Protein Summary
Catalyzes the cleavage of 5-oxo-L-proline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate. The protein encoded by this gene acts as a homodimer, using ATP hydrolysis to catalyze the conversion of 5-oxo-L-proline to L-glutamate. Defects in this gene are a cause of 5-oxoprolinase deficiency (OPLAHD). [provided by RefSeq, Jun 2012]
- ENST00000618853
- ENSP00000480476
- ENSG00000178814
- OPLA
- OPLAHD
- 5-Opase
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.86 | ||
co-expressed gene | 0.69 | ||
histone modification site profile | 0.69 | ||
PubMedID | 0.68 | ||
cell type or tissue | 0.61 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 28.79 (req: < 5)
Gene RIFs: 3 (req: <= 3)
Antibodies: 63 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 28.79 (req: >= 5)
Gene RIFs: 3 (req: > 3)
Antibodies: 63 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (42)
Nearest Tclin Targets (2)
Upstream (1)
Downstream (1)
1 – 1 of 1
Pathways (14)
Reactome (9)
KEGG (2)
PathwayCommons (1)
WikiPathways (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Biological oxidations | ||||
Reactome | Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) | ||||
Reactome | Disease | ||||
Reactome | Diseases of metabolism | ||||
Reactome | Glutathione conjugation | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Biological oxidations | ||||
Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) | ||||
Disease | ||||
Diseases of metabolism | ||||
Glutathione conjugation | ||||
Viral Interactions (0)
Gene Ontology Terms (5)
Functions (2)
Components (1)
Processes (2)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (28)
Items per page:
1 – 5 of 28
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
low density lipoprotein cholesterol measurement | 8 | 7 | 10 | 96.4 | |||||
mean corpuscular volume | 2 | 2 | 2 | 90.4 | |||||
blood metabolite measurement | 1 | 2 | 2 | 89.7 | |||||
total cholesterol measurement | 3 | 3 | 3 | 87.9 | |||||
apolipoprotein B measurement | 2 | 2 | 2 | 87.4 | |||||
Items per page:
1 – 5 of 28
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
low density lipoprotein cholesterol measurement | 10 | 96.4 | |||||
mean corpuscular volume | 2 | 90.4 | |||||
blood metabolite measurement | 2 | 89.7 | |||||
total cholesterol measurement | 3 | 87.9 | |||||
apolipoprotein B measurement | 2 | 87.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Mouse | MGI:1922725 | 75475 | ||||||
Rat | RGD:620956 | 116684 | ||||||
Dog | 5-oxoprolinase, ATP-hydrolysing | VGNC:49607 | 482085 | |||||
Cow | 5-oxoprolinase, ATP-hydrolysing | VGNC:53869 | 408006 | |||||
Pig | 5-oxoprolinase, ATP-hydrolysing | 100515137 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Mouse | ||||||
Rat | ||||||
Dog | 5-oxoprolinase, ATP-hydrolysing | |||||
Cow | 5-oxoprolinase, ATP-hydrolysing | |||||
Pig | 5-oxoprolinase, ATP-hydrolysing | |||||
Publication Statistics
PubMed Score 28.79
PubMed score by year
PubTator Score 33.26
PubTator score by year
Related Publications
Text Mined References (11)
GeneRif Annotations (3)
Items per page:
0 of 0
PMID | Year | Title |
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