Pharos : Target Details

Tdark

Protein Summary

Uniprot Accession IDs

Gene Name

OSER1

Ensembl ID

ENST00000255174
ENSP00000255174
ENSG00000132823
ENST00000372970
ENSP00000362061

Symbol

C20orf111
Osr1
Perit1
HSPC207
C20orf111
dJ1183I21.1

Illumination Graph

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	1

transcription factor binding site profile	0.88

transcription factor perturbation	0.74

histone modification site profile	0.73

cellular component	0.68

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.31 (req: < 5)

View Publications

Gene RIFs: 0 (req: <= 3)

Antibodies: 69 (req: <= 50)

View Antibodies

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.31 (req: >= 5)

Gene RIFs: 0 (req: > 3)

Antibodies: 69 (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

View Data

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Go To Tool

Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (23)

Explore Interacting Targets

1 – 10 of 23

See Interactions on String-DB

LACC1

Tbio

Family: Enzyme

Novelty: 0.03928871

p_int: 0.999999999

p_ni: 1e-9

Score: 0.179

Data Source: BioPlex,STRINGDB

PSMB9

Tchem

Family: Enzyme

Novelty: 0.0016249

p_int: 0.999924324

p_ni: 0.000075654

p_wrong: 2.2e-8

Score: 0.23

Data Source: BioPlex,STRINGDB

PSMB3

Tbio

Family: Enzyme

Novelty: 0.12791198

p_int: 0.999914353

p_ni: 0.000084219

p_wrong: 0.000001428

Score: 0.258

Data Source: BioPlex,STRINGDB

TSR3

Tdark

Novelty: 0.09337944

p_int: 0.887949587

p_ni: 0.112050413

Score: 0.19

Data Source: BioPlex,STRINGDB

TRMT13

Tdark

Novelty: 3.91234304

p_int: 0.820940853

p_ni: 0.000512059

p_wrong: 0.178547088

Score: 0.359

Data Source: BioPlex,STRINGDB

ZFAND2B

Tbio

Novelty: 0.28286118

Score: 0.817

Data Source: STRINGDB

ZFAND2A

Tbio

Novelty: 0.12605439

Score: 0.755

Data Source: STRINGDB

ARHGAP17

Tbio

Family: Enzyme

Novelty: 0.06611987

Score: 0.636

Data Source: STRINGDB

C1orf174

Tdark

Novelty: 4.20172485

Score: 0.53

Data Source: STRINGDB

ROMO1

Tbio

Novelty: 0.01909602

Score: 0.52

Data Source: STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (0)

No GO Terms found

Disease Associations (null)

No disease associations found

GWAS Traits (16)

Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

1 – 5 of 16

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Evidence (Mean Rank Score)
monocyte count	EFO_0005091	2	2	2	90.4

granulocyte percentage of myeloid white cells	EFO_0007997	1	2	2	84.7

monocyte percentage of leukocytes	EFO_0007989	2	2	3	84.3

mean corpuscular volume	EFO_0004526	1	2	2	79.6

lymphocyte count	EFO_0004587	2	2	2	65.6

Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

1 – 5 of 16

GWAS Trait	EFO ID	Beta Count	Evidence (Mean Rank Score)
monocyte count	EFO_0005091	2	90.4

granulocyte percentage of myeloid white cells	EFO_0007997	2	84.7

monocyte percentage of leukocytes	EFO_0007989	3	84.3

mean corpuscular volume	EFO_0004526	2	79.6

lymphocyte count	EFO_0004587	2	65.6

Beta Count

Odds Ratio

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UniProt Keyword

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GWAS Trait

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No Header	No Header
Agents acting on the renin-angiotensin system use measurement

Calcium channel blocker use measurement

diastolic blood pressure

Diuretic use measurement

granulocyte percentage of myeloid white cells

lymphocyte count

lymphocyte percentage of leukocytes

mean arterial pressure

mean corpuscular volume

mean reticulocyte volume

IDG Resources

No IDG generated resources found

Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID
Chimp	oxidative stress responsive serine rich 1	VGNC:9937	458266

Macaque	oxidative stress responsive serine rich 1		693890

Mouse	oxidative stress responsive serine rich 1	MGI:1913930	66680

Rat	oxidative stress responsive serine-rich 1	RGD:1303142	296346

Dog	oxidative stress responsive serine rich 1	VGNC:44162	100687504

Species	Name	OMA	EggNOG	Inparanoid
Chimp	oxidative stress responsive serine rich 1

Macaque	oxidative stress responsive serine rich 1

Mouse	oxidative stress responsive serine rich 1

Rat	oxidative stress responsive serine-rich 1

Dog	oxidative stress responsive serine rich 1

Publication Statistics

PubMed Score 4.31

PubMed score by year

PubTator Score 1.00

PubTator score by year

Related Publications

Text Mined References (8)

Items per page:

0 of 0

PMID	Year	Title

No Header	No Header
Complete proteome

Phosphoprotein

Polymorphism

Reference proteome