OSBPL6
Oxysterol-binding protein-related protein 6
Protein Summary
Weakly binds 25-hydroxycholesterol. This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. Transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
- ENST00000190611
- ENSP00000190611
- ENSG00000079156
- ENST00000315022
- ENSP00000318723
- ENST00000357080
- ENSP00000349591
- ENST00000359685
- ENSP00000352713
- ENST00000392505
- ENSP00000376293
- ENST00000409045
- ENSP00000387248
- ENST00000409631
- ENSP00000386885
- ORP6
- ORP6
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
virus perturbation | 0.97 | ||
trait | 0.86 | ||
histone modification site profile | 0.84 | ||
kinase perturbation | 0.81 | ||
transcription factor binding site profile | 0.75 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3.93 (req: < 5)
Gene RIFs: 5 (req: <= 3)
Antibodies: 122 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3.93 (req: >= 5)
Gene RIFs: 5 (req: > 3)
Antibodies: 122 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (49)
VAPB
Novelty: 0.00542377
p_int: 0.999999979
p_ni: 2.1e-8
Score: 0.776
Data Source: BioPlex,STRINGDB
VAPA
Novelty: 0.00169209
p_int: 0.999994879
p_ni: 0.000005121
Score: 0.747
Data Source: BioPlex,STRINGDB
TRAF1
Novelty: 0.00526776
p_int: 0.99996382
p_ni: 0.00003618
Score: 0.154
Data Source: BioPlex,STRINGDB
ZFPL1
Novelty: 0.1829181
p_int: 0.999376642
p_ni: 0.000623358
Score: 0.165
Data Source: BioPlex,STRINGDB
ILVBL
Family: Enzyme
Novelty: 0.00297467
p_int: 0.998548627
p_ni: 0.001451373
Data Source: BioPlex
AURKA
Family: Kinase
Novelty: 0.0010868
p_int: 0.997759669
p_ni: 0.002240331
Data Source: BioPlex
Nearest Tclin Targets
Pathways (5)
Reactome (5)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Bile acid and bile salt metabolism | ||||
Reactome | Metabolism | ||||
Reactome | Metabolism of lipids | ||||
Reactome | Metabolism of steroids | ||||
Reactome | Synthesis of bile acids and bile salts | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Bile acid and bile salt metabolism | ||||
Metabolism | ||||
Metabolism of lipids | ||||
Metabolism of steroids | ||||
Synthesis of bile acids and bile salts | ||||
Viral Interactions (0)
Gene Ontology Terms (12)
Functions (4)
Components (7)
Processes (1)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations (null)
GWAS Traits (9)
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
aspartate aminotransferase measurement | 1 | 1 | 0 | 8.1 | 65.6 | ||||
vital capacity | 1 | 1 | 1 | 47.7 | |||||
refractive error measurement | 1 | 1 | 1 | 38.2 | |||||
electrocardiography | 1 | 1 | 3 | 30.2 | |||||
forced expiratory volume | 1 | 1 | 1 | 30.2 | |||||
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
aspartate aminotransferase measurement | 0 | 8.1 | 65.6 | ||||
vital capacity | 1 | 47.7 | |||||
refractive error measurement | 1 | 38.2 | |||||
electrocardiography | 3 | 30.2 | |||||
forced expiratory volume | 1 | 30.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | oxysterol binding protein like 6 | VGNC:2742 | 459775 | |||||
Macaque | oxysterol binding protein like 6 | 708349 | ||||||
Mouse | MGI:2139014 | 99031 | ||||||
Rat | RGD:1308887 | 311129 | ||||||
Dog | oxysterol binding protein like 6 | VGNC:44156 | 478816 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | oxysterol binding protein like 6 | |||||
Macaque | oxysterol binding protein like 6 | |||||
Mouse | ||||||
Rat | ||||||
Dog | oxysterol binding protein like 6 | |||||
Publication Statistics
PubMed Score 3.93
PubMed score by year
PubTator Score 3.81
PubTator score by year
Related Publications
Text Mined References (13)
GeneRif Annotations (5)
Items per page:
0 of 0
PMID | Year | Title |
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