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Tdark
OR1A2
Olfactory receptor 1A2

Protein Summary
Description
Odorant receptor. Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000381951
  • ENSP00000371377
  • ENSG00000172150

Symbol
  • OR17-6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue
0.92
cell type or tissue
0.41
chemical
0.41
protein domain
0.41
biological term
0.33


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.3   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 26   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.3   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 26   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (32)
EMC4
Tbio
Novelty:  0.12174476
p_int:  0.9957874
p_ni:  0.00418661
p_wrong:  0.00002599
Data Source:  BioPlex
MINDY1
Tbio
Novelty:  0.31540765
p_int:  0.943187592
p_ni:  0.0563131
p_wrong:  0.000499309
Data Source:  BioPlex
EMC8
Tbio
Novelty:  0.2452967
p_int:  0.892256852
p_ni:  0.107730512
p_wrong:  0.000012636
Data Source:  BioPlex
EMC10
Tbio
Novelty:  0.04986528
p_int:  0.843637952
p_ni:  0.044336932
p_wrong:  0.112025116
Data Source:  BioPlex
EMC3
Tbio
Novelty:  0.01113829
p_int:  0.771427378
p_ni:  0.227619643
p_wrong:  0.000952978
Data Source:  BioPlex
RTP2
Tbio
Novelty:  0.05972678
Score:  0.949
Data Source:  STRINGDB
RTP1
Tbio
Novelty:  0.0278378
Score:  0.928
Data Source:  STRINGDB
GNAL
Tbio
Novelty:  0.01757098
Score:  0.913
Data Source:  STRINGDB
GNGT1
Tbio
Novelty:  0.05291961
Score:  0.906
Data Source:  STRINGDB
REEP1
Tbio
Novelty:  0.02280713
Score:  0.904
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
G alpha (s) signalling events (R-HSA-418555)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
Olfactory Signaling Pathway
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Name
Explore in Pharos
Explore in Source
G alpha (s) signalling events
GPCR downstream signalling
Olfactory Signaling Pathway
Signal Transduction
Signaling by GPCR
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubMed Score 5.30
PubMed score by year
PubTator Score 24.81
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title