Pharos : Target Details

Tdark

Protein Summary

Uniprot Accession IDs

Gene Name

OPALIN

Ensembl ID

ENST00000371172
ENSP00000360214
ENSG00000197430
ENST00000393871
ENSP00000377449
ENST00000419479
ENSP00000398025
ENST00000611913
ENSP00000484599

Symbol

HTMP10
TMEM10
TMP10
HTMP10
TMEM10

Illumination Graph

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.93

microRNA	0.58

tissue	0.57

cellular component	0.54

cell line	0.51

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.75 (req: < 5)

View Publications

Gene RIFs: 1 (req: <= 3)

View Gene RIFs

Antibodies: 36 (req: <= 50)

View Antibodies

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.75 (req: >= 5)

Gene RIFs: 1 (req: > 3)

Antibodies: 36 (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Expression Data (0 Tissues)

No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

View Data

Go To Tool

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Go To Tool

Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (214)

Explore Interacting Targets

1 – 10 of 214

See Interactions on String-DB

ATP2B3

Tbio

Family: Transporter

Novelty: 0.00901493

p_int: 0.999990096

p_ni: 0.000009904

Score: 0.531

Data Source: BioPlex,STRINGDB

UTP20

Tbio

Novelty: 0.09170451

p_int: 0.999972505

p_ni: 0.000027494

p_wrong: 1e-9

Data Source: BioPlex

SMAD5

Tbio

Family: TF

Novelty: 0.00405952

p_int: 0.999966372

p_ni: 0.000030457

p_wrong: 0.000003171

Data Source: BioPlex

ATP2B4

Tbio

Family: Transporter

Novelty: 0.00560356

p_int: 0.999948669

p_ni: 0.000051329

p_wrong: 2e-9

Data Source: BioPlex

NF1

Tbio

Novelty: 0.00019092

p_int: 0.99993708

p_ni: 0.00006292

Data Source: BioPlex

RTTN

Tbio

Novelty: 0.04524944

p_int: 0.999921894

p_ni: 0.000002525

p_wrong: 0.000075581

Data Source: BioPlex

BTAF1

Tbio

Novelty: 0.01586704

p_int: 0.999895436

p_ni: 0.000104564

Data Source: BioPlex

ATP2B2

Tbio

Family: Transporter

Novelty: 0.007782

p_int: 0.999877492

p_ni: 0.000122508

Score: 0.531

Data Source: BioPlex,STRINGDB

ATR

Tchem

Family: Kinase

Novelty: 0.00196978

p_int: 0.999867212

p_ni: 0.000132788

Data Source: BioPlex

THADA

Tbio

Novelty: 0.06983966

p_int: 0.999825423

p_ni: 0.000174577

Data Source: BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (4)

Components (4)

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Items per page:

1 – 4 of 4

GO Term	Evidence	Assigned by
Golgi apparatus	Inferred from Direct Assay (IDA)	LIFEdb

cell-cell contact zone	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

plasma membrane	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

integral component of membrane	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations ()

No disease associations found

GWAS Traits (2)

Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 2 of 2

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Evidence (Mean Rank Score)
mean corpuscular volume	EFO_0004526	1	1	1	46.1

aging	GO_0007568	1	1	1	24.5

Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

1 – 2 of 2

GWAS Trait	EFO ID	Beta Count	Evidence (Mean Rank Score)
mean corpuscular volume	EFO_0004526	1	46.1

aging	GO_0007568	1	24.5

Beta Count

Odds Ratio

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UniProt Keyword

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No Header	No Header
Alternative splicing

Cell membrane

Complete proteome

Glycoprotein

Membrane

Reference proteome

Transmembrane

Transmembrane helix

GWAS Trait

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IDG Resources

No IDG generated resources found

Orthologs (8)

1 – 5 of 8

Species	Name	Source ID	Gene ID
Chimp	oligodendrocytic myelin paranodal and inner loop protein	VGNC:5587	450643

Macaque	oligodendrocytic myelin paranodal and inner loop protein		704725

Mouse	oligodendrocytic myelin paranodal and inner loop protein	MGI:2657025	226115

Rat	oligodendrocytic myelin paranodal and inner loop protein	RGD:1307776	361757

Dog	oligodendrocytic myelin paranodal and inner loop protein	VGNC:44127	608634

Species	Name	OMA	EggNOG	Inparanoid
Chimp	oligodendrocytic myelin paranodal and inner loop protein

Macaque	oligodendrocytic myelin paranodal and inner loop protein

Mouse	oligodendrocytic myelin paranodal and inner loop protein

Rat	oligodendrocytic myelin paranodal and inner loop protein

Dog	oligodendrocytic myelin paranodal and inner loop protein

Publication Statistics

PubMed Score 14.75

PubMed score by year

PubTator Score 11.60

PubTator score by year

Related Publications

Text Mined References (13)

GeneRif Annotations (1)

Items per page:

0 of 0

PMID	Year	Title