Tbio OPN3 Opsin-3

Protein Summary

Description

May play a role in encephalic photoreception. Opsins are members of the guanine nucleotide-binding protein (G protein)-coupled receptor superfamily. In addition to the visual opsins, mammals possess several photoreceptive non-visual opsins that are expressed in extraocular tissues. This gene, opsin 3, is strongly expressed in brain and testis and weakly expressed in liver, placenta, heart, lung, skeletal muscle, kidney, and pancreas. The gene may also be expressed in the retina. The protein has the canonical features of a photoreceptive opsin protein. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9H1Y3
• Q8IX08
• Q9Y344

Gene Name

• OPN3

Ensembl ID

• ENST00000366554
• ENSP00000355512
• ENSG00000054277

Symbol

• ECPN
• ECPN
• PPP1R116

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.96
PubMedID	0.78
transcription factor perturbation	0.68
transcription factor binding site profile	0.64
histone modification site profile	0.61

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / Opsin-3

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Opsin-3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.58   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 220   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.58   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 220   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (58)

Explore Interacting Targets

1 – 10 of 58

• See Interactions on String-DB

EIF2B3

Tbio

Novelty:  0.04963646

p_int:  0.987707536

p_ni:  0.012292464

Score:  0.787

Data Source:  BioPlex,STRINGDB

EIF2B2

Tbio

Novelty:  0.03253919

p_int:  0.978287073

p_ni:  0.021712927

Score:  0.816

Data Source:  BioPlex,STRINGDB

EIF2B4

Tbio

Novelty:  0.05080792

p_int:  0.972365549

p_ni:  0.027634451

Score:  0.207

Data Source:  BioPlex,STRINGDB

EIF2B5

Tbio

Novelty:  0.0102209

p_int:  0.823399672

p_ni:  0.176600328

Score:  0.702

Data Source:  BioPlex,STRINGDB

GNAT2

Tbio

Novelty:  0.01683655

Score:  0.935

Data Source:  STRINGDB

RGR

Tbio

Family:  GPCR

Novelty:  0.03133861

Score:  0.927

Data Source:  STRINGDB

OPN5

Tbio

Family:  GPCR

Novelty:  0.02890415

Score:  0.925

Data Source:  STRINGDB

GNAT1

Tbio

Novelty:  0.03042002

Score:  0.925

Data Source:  STRINGDB

GNB5

Tbio

Novelty:  0.0067714

Score:  0.924

Data Source:  STRINGDB

GNB1

Tbio

Novelty:  0.02477955

Score:  0.916

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (9)

Reactome (7)

WikiPathways (2)

Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Class A/1 (Rhodopsin-like receptors)	323 targets	R-HSA-373076
Reactome	G alpha (i) signalling events	408 targets	R-HSA-418594
Reactome	GPCR downstream signalling	1152 targets	R-HSA-388396
Reactome	GPCR ligand binding	460 targets	R-HSA-500792
Reactome	Opsins	9 targets	R-HSA-419771

Name	Explore in Pharos	Explore in Source
Class A/1 (Rhodopsin-like receptors)	323 targets	R-HSA-373076
G alpha (i) signalling events	408 targets	R-HSA-418594
GPCR downstream signalling	1152 targets	R-HSA-388396
GPCR ligand binding	460 targets	R-HSA-500792
Opsins	9 targets	R-HSA-419771

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (12)

Functions (3)

Components (3)

Processes (6)

Find Similar Targets

Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
G protein-coupled photoreceptor activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
G protein-coupled receptor activity	Traceable Author Statement (TAS)	ProtInc
photoreceptor activity	Non-traceable Author Statement (NAS)	UniProtKB

Disease Associations ()

No disease associations found

GWAS Traits (2)

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1 – 2 of 2

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mathematical ability	EFO_0004875	2	2	2		72.1
self reported educational attainment	EFO_0004784	1	1	1		62.1

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 2 of 2

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mathematical ability	EFO_0004875	2		72.1
self reported educational attainment	EFO_0004784	1		62.1

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UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Chromophore
Complete proteome
Disulfide bond
G-protein coupled receptor
Glycoprotein
Lipoprotein
Membrane
Palmitate
Photoreceptor protein

GWAS Trait Find Similar Targets

No Header	No Header
mathematical ability
self reported educational attainment

IDG Resources

No IDG generated resources found

Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	opsin 3	VGNC:6924	457854
Macaque	opsin 3		707436
Mouse	opsin 3	MGI:1338022	13603
Rat	opsin 3	RGD:1594385	498289
Dog	opsin 3	VGNC:44130	102155438

Species	Name	OMA	EggNOG	Inparanoid
Chimp	opsin 3
Macaque	opsin 3
Mouse	opsin 3
Rat	opsin 3
Dog	opsin 3

Publication Statistics

PubMed Score 65.58

PubMed score by year

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PubTator Score 12.00

PubTator score by year

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Patents

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Related Publications

Text Mined References (15)

GeneRif Annotations (7)

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10

0 of 0

PMID	Year	Title