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Tbio
ORMDL3
ORM1-like protein 3

Protein Summary
Description
Negative regulator of sphingolipid synthesis. May indirectly regulate endoplasmic reticulum-mediated Ca(+2) signaling.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000304046
  • ENSP00000304858
  • ENSG00000172057
  • ENST00000394169
  • ENSP00000377724
  • ENST00000579695
  • ENSP00000464693
  • ENST00000584220
  • ENSP00000464455
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.9
cellular component
0.75
histone modification site profile
0.69
tissue sample
0.66
transcription factor
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 147.55   (req: < 5)
Gene RIFs: 60   (req: <= 3)
Antibodies: 100   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 147.55   (req: >= 5)
Gene RIFs: 60   (req: > 3)
Antibodies: 100   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0