Protein Summary
Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8 (PubMed:27534431). Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation (PubMed:27534431). Plays a role in the activation of innate immune response during viral infection. Mechanistically, recruits TBK1 at the Golgi apparatus, promoting its trans-phosphorylation after RLR or TLR3 stimulation (PubMed:27538435). In turn, activated TBK1 phosphorylates its downstream partner IRF3 to produce IFN-beta. Plays a neuroprotective role in the eye and optic nerve. May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin (HD). Mediates the interaction of Rab8 with the probable GTPase-activating protein TBC1D17 during Rab8-mediated endocytic trafficking, such as of transferrin receptor (TFRC/TfR); regulates Rab8 recruitment to tubules emanating from t ...more
- ENST00000263036
- ENSP00000263036
- ENSG00000123240
- ENST00000378747
- ENSP00000368021
- ENST00000378748
- ENSP00000368022
- ENST00000378752
- ENSP00000368027
- ENST00000378757
- ENSP00000368032
- ENST00000378764
- ENSP00000368040
- FIP2
- GLC1E
- HIP7
- HYPL
- NRP
- NRP
- FIP2
- HIP7
- HYPL
- ALS12
- GLC1E
- TFIIIA-INTP
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
virus perturbation | 1 | ||
transcription factor perturbation | 0.98 | ||
disease perturbation | 0.95 | ||
kinase perturbation | 0.91 | ||
cellular component | 0.82 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1309.92 (req: < 5)
Gene RIFs: 132 (req: <= 3)
Antibodies: 320 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1309.92 (req: >= 5)
Gene RIFs: 132 (req: > 3)
Antibodies: 320 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 23
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (228)
AIMP1
Family: Enzyme
Novelty: 0.00743447
p_int: 0.999997342
p_ni: 0.000002658
Score: 0.19
Data Source: BioPlex,STRINGDB
RAB3IL1
Novelty: 0.0167537
p_int: 0.999985852
p_ni: 0.000014144
p_wrong: 4e-9
Score: 0.255
Data Source: BioPlex,STRINGDB
TNIP1
Novelty: 0.0147254
p_int: 0.999881254
p_ni: 0.0000575
p_wrong: 0.000061245
Score: 0.476
Data Source: BioPlex,STRINGDB
WDR20
Novelty: 0.03031804
p_int: 0.999522103
p_ni: 0.000143918
p_wrong: 0.000333979
Score: 0.189
Data Source: BioPlex,STRINGDB
TRIM16
Novelty: 0.03987217
p_int: 0.7718292
p_ni: 0.000034128
p_wrong: 0.228136672
Score: 0.403
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (11)
Reactome (9)
KEGG (1)
PathwayCommons (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Cell Cycle | ||||
Reactome | Cell Cycle, Mitotic | ||||
Reactome | G2/M Transition | ||||
Reactome | Membrane Trafficking | ||||
Reactome | Mitotic G2-G2/M phases | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Cell Cycle | ||||
Cell Cycle, Mitotic | ||||
G2/M Transition | ||||
Membrane Trafficking | ||||
Mitotic G2-G2/M phases | ||||
Viral Interactions (0)
Gene Ontology Terms (33)
Functions (7)
Components (10)
Processes (16)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Physical Interaction (IPI) | ParkinsonsUK-UCL | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (1)
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
2 | 1 | 0 | 1.6 | 82 | |||||
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
0 | 1.6 | 82 | |||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | optineurin | VGNC:4972 | 736417 | |||||
Macaque | optineurin | 574252 | ||||||
Mouse | MGI:1918898 | 71648 | ||||||
Rat | RGD:628886 | 246294 | ||||||
Dog | optineurin | VGNC:44136 | 478003 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | optineurin | |||||
Macaque | optineurin | |||||
Mouse | ||||||
Rat | ||||||
Dog | optineurin | |||||
Publication Statistics
PubMed Score 1309.92
PubMed score by year
PubTator Score 435.14
PubTator score by year
Related Publications
Text Mined References (181)
GeneRif Annotations (132)
Items per page:
0 of 0
PMID | Year | Title |
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