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Tbio
OSBPL5
Oxysterol-binding protein-related protein 5

Protein Summary
Description
Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner (PubMed:23934110, PubMed:26206935). May cooperate with NPC1 to mediate the exit of cholesterol from endosomes/lysosomes (PubMed:21220512). Binds 25-hydroxycholesterol and cholesterol (PubMed:17428193). This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors that play a key role in the maintenance of cholesterol balance in the body. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. This gene has been shown to be imprinted, with preferentia ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263650
  • ENSP00000263650
  • ENSG00000021762
  • ENST00000348039
  • ENSP00000302872
  • ENST00000389989
  • ENSP00000374639
  • ENST00000525498
  • ENSP00000433342

Symbol
  • KIAA1534
  • OBPH1
  • ORP5
  • ORP5
  • OBPH1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein) perturbation
0.83
virus perturbation
0.64
cell line
0.63
protein domain
0.58
disease perturbation
0.56


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.81   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 77   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.81   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 77   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (55)
PRR11
Tbio
Novelty:  0.05077483
p_int:  0.999999741
p_ni:  2.58e-7
Data Source:  BioPlex
OSBPL8
Tbio
Novelty:  0.06812531
p_int:  0.999996367
p_ni:  0.000003633
Score:  0.406
Data Source:  BioPlex,STRINGDB
NAGLU
Tbio
Family:  Enzyme
Novelty:  0.01033079
p_int:  0.999812115
p_ni:  0.000187885
Score:  0.229
Data Source:  BioPlex,STRINGDB
PLD1
Tchem
Family:  Enzyme
Novelty:  0.00608142
p_int:  0.963670977
p_ni:  0.036329023
Score:  0.341
Data Source:  BioPlex,STRINGDB
KLHL23
Tdark
Novelty:  0.64141058
p_int:  0.887049233
p_ni:  0.112950746
p_wrong:  2.1e-8
Score:  0.194
Data Source:  BioPlex,STRINGDB
NPC1
Tchem
Novelty:  0.00155015
Score:  0.965
Data Source:  STRINGDB
TSSC4
Tdark
Novelty:  0.17064786
Score:  0.725
Data Source:  STRINGDB
NAP1L4
Tbio
Novelty:  0.08710866
Score:  0.696
Data Source:  STRINGDB
SACM1L
Tbio
Family:  Enzyme
Novelty:  0.00499867
Score:  0.688
Data Source:  STRINGDB
PHLDA2
Tbio
Novelty:  0.01847579
Score:  0.665
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Acyl chain remodelling of PS (R-HSA-1482801)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Acyl chain remodelling of PS
Reactome
Glycerophospholipid biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Phospholipid metabolism
Name
Explore in Pharos
Explore in Source
Acyl chain remodelling of PS
Glycerophospholipid biosynthesis
Metabolism
Metabolism of lipids
Phospholipid metabolism
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (19)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Non-traceable Author Statement (NAS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
migraine disorder
1
1
0
1
74
calcium measurement
2
1
2
65.7
aspartate aminotransferase measurement
1
1
0
6.7
38.8
sex hormone-binding globulin measurement
1
1
1
9.1
bilirubin measurement
1
1
1
4.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
migraine disorder
0
1
74
calcium measurement
2
65.7
aspartate aminotransferase measurement
0
6.7
38.8
sex hormone-binding globulin measurement
1
9.1
bilirubin measurement
1
4.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
oxysterol binding protein like 5
706613
Mouse
MGI:1930265
79196
Rat
RGD:1308402
361686
Horse
oxysterol binding protein like 5
VGNC:21066
100147251
Cow
oxysterol binding protein like 5
VGNC:32463
532690
Species
Name
OMA
EggNOG
Inparanoid
Macaque
oxysterol binding protein like 5
Mouse
Rat
Horse
oxysterol binding protein like 5
Cow
oxysterol binding protein like 5
Publication Statistics
PubMed Score 27.81
PubMed score by year
PubTator Score 13.43
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title