational modifications including hydroxylated prolines and glycosylated lysines. Naturally occurring mutations in this gene are associated with abnormal otoconia formation and balance de ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000327928
  • ENSP00000330808
  • ENSG00000182447

Symbol
  • C1QTNF15
  • C1QTNF16
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.69
tissue
0.57
cell type or tissue
0.49
protein domain
0.41
protein complex
0.4


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.83   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 66   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.83   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 66   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (15)
OC90
Tbio
Novelty:  0.06959011
Score:  0.808
Data Source:  STRINGDB
TECTB
Tbio
Novelty:  0.04489491
Score:  0.679
Data Source:  STRINGDB
OTOGL
Tbio
Novelty:  0.11538923
Score:  0.669
Data Source:  STRINGDB
OTOG
Tdark
Novelty:  0.04344519
Score:  0.639
Data Source:  STRINGDB
CBLN1
Tbio
Novelty:  0.01830505
Score:  0.55
Data Source:  STRINGDB
OTOF
Tbio
Novelty:  0.00676341
Score:  0.545
Data Source:  STRINGDB
POU4F3
Tbio
Family:  TF
Novelty:  0.01131683
Score:  0.483
Data Source:  STRINGDB
AHSG
Tbio
Novelty:  0.00112502
Score:  0.474
Data Source:  STRINGDB
SERPINI1
Tbio
Novelty:  0.00518205
Score:  0.474
Data Source:  STRINGDB
OTOP1
Tbio
Novelty:  0.04916753
Score:  0.469
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
1
1
57.3
mathematical ability
3
3
3
56.4
Oral ulcer
1
1
0
1.2
28
amino acid measurement
1
1
1
2.5
alcohol consumption measurement
1
1
1
1.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
57.3
mathematical ability
3
56.4
Oral ulcer
0
1.2
28
amino acid measurement
1
2.5
alcohol consumption measurement
1
1.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
otolin 1
100426070
Mouse
MGI:2685260
229389
Rat
RGD:1562064
295117
Dog
otolin 1
VGNC:44178
100855781
Horse
otolin 1
VGNC:21082
100062344
Species
Name
OMA
EggNOG
Inparanoid
Macaque
otolin 1
Mouse
Rat
Dog
otolin 1
Horse
otolin 1
Publication Statistics
PubMed Score 22.83
PubMed score by year
PubTator Score 6.80
PubTator score by year
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Related Publications
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PMID
Year
Title