Protein Summary
Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone (PubMed:7905839, PubMed:7957926, PubMed:7891175, PubMed:12589820, PubMed:9689128). Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociation of the G-protein complex with the free GTP-bound G-protein alpha and the G-protein beta-gamma dimer activating downstream cellular effectors (PubMed:7905839). The agonist- and cell type-specific activity is predominantly coupled to pertussis toxin-sensitive G(i) and G(o) G alpha proteins, GNAI1, GNAI2, GNAI3 and GNAO1 isoforms Alpha-1 and Alpha-2, and to a lesser extent to pertussis toxin-insensitive G alpha proteins GNAZ and GNA15 (PubMed:12068084). They mediate an array of downstream cellular responses, includi ...more
- ENST00000229768
- ENSP00000229768
- ENSG00000112038
- ENST00000330432
- ENSP00000328264
- ENST00000337049
- ENSP00000338381
- ENST00000414028
- ENSP00000399359
- ENST00000419506
- ENSP00000403549
- ENST00000428397
- ENSP00000411903
- ENST00000434900
- ENSP00000394624
- ENST00000435918
- ENSP00000413752
- ENST00000452687
- ENSP00000410497
- ENST00000518759
- ENSP00000430260
- ENST00000519083
- ENSP00000431048
- ENST00000520708
- ENSP00000430876
- ENST00000522236
- ENSP00000429373
- ENST00000522555
- ENSP00000429719
- ENST00000522739
- ENSP00000428018
- ENST00000524150
- ENSP00000430575
- ENST00000524163
- ENSP00000430097
- MOR1
- MOP
- MOR
- LMOR
- MOR1
- OPRM
- M-OR-1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
drug | 1 | ||
molecular function | 1 | ||
biological process | 0.99 | ||
ligand (chemical) | 0.99 | ||
kinase | 0.96 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2784.86 (req: < 5)
Gene RIFs: 402 (req: <= 3)
Antibodies: 512 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2784.86 (req: >= 5)
Gene RIFs: 402 (req: > 3)
Antibodies: 512 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 48
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 2476
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 42
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (42)
Active Ligands (2476)
Protein-Protein Interactions (456)
ZFYVE26
Novelty: 0.04897973
p_int: 0.999799451
p_ni: 0.000007509
p_wrong: 0.00019304
Score: 0.239
Data Source: BioPlex,STRINGDB
MMS22L
Novelty: 0.22570578
p_int: 0.9990965
p_ni: 0.000899655
p_wrong: 0.000003845
Data Source: BioPlex
LPCAT3
Family: Enzyme
Novelty: 0.00485213
p_int: 0.997624847
p_ni: 0.002373546
p_wrong: 0.000001607
Data Source: BioPlex
HTT
Novelty: 0.00034051
p_int: 0.996145315
p_ni: 0.003854685
Score: 0.219
Data Source: BioPlex,STRINGDB
MZT2B
Novelty: 0.69469786
p_int: 0.994954521
p_ni: 0.004100907
p_wrong: 0.000944572
Data Source: BioPlex
Nearest Tclin Targets
Pathways (28)
Reactome (18)
KEGG (3)
PathwayCommons (4)
WikiPathways (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Class A/1 (Rhodopsin-like receptors) | ||||
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | G alpha (i) signalling events | ||||
Reactome | G-protein activation | ||||
Reactome | GPCR downstream signalling | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Class A/1 (Rhodopsin-like receptors) | ||||
Cytokine Signaling in Immune system | ||||
G alpha (i) signalling events | ||||
G-protein activation | ||||
GPCR downstream signalling | ||||
Viral Interactions (0)
Gene Ontology Terms (65)
Functions (10)
Components (17)
Processes (38)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations (null)
GWAS Traits (9)
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
2 | 2 | 0 | 1.2 | 55.8 | |||||
diastolic blood pressure | 1 | 1 | 1 | 48.5 | |||||
IGF-1 measurement | 1 | 1 | 1 | 42.3 | |||||
body height | 1 | 1 | 1 | 39.6 | |||||
opioid use disorder | 1 | 1 | 1 | 36.9 | |||||
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
0 | 1.2 | 55.8 | |||||
diastolic blood pressure | 1 | 48.5 | |||||
IGF-1 measurement | 1 | 42.3 | |||||
body height | 1 | 39.6 | |||||
opioid use disorder | 1 | 36.9 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | opioid receptor mu 1 | VGNC:9593 | 472165 | |||||
Macaque | opioid receptor mu 1 | 574141 | ||||||
Mouse | MGI:97441 | 18390 | ||||||
Rat | RGD:3234 | 25601 | ||||||
Horse | opioid receptor mu 1 | VGNC:21045 | 100060029 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | opioid receptor mu 1 | |||||
Macaque | opioid receptor mu 1 | |||||
Mouse | ||||||
Rat | ||||||
Horse | opioid receptor mu 1 | |||||
Publication Statistics
PubMed Score 2784.86
PubMed score by year
PubTator Score 1250.74
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (498)
GeneRif Annotations (402)
Items per page:
0 of 0
PMID | Year | Title |
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