Tbio OSBPL2 Oxysterol-binding protein-related protein 2

Protein Summary

Description

Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate (PubMed:11279184). Binds 25-hydroxycholesterol (PubMed:17428193). This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although the encoded protein contains only the sterol-binding domain. In vitro studies have shown that the encoded protein can bind strongly to phosphatic acid and weakly to phosphatidylinositol 3-phosphate, but cannot bind to 25-hydroxycholesterol. The protein associates with the Golgi apparatus. Transcript variants encoding different isoforms have been described. [provided by RefSeq, Sep 2014]

Uniprot Accession IDs

• Q9H1P3
• A8K736
• Q6IBT0
• Q9BZB1
• Q9Y4B8
• ORP-2

Gene Name

• OSBPL2

Ensembl ID

• ENST00000313733
• ENSP00000316649
• ENSG00000130703
• ENST00000358053
• ENSP00000350755
• ENST00000643412
• ENSP00000494549
• ENST00000643981
• ENSP00000495379

Symbol

• KIAA0772
• ORP2
• ORP2
• ORP-2
• DFNA67
• DNFA67

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.99
disease perturbation	0.87
virus perturbation	0.72
tissue sample	0.68
transcription factor perturbation	0.68

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.53   (req: < 5)

Gene RIFs: 20   (req: <= 3)

Antibodies: 165   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.53   (req: >= 5)

Gene RIFs: 20   (req: > 3)

Antibodies: 165   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0