Tbio ORMDL3 ORM1-like protein 3

Protein Summary

Description

Negative regulator of sphingolipid synthesis. May indirectly regulate endoplasmic reticulum-mediated Ca(+2) signaling.

Uniprot Accession IDs

• Q8N138
• B3KS83
• Q6UY83

Gene Name

• ORMDL3

Ensembl ID

• ENST00000304046
• ENSP00000304858
• ENSG00000172057
• ENST00000394169
• ENSP00000377724
• ENST00000579695
• ENSP00000464693
• ENST00000584220
• ENSP00000464455

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.9
cellular component	0.75
histone modification site profile	0.69
tissue sample	0.66
transcription factor	0.66

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 147.55   (req: < 5)

Gene RIFs: 87   (req: <= 3)

Antibodies: 100   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 147.55   (req: >= 5)

Gene RIFs: 87   (req: > 3)

Antibodies: 100   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0