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Tbio
OSBPL9
Oxysterol-binding protein-related protein 9

Protein Summary
Description
This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although some members contain only the sterol-binding domain. This family member functions as a cholesterol transfer protein that regulates Golgi structure and function. Multiple transcript variants, most of which encode distinct isoforms, have been identified. Related pseudogenes have been identified on chromosomes 3, 11 and 12. [provided by RefSeq, Jul 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361556
  • ENSP00000354970
  • ENSG00000117859
  • ENST00000371714
  • ENSP00000360779
  • ENST00000428468
  • ENSP00000407168
  • ENST00000447887
  • ENSP00000412733
  • ENST00000453295
  • ENSP00000413263
  • ENST00000462759
  • ENSP00000433279
  • ENST00000486942
  • ENSP00000431980
  • ENST00000531828
  • ENSP00000433083

Symbol
  • ORP9
  • OSBP4
  • ORP9
  • ORP-9
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.84
transcription factor
0.82
kinase perturbation
0.76
virus perturbation
0.76
transcription factor binding site profile
0.67


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.65   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 124   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.65   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 124   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (20)
VAPB
Tbio
Novelty:  0.00542377
p_int:  0.999999993
p_ni:  3e-9
p_wrong:  4e-9
Score:  0.85
Data Source:  BioPlex,STRINGDB
VAPA
Tbio
Novelty:  0.00169209
p_int:  0.999999715
p_ni:  2.83e-7
p_wrong:  2e-9
Score:  0.827
Data Source:  BioPlex,STRINGDB
FUZ
Tbio
Novelty:  0.03001976
p_int:  0.999998538
p_ni:  0.000001461
p_wrong:  2e-9
Score:  0.165
Data Source:  BioPlex,STRINGDB
DNAJA1
Tchem
Novelty:  0.00894126
p_int:  0.999778276
p_ni:  0.000205877
p_wrong:  0.000015847
Score:  0.332
Data Source:  BioPlex,STRINGDB
CFAP36
Tdark
Novelty:  0.42842118
p_int:  0.998945984
p_ni:  0.001054014
p_wrong:  2e-9
Score:  0.197
Data Source:  BioPlex,STRINGDB
WRAP73
Tbio
Novelty:  0.25394934
p_int:  0.997186749
p_ni:  0.002813243
p_wrong:  8e-9
Score:  0.169
Data Source:  BioPlex,STRINGDB
ISCA2
Tbio
Novelty:  0.02194373
p_int:  0.995060285
p_ni:  0.003391202
p_wrong:  0.001548513
Data Source:  BioPlex
CYP1A1
Tchem
Novelty:  0.0002404
p_int:  0.972445347
p_ni:  0.024308528
p_wrong:  0.003246125
Score:  0.153
Data Source:  BioPlex,STRINGDB
ZBTB37
Tdark
Family:  TF
Novelty:  1.0414887
Score:  0.788
Data Source:  STRINGDB
DARS2
Tbio
Family:  Enzyme
Novelty:  0.01588438
Score:  0.692
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Bile acid and bile salt metabolism (R-HSA-194068)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Bile acid and bile salt metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Metabolism of steroids
Reactome
Synthesis of bile acids and bile salts
Name
Explore in Pharos
Explore in Source
Bile acid and bile salt metabolism
Metabolism
Metabolism of lipids
Metabolism of steroids
Synthesis of bile acids and bile salts
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (9)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
1
1
75.6
1
1
0
1
70.8
lymphocyte count
2
2
2
61.8
BMI-adjusted hip circumference
2
2
2
60.1
electrocardiography
1
1
6
44.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
75.6
0
1
70.8
lymphocyte count
2
61.8
BMI-adjusted hip circumference
2
60.1
electrocardiography
6
44.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
oxysterol binding protein like 9
VGNC:6140
469322
Macaque
oxysterol binding protein like 9
714969
Mouse
MGI:1923784
100273
Rat
RGD:1311508
298369
Dog
oxysterol binding protein like 9
VGNC:44159
475355
Species
Name
OMA
EggNOG
Inparanoid
Chimp
oxysterol binding protein like 9
Macaque
oxysterol binding protein like 9
Mouse
Rat
Dog
oxysterol binding protein like 9
Publication Statistics
PubMed Score 13.65
PubMed score by year
PubTator Score 7.57
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title