Tbio OPTN Optineurin

Protein Summary

Description

Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8 (PubMed:27534431). Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation (PubMed:27534431). Plays a role in the activation of innate immune response during viral infection. Mechanistically, recruits TBK1 at the Golgi apparatus, promoting its trans-phosphorylation after RLR or TLR3 stimulation (PubMed:27538435). In turn, activated TBK1 phosphorylates its downstream partner IRF3 to produce IFN-beta. Plays a neuroprotective role in the eye and optic nerve. May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin (HD). Mediates the interaction of Rab8 with the probable GTPase-activating protein TBC1D17 during Rab8-mediated endocytic trafficking, such as of transferrin receptor (TFRC/TfR); regulates Rab8 recruitment to tubules emanating from the endocytic recycling compartment. Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family; targets ubiquitin-coated bacteria (xenophagy), such as cytoplasmic Salmonella enterica, and appears to function in the same pathway as SQSTM1 and CALCOCO2/NDP52. (Microbial infection) May constitute a cellular target for adenovirus E3 14.7 and Bluetongue virus protein NS3 to inhibit innate immune response. This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q96CV9
• B3KP00
• D3DRS4
• D3DRS8
• Q5T672
• Q5T673
• Q5T674
• Q5T675
• Q7LDL9
• Q8N562
• Q9UET9
• Q9UEV4
• Q9Y218

Gene Name

• OPTN

Ensembl ID

• ENST00000263036
• ENSP00000263036
• ENSG00000123240
• ENST00000378747
• ENSP00000368021
• ENST00000378748
• ENSP00000368022
• ENST00000378752
• ENSP00000368027
• ENST00000378757
• ENSP00000368032
• ENST00000378764
• ENSP00000368040

Symbol

• FIP2
• GLC1E
• HIP7
• HYPL
• NRP
• NRP
• FIP2
• HIP7
• HYPL
• ALS12
• GLC1E
• TFIIIA-INTP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	1
transcription factor perturbation	0.98
disease perturbation	0.95
kinase perturbation	0.91
cellular component	0.82

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1309.92   (req: < 5)

Gene RIFs: 132   (req: <= 3)

Antibodies: 320   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1309.92   (req: >= 5)

Gene RIFs: 132   (req: > 3)

Antibodies: 320   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (228)

Explore Interacting Targets

1 – 10 of 228

• See Interactions on String-DB

STX12

Tbio

Novelty:  0.03836262

p_int:  0.999999986

p_ni:  6e-9

p_wrong:  8e-9

Data Source:  BioPlex

AIMP1

Tbio

Family:  Enzyme

Novelty:  0.00743447

p_int:  0.999997342

p_ni:  0.000002658

Score:  0.19

Data Source:  BioPlex,STRINGDB

RAB3IL1

Tbio

Novelty:  0.0167537

p_int:  0.999985852

p_ni:  0.000014144

p_wrong:  4e-9

Score:  0.255

Data Source:  BioPlex,STRINGDB

TNIP1

Tbio

Novelty:  0.0147254

p_int:  0.999881254

p_ni:  0.0000575

p_wrong:  0.000061245

Score:  0.476

Data Source:  BioPlex,STRINGDB

WDR20

Tbio

Novelty:  0.03031804

p_int:  0.999522103

p_ni:  0.000143918

p_wrong:  0.000333979

Score:  0.189

Data Source:  BioPlex,STRINGDB

ZMYM6

Tdark

Novelty:  0.4933879

p_int:  0.990652169

p_ni:  0.009347831

Data Source:  BioPlex

TRIM16

Tbio

Novelty:  0.03987217

p_int:  0.7718292

p_ni:  0.000034128

p_wrong:  0.228136672

Score:  0.403

Data Source:  BioPlex,STRINGDB

TBK1

Tchem

Family:  Kinase

Novelty:  0.00194753

Score:  0.995

Data Source:  STRINGDB

RAB8A

Tbio

Family:  Enzyme

Novelty:  0.00486694

Score:  0.985

Data Source:  Reactome,STRINGDB

MAP1LC3B

Tbio

Novelty:  0.00101276

Score:  0.983

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (11)

Reactome (9)

KEGG (1)

PathwayCommons (1)

Cell Cycle (R-HSA-1640170)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cell Cycle	597 targets	R-HSA-1640170
Reactome	Cell Cycle, Mitotic	495 targets	R-HSA-69278
Reactome	G2/M Transition	184 targets	R-HSA-69275
Reactome	Membrane Trafficking	612 targets	R-HSA-199991
Reactome	Mitotic G2-G2/M phases	186 targets	R-HSA-453274

Name	Explore in Pharos	Explore in Source
Cell Cycle	597 targets	R-HSA-1640170
Cell Cycle, Mitotic	495 targets	R-HSA-69278
G2/M Transition	184 targets	R-HSA-69275
Membrane Trafficking	612 targets	R-HSA-199991
Mitotic G2-G2/M phases	186 targets	R-HSA-453274

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (33)

Functions (7)

Components (10)

Processes (16)

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1 – 7 of 7

GO Term	Evidence	Assigned by
polyubiquitin modification-dependent protein binding	Inferred from Direct Assay (IDA)	UniProtKB
identical protein binding	Inferred from Physical Interaction (IPI)	IntAct
protein binding, bridging	Inferred from Physical Interaction (IPI)	ParkinsonsUK-UCL
protein C-terminus binding	Inferred from Physical Interaction (IPI)	UniProtKB
Rab GTPase binding	Inferred from Physical Interaction (IPI)	UniProtKB
K63-linked polyubiquitin modification-dependent protein binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations ()

No disease associations found

GWAS Traits (1)

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1 – 1 of 1

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
osteitis deformans	EFO_0004261	2	1	0	1.6	82

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
osteitis deformans	EFO_0004261	0	1.6	82

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
Amyotrophic lateral sclerosis
Autophagy
Coiled coil
Complete proteome
Cytoplasm
Cytoplasmic vesicle
Disease mutation
Endosome

GWAS Trait Find Similar Targets

No Header	No Header
osteitis deformans

MGI Phenotype Find Similar Targets

No Header	No Header
homeostasis/metabolism phenotype
mortality/aging

IDG Resources

No IDG generated resources found

Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	optineurin	VGNC:4972	736417
Macaque	optineurin		574252
Mouse	optineurin	MGI:1918898	71648
Rat	optineurin	RGD:628886	246294
Dog	optineurin	VGNC:44136	478003

Species	Name	OMA	EggNOG	Inparanoid
Chimp	optineurin
Macaque	optineurin
Mouse	optineurin
Rat	optineurin
Dog	optineurin

Publication Statistics

PubMed Score 1309.92

PubMed score by year

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PubTator Score 435.14

PubTator score by year

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Related Publications

Text Mined References (181)

GeneRif Annotations (132)

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PMID	Year	Title