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Tbio
OPTN
Optineurin

Protein Summary
Description
Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8 (PubMed:27534431). Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation (PubMed:27534431). Plays a role in the activation of innate immune response during viral infection. Mechanistically, recruits TBK1 at the Golgi apparatus, promoting its trans-phosphorylation after RLR or TLR3 stimulation (PubMed:27538435). In turn, activated TBK1 phosphorylates its downstream partner IRF3 to produce IFN-beta. Plays a neuroprotective role in the eye and optic nerve. May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin (HD). Mediates the interaction of Rab8 with the probable GTPase-activating protein TBC1D17 during Rab8-mediated endocytic trafficking, such as of transferrin receptor (TFRC/TfR); regulates Rab8 recruitment to tubules emanating from t ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263036
  • ENSP00000263036
  • ENSG00000123240
  • ENST00000378747
  • ENSP00000368021
  • ENST00000378748
  • ENSP00000368022
  • ENST00000378752
  • ENSP00000368027
  • ENST00000378757
  • ENSP00000368032
  • ENST00000378764
  • ENSP00000368040

Symbol
  • FIP2
  • GLC1E
  • HIP7
  • HYPL
  • NRP
  • NRP
  • FIP2
  • HIP7
  • HYPL
  • ALS12
  • GLC1E
  • TFIIIA-INTP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
transcription factor perturbation
0.98
disease perturbation
0.95
kinase perturbation
0.91
cellular component
0.82


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1691.63   (req: < 5)
Gene RIFs: 132   (req: <= 3)
Antibodies: 320   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1691.63   (req: >= 5)
Gene RIFs: 132   (req: > 3)
Antibodies: 320   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0