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Tclin
OPRM1
Mu-type opioid receptor

Protein Summary
Description
Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone (PubMed:7905839, PubMed:7957926, PubMed:7891175, PubMed:12589820, PubMed:9689128). Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociation of the G-protein complex with the free GTP-bound G-protein alpha and the G-protein beta-gamma dimer activating downstream cellular effectors (PubMed:7905839). The agonist- and cell type-specific activity is predominantly coupled to pertussis toxin-sensitive G(i) and G(o) G alpha proteins, GNAI1, GNAI2, GNAI3 and GNAO1 isoforms Alpha-1 and Alpha-2, and to a lesser extent to pertussis toxin-insensitive G alpha proteins GNAZ and GNA15 (PubMed:12068084). They mediate an array of downstream cellular responses, includi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000229768
  • ENSP00000229768
  • ENSG00000112038
  • ENST00000330432
  • ENSP00000328264
  • ENST00000337049
  • ENSP00000338381
  • ENST00000414028
  • ENSP00000399359
  • ENST00000419506
  • ENSP00000403549
  • ENST00000428397
  • ENSP00000411903
  • ENST00000434900
  • ENSP00000394624
  • ENST00000435918
  • ENSP00000413752
  • ENST00000452687
  • ENSP00000410497
  • ENST00000518759
  • ENSP00000430260
  • ENST00000519083
  • ENSP00000431048
  • ENST00000520708
  • ENSP00000430876
  • ENST00000522236
  • ENSP00000429373
  • ENST00000522555
  • ENSP00000429719
  • ENST00000522739
  • ENSP00000428018
  • ENST00000524150
  • ENSP00000430575
  • ENST00000524163
  • ENSP00000430097

Symbol
  • MOR1
  • MOP
  • MOR
  • LMOR
  • MOR1
  • OPRM
  • M-OR-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug
1
molecular function
1
biological process
0.99
ligand (chemical)
0.99
kinase
0.96


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3424.4   (req: < 5)
Gene RIFs: 402   (req: <= 3)
Antibodies: 512   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3424.4   (req: >= 5)
Gene RIFs: 402   (req: > 3)
Antibodies: 512   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 48
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2600
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 42