You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
ORMDL1
ORM1-like protein 1

Protein Summary
Description
Negative regulator of sphingolipid synthesis.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000325795
  • ENSP00000326869
  • ENSG00000128699
  • ENST00000392349
  • ENSP00000376160
  • ENST00000392350
  • ENSP00000376161
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.94
histone modification site profile
0.88
cell type or tissue
0.8
gene perturbation
0.74
disease perturbation
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.56   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 63   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.56   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 63   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (55)
DCUN1D5
Tchem
Novelty:  0.56719852
p_int:  0.957974136
p_ni:  0.042000315
p_wrong:  0.000025549
Score:  0.209
Data Source:  BioPlex,STRINGDB
SLC22A9
Tbio
Family:  Transporter
Novelty:  0.02212992
p_int:  0.873401995
p_ni:  0.000034461
p_wrong:  0.126563544
Score:  0.159
Data Source:  BioPlex,STRINGDB
SLC2A9
Tbio
Family:  Transporter
Novelty:  0.00683926
p_int:  0.871784659
p_ni:  0.000603305
p_wrong:  0.127612036
Data Source:  BioPlex
NEMF
Tbio
Novelty:  0.05052246
p_int:  0.854135226
p_ni:  0.145864774
Score:  0.199
Data Source:  BioPlex,STRINGDB
TTC33
Tdark
Novelty:  0.31237949
p_int:  0.842203136
p_ni:  0.157790973
p_wrong:  0.00000589
Score:  0.207
Data Source:  BioPlex,STRINGDB
SPTLC1
Tchem
Family:  Enzyme
Novelty:  0.00639691
Score:  0.92
Data Source:  STRINGDB
ORM2
Tbio
Novelty:  0.00837073
Score:  0.904
Data Source:  STRINGDB
ORM1
Tbio
Novelty:  0.007451
Score:  0.89
Data Source:  STRINGDB
SPTLC2
Tchem
Family:  Enzyme
Novelty:  0.01236952
Score:  0.845
Data Source:  STRINGDB
SPTSSA
Tbio
Family:  Enzyme
Novelty:  0.13352078
Score:  0.833
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Sphingolipid de novo biosynthesis
Reactome
Sphingolipid metabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of lipids
Sphingolipid de novo biosynthesis
Sphingolipid metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
ferritin measurement
1
1
1
42.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
ferritin measurement
1
42.3
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ORMDL sphingolipid biosynthesis regulator 1
VGNC:2740
744280
Macaque
ORMDL sphingolipid biosynthesis regulator 1
709832
Mouse
MGI:2181669
227102
Dog
ORMDL sphingolipid biosynthesis regulator 1
VGNC:44146
606834
Horse
ORMDL sphingolipid biosynthesis regulator 1
VGNC:21056
100069307
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ORMDL sphingolipid biosynthesis regulator 1
Macaque
ORMDL sphingolipid biosynthesis regulator 1
Mouse
Dog
ORMDL sphingolipid biosynthesis regulator 1
Horse
ORMDL sphingolipid biosynthesis regulator 1
Publication Statistics
PubMed Score 8.56
PubMed score by year
PubTator Score 3.65
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title