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Tbio
OSTC
Oligosaccharyltransferase complex subunit OSTC

Protein Summary
Description
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. May be involved in N-glycosylation of APP (amyloid-beta precursor protein). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361564
  • ENSP00000354676
  • ENSG00000198856
  • ENST00000512478
  • ENSP00000426167

Symbol
  • DC2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
small molecule perturbation
0.92
transcription factor perturbation
0.84
histone modification site profile
0.82
virus perturbation
0.68
tissue
0.64


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 84   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 84   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (116)
ATP2B2
Tbio
Family:  Transporter
Novelty:  0.007782
p_int:  0.999406654
p_ni:  0.00059334
p_wrong:  7e-9
Data Source:  BioPlex
SLC39A9
Tbio
Family:  Transporter
Novelty:  0.06143625
p_int:  0.998178083
p_ni:  0.001760272
p_wrong:  0.000061645
Data Source:  BioPlex
KLK15
Tbio
Family:  Enzyme
Novelty:  0.00083978
p_int:  0.991920853
p_ni:  0.0080258
p_wrong:  0.000053348
Data Source:  BioPlex
SCN3B
Tbio
Family:  IC
Novelty:  0.0438123
p_int:  0.990711491
p_ni:  0.004179569
p_wrong:  0.00510894
Data Source:  BioPlex
DLK1
Tchem
Novelty:  0.00212394
p_int:  0.988537739
p_ni:  0.002390822
p_wrong:  0.009071439
Score:  0.183
Data Source:  BioPlex,STRINGDB
DPEP1
Tclin
Family:  Enzyme
Novelty:  0.00384946
p_int:  0.953572907
p_ni:  0.035400209
p_wrong:  0.011026885
Data Source:  BioPlex
ITGB2
Tclin
Novelty:  0.00185859
p_int:  0.928050967
p_ni:  0.063649418
p_wrong:  0.008299615
Data Source:  BioPlex
GYG2
Tbio
Family:  Enzyme
Novelty:  0.01520991
p_int:  0.908552532
p_ni:  0.084036385
p_wrong:  0.007411083
Score:  0.188
Data Source:  BioPlex,STRINGDB
CLEC4A
Tbio
Novelty:  0.01821643
p_int:  0.799669986
p_ni:  0.177846335
p_wrong:  0.022483679
Data Source:  BioPlex
STT3A
Tbio
Family:  Enzyme
Novelty:  0.01063504
Score:  0.976
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (1)
Find Similar Targets
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Data Source
Name
Explore in Pharos
Explore in Source
UniProt
Protein modification; protein glycosylation.
Name
Explore in Pharos
Explore in Source
Protein modification; protein glycosylation.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
1
1
0
1.1
72.6
apolipoprotein A 1 measurement
1
1
1
2
low density lipoprotein cholesterol measurement
1
1
1
1.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
0
1.1
72.6
apolipoprotein A 1 measurement
1
2
low density lipoprotein cholesterol measurement
1
1.1
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1913607
66357
Rat
RGD:1560708
362040
Dog
oligosaccharyltransferase complex non-catalytic subunit
VGNC:44170
477512
Horse
oligosaccharyltransferase complex non-catalytic subunit
VGNC:50736
100629846
Cow
oligosaccharyltransferase complex non-catalytic subunit
VGNC:32478
768033
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
oligosaccharyltransferase complex non-catalytic subunit
Horse
oligosaccharyltransferase complex non-catalytic subunit
Cow
oligosaccharyltransferase complex non-catalytic subunit
Publication Statistics
PubMed Score 16.00
PubMed score by year
PubTator Score 5.05
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title