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Tbio
OSM
Oncostatin-M

Protein Summary
Description
Growth regulator. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIPR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration (By similarity). This gene encodes a member of the leukemia inhibitory factor/oncostatin-M (LIF/OSM) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein is a secreted cytokine and growth regulator that inhibits the proliferation of a number of tumor cell lines. This protein also regulates the production of other cytokines, including interleukin 6, granulocyte-colony stimulating factor and granulocyte-macrophage colony stimulating factor in endothelial cells. This gene and t ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000215781
  • ENSP00000215781
  • ENSG00000099985
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.96
biological term
0.84
virus perturbation
0.68
PubMedID
0.62
tissue
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 539.72   (req: < 5)
Gene RIFs: 115   (req: <= 3)
Antibodies: 577   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 539.72   (req: >= 5)
Gene RIFs: 115   (req: > 3)
Antibodies: 577   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (165)
IL6ST
Tclin
Novelty:  0.01026472
p_int:  0.999999776
p_ni:  2.2e-7
p_wrong:  4e-9
Score:  0.985
Data Source:  BioPlex,Reactome,STRINGDB
C5orf22
Tdark
Novelty:  1.29325352
p_int:  0.99993194
p_ni:  0.000040495
p_wrong:  0.000027566
Score:  0.534
Data Source:  BioPlex,STRINGDB
C1QBP
Tbio
Novelty:  0.00532825
p_int:  0.998342809
p_ni:  0.001657191
Score:  0.185
Data Source:  BioPlex,STRINGDB
TRPM3
Tchem
Family:  IC
Novelty:  0.00647452
p_int:  0.982380746
p_ni:  0.000813087
p_wrong:  0.016806166
Score:  0.534
Data Source:  BioPlex,STRINGDB
ZNF579
Tdark
Family:  TF
Novelty:  4.75515836
p_int:  0.830784453
p_ni:  0.162884422
p_wrong:  0.006331125
Score:  0.198
Data Source:  BioPlex,STRINGDB
OSMR
Tbio
Novelty:  0.01554974
Score:  0.994
Data Source:  Reactome,STRINGDB
LIFR
Tbio
Novelty:  0.00514085
Score:  0.982
Data Source:  Reactome,STRINGDB
STAT3
Tchem
Family:  TF
Novelty:  0.00011808
Score:  0.982
Data Source:  STRINGDB
JAK2
Tclin
Family:  Kinase
Novelty:  0.00022894
Score:  0.957
Data Source:  Reactome,STRINGDB
JAK1
Tclin
Family:  Kinase
Novelty:  0.00093625
Score:  0.956
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets (17)
Explore Nearest Tclin Targets
Pathways (258)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
IL-6-type cytokine receptor ligand interactions
Reactome
Immune System
Reactome
Interleukin-4 and Interleukin-13 signaling
Reactome
Interleukin-6 family signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
IL-6-type cytokine receptor ligand interactions
Immune System
Interleukin-4 and Interleukin-13 signaling
Interleukin-6 family signaling
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (25)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
1
3
3
72.1
cup-to-disc ratio measurement
2
2
2
71.6
platelet crit
1
1
1
70.8
heel bone mineral density
2
2
4
70.1
2
2
1
1.1
60.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
3
72.1
cup-to-disc ratio measurement
2
71.6
platelet crit
1
70.8
heel bone mineral density
4
70.1
1
1.1
60.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
oncostatin M
VGNC:6023
736338
Macaque
oncostatin M
717994
Mouse
MGI:104749
18413
Rat
RGD:1585012
289747
Dog
oncostatin M
VGNC:44166
611921
Species
Name
OMA
EggNOG
Inparanoid
Chimp
oncostatin M
Macaque
oncostatin M
Mouse
Rat
Dog
oncostatin M
Publication Statistics
PubMed Score 539.72
PubMed score by year
PubTator Score 405.21
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title