Protein Summary
May play a role in encephalic photoreception. Opsins are members of the guanine nucleotide-binding protein (G protein)-coupled receptor superfamily. In addition to the visual opsins, mammals possess several photoreceptive non-visual opsins that are expressed in extraocular tissues. This gene, opsin 3, is strongly expressed in brain and testis and weakly expressed in liver, placenta, heart, lung, skeletal muscle, kidney, and pancreas. The gene may also be expressed in the retina. The protein has the canonical features of a photoreceptive opsin protein. [provided by RefSeq, Jul 2008]
- ENST00000366554
- ENSP00000355512
- ENSG00000054277
- ECPN
- ECPN
- PPP1R116
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
gene perturbation | 0.96 | ||
PubMedID | 0.78 | ||
transcription factor perturbation | 0.68 | ||
transcription factor binding site profile | 0.64 | ||
histone modification site profile | 0.61 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 65.58 (req: < 5)
Gene RIFs: 7 (req: <= 3)
Antibodies: 220 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 65.58 (req: >= 5)
Gene RIFs: 7 (req: > 3)
Antibodies: 220 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (58)
EIF2B3
Novelty: 0.04963646
p_int: 0.987707536
p_ni: 0.012292464
Score: 0.787
Data Source: BioPlex,STRINGDB
EIF2B2
Novelty: 0.03253919
p_int: 0.978287073
p_ni: 0.021712927
Score: 0.816
Data Source: BioPlex,STRINGDB
EIF2B4
Novelty: 0.05080792
p_int: 0.972365549
p_ni: 0.027634451
Score: 0.207
Data Source: BioPlex,STRINGDB
EIF2B5
Novelty: 0.0102209
p_int: 0.823399672
p_ni: 0.176600328
Score: 0.702
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (9)
Reactome (7)
WikiPathways (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Class A/1 (Rhodopsin-like receptors) | ||||
Reactome | G alpha (i) signalling events | ||||
Reactome | GPCR downstream signalling | ||||
Reactome | GPCR ligand binding | ||||
Reactome | Opsins | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Class A/1 (Rhodopsin-like receptors) | ||||
G alpha (i) signalling events | ||||
GPCR downstream signalling | ||||
GPCR ligand binding | ||||
Opsins | ||||
Viral Interactions (0)
Gene Ontology Terms (12)
Functions (3)
Components (3)
Processes (6)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | ProtInc | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Disease Associations ()
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
mathematical ability | 2 | 2 | 2 | 72.1 | |||||
self reported educational attainment | 1 | 1 | 1 | 62.1 | |||||
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
mathematical ability | 2 | 72.1 | |||||
self reported educational attainment | 1 | 62.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | opsin 3 | VGNC:6924 | 457854 | |||||
Macaque | opsin 3 | 707436 | ||||||
Mouse | MGI:1338022 | 13603 | ||||||
Rat | RGD:1594385 | 498289 | ||||||
Dog | opsin 3 | VGNC:44130 | 102155438 | |||||
Publication Statistics
PubMed Score 65.58
PubMed score by year
PubTator Score 12.00
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (15)
GeneRif Annotations (7)
Items per page:
0 of 0
PMID | Year | Title |
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