You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
OTOA
Otoancorin

Protein Summary
Description
May act as an adhesion molecule. The protein encoded by this gene is specifically expressed in the inner ear, and is located at the interface between the apical surface of the inner ear sensory epithelia and their overlying acellular gels. It is prposed that this protein is involved in the attachment of the inner ear acellular gels to the apical surface of the underlying nonsensory cells. Mutations in this gene are associated with autosomal recessive deafness type 22 (DFNB22). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000286149
  • ENSP00000286149
  • ENSG00000155719
  • ENST00000388956
  • ENSP00000373608
  • ENST00000388957
  • ENSP00000373609
  • ENST00000388958
  • ENSP00000373610
  • ENST00000646100
  • ENSP00000496564

Symbol
  • CT108
  • DFNB22
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.81
tissue sample
0.6
transcription factor
0.54
cell line
0.51
cellular component
0.4


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.98   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 65   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.98   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 65   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (132)
TECTA
Tbio
Novelty:  0.02462336
Score:  0.979
Data Source:  STRINGDB
TECTB
Tbio
Novelty:  0.04489491
Score:  0.979
Data Source:  STRINGDB
OTOG
Tdark
Novelty:  0.04344519
Score:  0.91
Data Source:  STRINGDB
MSLN
Tbio
Novelty:  0.00191245
Score:  0.907
Data Source:  STRINGDB
LY6E
Tbio
Novelty:  0.00758512
Score:  0.906
Data Source:  STRINGDB
XPNPEP2
Tchem
Family:  Enzyme
Novelty:  0.01453123
Score:  0.902
Data Source:  STRINGDB
CEACAM7
Tbio
Novelty:  0.05266788
Score:  0.902
Data Source:  STRINGDB
BST1
Tbio
Family:  Enzyme
Novelty:  0.01329061
Score:  0.901
Data Source:  STRINGDB
THY1
Tbio
Novelty:  0.00032846
Score:  0.901
Data Source:  STRINGDB
NTM
Tbio
Novelty:  0.01659865
Score:  0.9
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational modification: synthesis of GPI-anchored proteins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational modification: synthesis of GPI-anchored proteins
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (8)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
0
1
88
balding measurement
1
1
1
76.5
inflammatory biomarker measurement
1
1
0
53.4
39.6
major depressive disorder
1
1
1
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1
88
balding measurement
1
76.5
inflammatory biomarker measurement
0
53.4
39.6
major depressive disorder
1
17.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
otoancorin
699600
Mouse
MGI:2149209
246190
Rat
RGD:1562741
499260
Dog
otoancorin
VGNC:44175
608655
Horse
otoancorin
VGNC:21079
100068851
Species
Name
OMA
EggNOG
Inparanoid
Macaque
otoancorin
Mouse
Rat
Dog
otoancorin
Horse
otoancorin
Publication Statistics
PubMed Score 22.98
PubMed score by year
PubTator Score 6.59
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title