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Tbio
OSBPL8
Oxysterol-binding protein-related protein 8

Protein Summary
Description
Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner (PubMed:26206935). Binds oxysterol, 25-hydroxycholesterol and cholesterol (PubMed:17428193, PubMed:17991739, PubMed:21698267). This gene encodes a member of a family of proteins containing an N-terminal pleckstrin homology domain and a highly conserved C-terminal oxysterol-binding protein-like sterol-binding domain. It binds mutliple lipid-containing molecules, including phosphatidylserine, phosphatidylinositol 4-phosphate (PI4P) and oxysterol, and promotes their exchange between the endoplasmic reticulum and the plasma membrane. Alternative splicing results in multiple tran ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261183
  • ENSP00000261183
  • ENSG00000091039
  • ENST00000393249
  • ENSP00000376939
  • ENST00000393250
  • ENSP00000376940
  • ENST00000611266
  • ENSP00000478240

Symbol
  • KIAA1451
  • ORP8
  • OSBP10
  • ORP8
  • MST120
  • OSBP10
  • MSTP120
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.96
microRNA
0.9
transcription factor binding site profile
0.84
disease perturbation
0.79
histone modification site profile
0.73


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.34   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 92   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.34   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 92   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (53)
OSBPL5
Tbio
Novelty:  0.05262202
p_int:  0.999996367
p_ni:  0.000003633
Score:  0.406
Data Source:  BioPlex,STRINGDB
HADHA
Tbio
Novelty:  0.00385746
p_int:  0.999759809
p_ni:  0.000240191
Data Source:  BioPlex
PCDHGB2
Tdark
Novelty:  1.16587709
p_int:  0.998946353
p_ni:  0.001053647
Data Source:  BioPlex
SPPL2B
Tchem
Family:  Enzyme
Novelty:  0.0274774
p_int:  0.997730815
p_ni:  0.002269185
Data Source:  BioPlex
ADGRG5
Tdark
Family:  GPCR
Novelty:  0.26575982
p_int:  0.994532549
p_ni:  0.005467451
Data Source:  BioPlex
SDC2
Tbio
Novelty:  0.00597758
p_int:  0.984903236
p_ni:  0.015096764
Data Source:  BioPlex
ASIC4
Tbio
Family:  IC
Novelty:  0.02912816
p_int:  0.976716635
p_ni:  0.023283365
Data Source:  BioPlex
ZNRF4
Tbio
Novelty:  0.16505328
p_int:  0.976428171
p_ni:  0.023571829
Data Source:  BioPlex
GPR183
Tchem
Family:  GPCR
Novelty:  0.02005679
p_int:  0.965987592
p_ni:  0.034012406
p_wrong:  1e-9
Data Source:  BioPlex
PTGER3
Tclin
Family:  GPCR
Novelty:  0.0012681
p_int:  0.965126842
p_ni:  0.034873158
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Acyl chain remodelling of PS (R-HSA-1482801)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Acyl chain remodelling of PS
Reactome
Glycerophospholipid biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Phospholipid metabolism
Name
Explore in Pharos
Explore in Source
Acyl chain remodelling of PS
Glycerophospholipid biosynthesis
Metabolism
Metabolism of lipids
Phospholipid metabolism
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (25)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
basophil count
2
1
2
11.9
basophil percentage of leukocytes
1
1
1
10.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
basophil count
2
11.9
basophil percentage of leukocytes
1
10.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
oxysterol binding protein like 8
VGNC:5519
452085
Macaque
oxysterol binding protein like 8
693338
Mouse
MGI:2443807
237542
Dog
oxysterol binding protein like 8
VGNC:44158
475408
Horse
oxysterol binding protein like 8
VGNC:21069
100059086
Species
Name
OMA
EggNOG
Inparanoid
Chimp
oxysterol binding protein like 8
Macaque
oxysterol binding protein like 8
Mouse
Dog
oxysterol binding protein like 8
Horse
oxysterol binding protein like 8
Publication Statistics
PubMed Score 22.34
PubMed score by year
PubTator Score 8.85
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title