Tbio OPN5 Opsin-5

Protein Summary

Description

Opsins are members of the guanine nucleotide-binding protein (G protein)-coupled receptor superfamily. This opsin gene is expressed in the eye, brain, testes, and spinal cord. This gene belongs to the seven-exon subfamily of mammalian opsin genes that includes peropsin (RRH) and retinal G protein coupled receptor (RGR). Like these other seven-exon opsin genes, this family member may encode a protein with photoisomerase activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]

Uniprot Accession IDs

• Q6U736
• A0AV33
• Q5T5B9
• Q5T886
• Q7Z603
• Q86SL5

Gene Name

• OPN5

Ensembl ID

• ENST00000371211
• ENSP00000360255
• ENSG00000124818
• ENST00000638973
• ENSP00000491960

Symbol

• GPR136
• PGR12
• TMEM13
• PGR12
• GPR136
• GRP136
• TMEM13

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
microRNA	0.62
protein domain	0.58
tissue	0.57
molecular function	0.56
cell line	0.52

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / Opsin-5

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Opsin-5

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.86   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 208   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.86   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 208   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0