Tbio OPLAH 5-oxoprolinase

Protein Summary

Description

Catalyzes the cleavage of 5-oxo-L-proline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate. The protein encoded by this gene acts as a homodimer, using ATP hydrolysis to catalyze the conversion of 5-oxo-L-proline to L-glutamate. Defects in this gene are a cause of 5-oxoprolinase deficiency (OPLAHD). [provided by RefSeq, Jun 2012]

Uniprot Accession IDs

• O14841
• A5PKY8
• Q75W65
• Q9Y4Q0

Gene Name

• OPLAH

Ensembl ID

• ENST00000618853
• ENSP00000480476
• ENSG00000178814

Symbol

• OPLA
• OPLAHD
• 5-Opase

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.86
co-expressed gene	0.69
histone modification site profile	0.69
PubMedID	0.68
cell type or tissue	0.61

Protein Classes

PANTHER Classes

Protein / Hydrolase / 5-oxoprolinase

DTO Classes

Protein / Enzyme / Hydrolase / 5-oxoprolinase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.84   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 63   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.84   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 63   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0