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Tbio
OTOGL
Otogelin-like protein

Protein Summary
Description
The protein encoded by this gene belongs to the otogelin family. This gene is expressed in the inner ear of vertebrates with the highest level of expression seen at the embryonic stage and lowest in adult. Knockdown studies in zebrafish suggest that this gene is essential for normal inner ear function. Mutations in this gene are associated with autosomal recessive deafness. [provided by RefSeq, Dec 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000547103
  • ENSP00000447211
  • ENSG00000165899

Symbol
  • C12orf64
  • DFNB84B
  • C12orf64
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.54
tissue
0.53
tissue sample
0.51
disease
0.47
microRNA
0.46


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.04   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 14   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.04   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 14   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (39)
MYLK4
Tchem
Family:  Kinase
Novelty:  0.14967851
Score:  0.711
Data Source:  STRINGDB
OTOA
Tbio
Novelty:  0.04940755
Score:  0.684
Data Source:  STRINGDB
CEACAM16
Tbio
Novelty:  0.11153655
Score:  0.676
Data Source:  STRINGDB
OTOL1
Tbio
Novelty:  0.05900218
Score:  0.669
Data Source:  STRINGDB
MCUR1
Tbio
Novelty:  0.06505266
Score:  0.666
Data Source:  STRINGDB
TECTB
Tbio
Novelty:  0.04489491
Score:  0.656
Data Source:  STRINGDB
STRC
Tbio
Novelty:  0.01587212
Score:  0.625
Data Source:  STRINGDB
TMEM191C
Tdark
Novelty:  14.07662526
Score:  0.609
Data Source:  STRINGDB
TMEM236
Tdark
Novelty:  2.30662044
Score:  0.609
Data Source:  STRINGDB
TMEM191B
Tdark
Novelty:  14.07662526
Score:  0.609
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.6
3.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.6
3.3
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
otogelin like
VGNC:8482
452097
Mouse
MGI:3647600
628870
Rat
RGD:1589018
685868
Cow
otogelin like
VGNC:32486
531410
Pig
otogelin like
100513796
Species
Name
OMA
EggNOG
Inparanoid
Chimp
otogelin like
Mouse
Rat
Cow
otogelin like
Pig
otogelin like
Publication Statistics
PubMed Score 13.04
PubMed score by year
PubTator Score 4.35
PubTator score by year
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Related Publications
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PMID
Year
Title