Protein Summary
Photoreceptor required for regulation of circadian rhythm. Contributes to pupillar reflex and other non-image forming responses to light. May be able to isomerize covalently bound all-trans retinal back to 11-cis retinal (By similarity). Opsins are members of the guanine nucleotide-binding protein (G protein)-coupled receptor superfamily. This gene encodes a photoreceptive opsin protein that is expressed within the ganglion and amacrine cell layers of the retina. In mouse, retinal ganglion cell axons expressing this gene projected to the suprachiasmatic nucleus and other brain nuclei involved in circadian photoentrainment. In mouse, this protein is coupled to a transient receptor potential (TRP) ion channel through a G protein signaling pathway and produces a physiologic light response via membrane depolarization and increased intracellular calcium. The protein functions as a sensory photopigment and may also have photoisomerase activity. Experiments with knockout mice indicate that th ...more
- ENST00000241891
- ENSP00000241891
- ENSG00000122375
- ENST00000372071
- ENSP00000361141
- MOP
- MOP
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.6 | ||
protein domain | 0.58 | ||
transcription factor | 0.57 | ||
cell line | 0.53 | ||
tissue | 0.52 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1066.36 (req: < 5)
Gene RIFs: 25 (req: <= 3)
Antibodies: 78 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1066.36 (req: >= 5)
Gene RIFs: 25 (req: > 3)
Antibodies: 78 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (246)
STX12
Novelty: 0.03836262
p_int: 0.920015937
p_ni: 0.079984057
p_wrong: 6e-9
Score: 0.367
Data Source: BioPlex,STRINGDB
NDFIP1
Novelty: 0.04496467
p_int: 0.876943874
p_ni: 0.123056126
Score: 0.242
Data Source: BioPlex,STRINGDB
STX10
Novelty: 0.05193552
p_int: 0.764082392
p_ni: 0.234927769
p_wrong: 0.000989839
Score: 0.827
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (9)
Reactome (7)
WikiPathways (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Class A/1 (Rhodopsin-like receptors) | ||||
Reactome | G alpha (q) signalling events | ||||
Reactome | GPCR downstream signalling | ||||
Reactome | GPCR ligand binding | ||||
Reactome | Opsins | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Class A/1 (Rhodopsin-like receptors) | ||||
G alpha (q) signalling events | ||||
GPCR downstream signalling | ||||
GPCR ligand binding | ||||
Opsins | ||||
Viral Interactions (0)
Gene Ontology Terms (12)
Functions (2)
Components (3)
Processes (7)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Disease Associations ()
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
heel bone mineral density | 1 | 1 | 1 | 33.1 | |||||
electrocardiography | 1 | 1 | 2 | 15.8 | |||||
apolipoprotein A 1 measurement | 1 | 1 | 1 | 6.1 | |||||
high density lipoprotein cholesterol measurement | 1 | 1 | 1 | 1.7 | |||||
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
heel bone mineral density | 1 | 33.1 | |||||
electrocardiography | 2 | 15.8 | |||||
apolipoprotein A 1 measurement | 1 | 6.1 | |||||
high density lipoprotein cholesterol measurement | 1 | 1.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | opsin 4 | VGNC:14323 | 107966782 | |||||
Macaque | opsin 4 | 699800 | ||||||
Mouse | MGI:1353425 | 30044 | ||||||
Rat | RGD:621701 | 192223 | ||||||
Dog | opsin 4 | VGNC:51909 | 611027 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | opsin 4 | |||||
Macaque | opsin 4 | |||||
Mouse | ||||||
Rat | ||||||
Dog | opsin 4 | |||||
Publication Statistics
PubMed Score 1066.36
PubMed score by year
PubTator Score 351.67
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (40)
GeneRif Annotations (25)
Items per page:
0 of 0
PMID | Year | Title |
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