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Tclin
OPRD1
Delta-type opioid receptor

Protein Summary
Description
G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000234961
  • ENSP00000234961
  • ENSG00000116329

Symbol
  • OPRD
  • DOP
  • DOR
  • DOR1
  • OPRD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug
0.98
ligand (chemical)
0.98
biological process
0.89
gene perturbation
0.76
chemical
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 124.14   (req: < 5)
Gene RIFs: 77   (req: <= 3)
Antibodies: 380   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 124.14   (req: >= 5)
Gene RIFs: 77   (req: > 3)
Antibodies: 380   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2078
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 16
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (16)
fentanyl
Rendered image for fentanyl
nalfurafine
Rendered image for nalfurafine
alvimopan
Rendered image for alvimopan
levorphanol
Rendered image for levorphanol
pethidine
Rendered image for pethidine
naltrexone
Rendered image for naltrexone
naloxone
Rendered image for naloxone
butorphanol
Rendered image for butorphanol
hydromorphone
Rendered image for hydromorphone
morphine
Rendered image for morphine
Protein-Protein Interactions (349)
PDYN
Tbio
Novelty:  0.00039564
Score:  0.992
Data Source:  STRINGDB
POMC
Tbio
Novelty:  0.00002436
Score:  0.986
Data Source:  STRINGDB
CNR1
Tclin
Family:  GPCR
Novelty:  0.00060063
Score:  0.983
Data Source:  STRINGDB
PNOC
Tbio
Novelty:  0.00132014
Score:  0.977
Data Source:  STRINGDB
PENK
Tbio
Novelty:  0.00074167
Score:  0.976
Data Source:  STRINGDB
CNR2
Tchem
Family:  GPCR
Novelty:  0.00215391
Score:  0.965
Data Source:  STRINGDB
NPY
Tbio
Novelty:  0.00012637
Score:  0.956
Data Source:  STRINGDB
GABBR1
Tclin
Family:  GPCR
Novelty:  0.00086493
Score:  0.956
Data Source:  STRINGDB
KNG1
Tbio
Novelty:  0.00007684
Score:  0.956
Data Source:  STRINGDB
SST
Tbio
Novelty:  0.00005944
Score:  0.952
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (21)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
Cytokine Signaling in Immune system
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
Cytokine Signaling in Immune system
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (37)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
3
3
95
mean reticulocyte volume
1
2
2
71.1
platelet count
2
2
2
53.1
IGF-1 measurement
1
1
1
42.3
mean corpuscular volume
1
1
1
39.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
95
mean reticulocyte volume
2
71.1
platelet count
2
53.1
IGF-1 measurement
1
42.3
mean corpuscular volume
1
39.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
opioid receptor delta 1
VGNC:9397
456688
Macaque
opioid receptor delta 1
717256
Mouse
MGI:97438
18386
Rat
RGD:3233
24613
Dog
opioid receptor delta 1
VGNC:44132
487329
Species
Name
OMA
EggNOG
Inparanoid
Chimp
opioid receptor delta 1
Macaque
opioid receptor delta 1
Mouse
Rat
Dog
opioid receptor delta 1
Publication Statistics
PubMed Score 124.14
PubMed score by year
PubTator Score 96.70
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title