Protein Summary
Catalyzes the cleavage of 5-oxo-L-proline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate. The protein encoded by this gene acts as a homodimer, using ATP hydrolysis to catalyze the conversion of 5-oxo-L-proline to L-glutamate. Defects in this gene are a cause of 5-oxoprolinase deficiency (OPLAHD). [provided by RefSeq, Jun 2012]
- ENST00000618853
- ENSP00000480476
- ENSG00000178814
- OPLA
- OPLAHD
- 5-Opase
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
molecular function | 0.86 | ||
co-expressed gene | 0.69 | ||
histone modification site profile | 0.69 | ||
PubMedID | 0.68 | ||
cell type or tissue | 0.61 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 28.79 (req: < 5)
Gene RIFs: 3 (req: <= 3)
Antibodies: 63 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 28.79 (req: >= 5)
Gene RIFs: 3 (req: > 3)
Antibodies: 63 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

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Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (42)
Nearest Tclin Targets (2)
Upstream (1)
Downstream (1)
1 – 1 of 1
Pathways (14)
Reactome (9)
KEGG (2)
PathwayCommons (1)
WikiPathways (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Biological oxidations | ||||
Reactome | Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) | ||||
Reactome | Disease | ||||
Reactome | Diseases of metabolism | ||||
Reactome | Glutathione conjugation | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Biological oxidations | ||||
Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) | ||||
Disease | ||||
Diseases of metabolism | ||||
Glutathione conjugation | ||||
Viral Interactions (0)
Gene Ontology Terms (5)
Functions (2)
Components (1)
Processes (2)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (28)
Items per page:
1 – 5 of 28
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
low density lipoprotein cholesterol measurement | 8 | 7 | 10 | 96.4 | |||||
mean corpuscular volume | 2 | 2 | 2 | 90.4 | |||||
blood metabolite measurement | 1 | 2 | 2 | 89.7 | |||||
total cholesterol measurement | 3 | 3 | 3 | 87.9 | |||||
apolipoprotein B measurement | 2 | 2 | 2 | 87.4 | |||||
Items per page:
1 – 5 of 28
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
low density lipoprotein cholesterol measurement | 10 | 96.4 | |||||
mean corpuscular volume | 2 | 90.4 | |||||
blood metabolite measurement | 2 | 89.7 | |||||
total cholesterol measurement | 3 | 87.9 | |||||
apolipoprotein B measurement | 2 | 87.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Mouse | MGI:1922725 | 75475 | ||||||
Rat | RGD:620956 | 116684 | ||||||
Dog | 5-oxoprolinase, ATP-hydrolysing | VGNC:49607 | 482085 | |||||
Cow | 5-oxoprolinase, ATP-hydrolysing | VGNC:53869 | 408006 | |||||
Pig | 5-oxoprolinase, ATP-hydrolysing | 100515137 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Mouse | ||||||
Rat | ||||||
Dog | 5-oxoprolinase, ATP-hydrolysing | |||||
Cow | 5-oxoprolinase, ATP-hydrolysing | |||||
Pig | 5-oxoprolinase, ATP-hydrolysing | |||||
Publication Statistics
PubMed Score 28.79
PubMed score by year
PubTator Score 33.26
PubTator score by year
Related Publications
Text Mined References (11)
GeneRif Annotations (3)
Items per page:
0 of 0
PMID | Year | Title |
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