OSBP2
Oxysterol-binding protein 2
Protein Summary
Binds 7-ketocholesterol. The protein encoded by this gene contains a pleckstrin homology (PH) domain and an oxysterol-binding region. It binds oxysterols such as 7-ketocholesterol and may inhibit their cytotoxicity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2013]
- ENST00000332585
- ENSP00000332576
- ENSG00000184792
- ENST00000401475
- ENSP00000385254
- ENST00000437268
- ENSP00000389200
- ENST00000438716
- ENSP00000411052
- ENST00000446658
- ENSP00000392080
- ENST00000535268
- ENSP00000438713
- KIAA1664
- ORP4
- OSBPL4
- HLM
- ORP4
- ORP-4
- OSBPL1
- OSBPL4
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
histone modification site profile | 0.82 | ||
tissue | 0.68 | ||
microRNA | 0.62 | ||
cell line | 0.61 | ||
phenotype | 0.58 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 39.3 (req: < 5)
Gene RIFs: 13 (req: <= 3)
Antibodies: 107 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 39.3 (req: >= 5)
Gene RIFs: 13 (req: > 3)
Antibodies: 107 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (60)
VAPA
Novelty: 0.00169209
p_int: 0.999999606
p_ni: 4.6e-8
p_wrong: 3.49e-7
Score: 0.921
Data Source: BioPlex,STRINGDB
VAPB
Novelty: 0.00542377
p_int: 0.999993642
p_ni: 1.4e-8
p_wrong: 0.000006344
Score: 0.81
Data Source: BioPlex,STRINGDB
BTNL8
Novelty: 0.40339869
p_int: 0.9998457
p_ni: 0.000002492
p_wrong: 0.000151808
Score: 0.189
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (11)
Functions (4)
Components (6)
Processes (1)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations (null)
GWAS Traits (8)
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mathematical ability | 3 | 2 | 3 | 74.7 | |||||
mean reticulocyte volume | 1 | 2 | 2 | 72.9 | |||||
1 | 1 | 0 | 2 | 52.7 | |||||
self reported educational attainment | 1 | 1 | 1 | 51.7 | |||||
red blood cell distribution width | 1 | 1 | 1 | 48.5 | |||||
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mathematical ability | 3 | 74.7 | |||||
mean reticulocyte volume | 2 | 72.9 | |||||
0 | 2 | 52.7 | |||||
self reported educational attainment | 1 | 51.7 | |||||
red blood cell distribution width | 1 | 48.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | oxysterol binding protein 2 | VGNC:12907 | 470181 | |||||
Macaque | oxysterol binding protein 2 | 716252 | ||||||
Mouse | MGI:1921559 | 74309 | ||||||
Rat | RGD:1310505 | 305475 | ||||||
Dog | oxysterol binding protein 2 | VGNC:44150 | 477541 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | oxysterol binding protein 2 | |||||
Macaque | oxysterol binding protein 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | oxysterol binding protein 2 | |||||
Publication Statistics
PubMed Score 39.30
PubMed score by year
PubTator Score 59.50
PubTator score by year
Related Publications
Text Mined References (28)
GeneRif Annotations (13)
Items per page:
0 of 0
PMID | Year | Title |
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