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Tbio
OSTN
Osteocrin

Protein Summary
Description
Hormone that acts as a regulator of dendritic growth in the developing cerebral cortex in response to sensory experience (PubMed:27830782). Induced in the brain following membrane depolarization and inhibits dendritic branching in neurons of the developing cortex (PubMed:27830782). Probably acts by binding to natriuretic peptide receptor NPR3/NPR-C, thereby preventing binding between NPR3/NPR-C and natriuretic peptides, leading to increase cGMP production (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000339051
  • ENSP00000342356
  • ENSG00000188729

Symbol
  • MUSCLIN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.58
tissue
0.58
cell line
0.49
disease
0.37
biological term
0.36


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.58   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 86   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.58   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 86   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (30)
INS
Tbio
Novelty:  0.00000499
Score:  0.852
Data Source:  STRINGDB
NPR3
Tchem
Novelty:  0.00227442
Score:  0.751
Data Source:  STRINGDB
GMNC
Tbio
Novelty:  0.06300768
Score:  0.684
Data Source:  STRINGDB
CWC15
Tbio
Novelty:  0.00205068
Score:  0.662
Data Source:  STRINGDB
CATSPER2
Tchem
Family:  IC
Novelty:  0.03701031
Score:  0.623
Data Source:  STRINGDB
STT3B
Tbio
Family:  Enzyme
Novelty:  0.05813174
Score:  0.594
Data Source:  STRINGDB
STT3A
Tbio
Family:  Enzyme
Novelty:  0.01063504
Score:  0.592
Data Source:  STRINGDB
RNF17
Tbio
Family:  Epigenetic
Novelty:  0.09240471
Score:  0.575
Data Source:  STRINGDB
TTLL6
Tdark
Family:  Enzyme
Novelty:  0.15224272
Score:  0.549
Data Source:  STRINGDB
PHOSPHO2
Tbio
Family:  Enzyme
Novelty:  0.36911271
Score:  0.547
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (8)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cortical surface area measurement
2
2
0
17.5
91.1
brain volume measurement
10
5
10
89.9
white matter integrity
4
2
4
59
serum gamma-glutamyl transferase measurement
2
2
2
43.8
brain measurement
1
1
0
24.1
29.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cortical surface area measurement
0
17.5
91.1
brain volume measurement
10
89.9
white matter integrity
4
59
serum gamma-glutamyl transferase measurement
2
43.8
brain measurement
0
24.1
29.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
osteocrin
705210
Mouse
MGI:2677164
239790
Rat
RGD:1303110
360730
Dog
osteocrin
VGNC:44173
608280
Horse
osteocrin
VGNC:21077
100059841
Species
Name
OMA
EggNOG
Inparanoid
Macaque
osteocrin
Mouse
Rat
Dog
osteocrin
Horse
osteocrin
Publication Statistics
PubMed Score 44.58
PubMed score by year
PubTator Score 14.50
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title