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Tbio
OSGEP
Probable tRNA N6-adenosine threonylcarbamoyltransferase

Protein Summary
Description
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. OSGEP likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000206542
  • ENSP00000206542
  • ENSG00000092094

Symbol
  • GCPL1
  • KAE1
  • TCS3
  • GCPL1
  • GAMOS3
  • OSGEP1
  • PRSMG1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.84
cell type or tissue
0.78
histone modification site profile
0.73
transcription factor binding site profile
0.72
disease perturbation
0.62


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 100.19   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 147   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 100.19   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 147   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (114)
GON7
Tdark
Novelty:  0.21994743
p_int:  0.999999955
p_ni:  4.5e-8
Score:  0.998
Data Source:  BioPlex,STRINGDB
TPRKB
Tbio
Novelty:  0.1035085
p_int:  0.999995848
p_ni:  0.000004152
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
TP53RK
Tbio
Family:  Kinase
Novelty:  0.04302252
p_int:  0.999985246
p_ni:  0.000014754
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
NUP43
Tbio
Novelty:  0.11571309
p_int:  0.999615467
p_ni:  0.000384533
Score:  0.756
Data Source:  BioPlex,STRINGDB
LAGE3
Tdark
Novelty:  0.02099961
p_int:  0.998094493
p_ni:  0.001905508
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
HYKK
Tbio
Family:  Enzyme
Novelty:  0.11408577
p_int:  0.993394731
p_ni:  0.000357989
p_wrong:  0.006247279
Score:  0.625
Data Source:  BioPlex,STRINGDB
CYTH4
Tbio
Novelty:  0.05783135
p_int:  0.941884147
p_ni:  0.058115853
Data Source:  BioPlex
POP7
Tbio
Family:  Enzyme
Novelty:  0.05460002
p_int:  0.939175897
p_ni:  0.060822439
p_wrong:  0.000001664
Score:  0.268
Data Source:  BioPlex,STRINGDB
CCDC28B
Tbio
Novelty:  0.16787198
p_int:  0.931968792
p_ni:  0.068031208
Score:  0.622
Data Source:  BioPlex,STRINGDB
CCDC28A
Tdark
Novelty:  0.47441753
p_int:  0.825039393
p_ni:  0.174960607
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
tRNA modification in the nucleus and cytosol
Reactome
tRNA processing
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
tRNA modification in the nucleus and cytosol
tRNA processing
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mitochondrial DNA measurement
1
1
1
73.6
metabolite measurement
1
1
1
65.6
aspartate aminotransferase measurement
2
1
1
6.8
62.1
1
1
0
1.6
27.3
serum alanine aminotransferase measurement
1
1
0
5.6
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mitochondrial DNA measurement
1
73.6
metabolite measurement
1
65.6
aspartate aminotransferase measurement
1
6.8
62.1
0
1.6
27.3
serum alanine aminotransferase measurement
0
5.6
21.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
O-sialoglycoprotein endopeptidase
VGNC:12568
473320
Macaque
O-sialoglycoprotein endopeptidase
702512
Mouse
MGI:1913496
66246
Rat
RGD:1308578
290028
Dog
O-sialoglycoprotein endopeptidase
VGNC:44163
100687555
Species
Name
OMA
EggNOG
Inparanoid
Chimp
O-sialoglycoprotein endopeptidase
Macaque
O-sialoglycoprotein endopeptidase
Mouse
Rat
Dog
O-sialoglycoprotein endopeptidase
Publication Statistics
PubMed Score 100.19
PubMed score by year
PubTator Score 28.33
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title