Tchem ORAI2 Protein orai-2

Protein Summary

Description

Ca(2+) release-activated Ca(2+)-like (CRAC-like) channel subunit which mediates Ca(2+) influx and increase in Ca(2+)-selective current by synergy with the Ca(2+) sensor, STIM1.

Uniprot Accession IDs

• Q96SN7
• Q6IA68
• Q8WY94
• Q9H9Y3

Gene Name

• ORAI2

Ensembl ID

• ENST00000356387
• ENSP00000348752
• ENSG00000160991
• ENST00000403646
• ENSP00000385489
• ENST00000473939
• ENSP00000417928
• ENST00000478730
• ENSP00000418140
• ENST00000611770
• ENSP00000478113

Symbol

• C7orf19
• CBCIP2
• TMEM142B
• CBCIP2
• C7orf19
• MEM142B
• TMEM142B

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.91
kinase perturbation	0.84
histone modification site profile	0.76
tissue sample	0.63
microRNA	0.62

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.07   (req: < 5)

Gene RIFs: 18   (req: <= 3)

Antibodies: 145   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.07   (req: >= 5)

Gene RIFs: 18   (req: > 3)

Antibodies: 145   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0