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Tbio
OLIG2
Oligodendrocyte transcription factor 2

Protein Summary
Description
Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Functions together with ZNF488 to promote oligodendrocyte differentiation. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development. This gene encodes a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. The protein is an essential regulator of ventral neuroectodermal progenitor cell fate. The gene is involved in a chromosomal translocation t(14;21)(q11.2;q22) associated with T-cell acute lymphoblastic leukemia. Its chromosomal location is within a region of chromosome 21 which has been suggested to play a role in learning deficits associated with Down syndrome. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000333337
  • ENSP00000331040
  • ENSG00000205927
  • ENST00000382357
  • ENSP00000371794

Symbol
  • BHLHB1
  • BHLHE19
  • PRKCBP2
  • RACK17
  • BHLHB1
  • OLIGO2
  • RACK17
  • PRKCBP2
  • bHLHe19
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.8
PubMedID
0.71
gene perturbation
0.59
transcription factor binding site profile
0.59
cellular component
0.56


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 714.77   (req: < 5)
Gene RIFs: 51   (req: <= 3)
Antibodies: 438   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 714.77   (req: >= 5)
Gene RIFs: 51   (req: > 3)
Antibodies: 438   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (188)
NKX2-2
Tbio
Family:  TF
Novelty:  0.00608835
Score:  0.954
Data Source:  STRINGDB
SOX10
Tbio
Family:  TF
Novelty:  0.00130552
Score:  0.937
Data Source:  STRINGDB
GFAP
Tbio
Novelty:  0.00020932
Score:  0.899
Data Source:  STRINGDB
PAX6
Tbio
Family:  TF
Novelty:  0.00064695
Score:  0.893
Data Source:  STRINGDB
SHH
Tchem
Novelty:  0.00028347
Score:  0.861
Data Source:  STRINGDB
ASCL1
Tbio
Family:  TF
Novelty:  0.00274239
Score:  0.848
Data Source:  STRINGDB
MBP
Tbio
Novelty:  0.00016333
Score:  0.842
Data Source:  STRINGDB
NES
Tbio
Novelty:  0.00035379
Score:  0.814
Data Source:  STRINGDB
NKX6-1
Tbio
Family:  TF
Novelty:  0.00776559
Score:  0.81
Data Source:  STRINGDB
ID2
Tbio
Family:  TF
Novelty:  0.00256364
Score:  0.804
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (15)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
3
4
90.9
eosinophil percentage of leukocytes
2
3
3
89
cortical surface area measurement
1
1
0
8.8
42.3
sum of eosinophil and basophil counts
1
1
1
39.6
alcohol consumption measurement
2
2
2
37.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
4
90.9
eosinophil percentage of leukocytes
3
89
cortical surface area measurement
0
8.8
42.3
sum of eosinophil and basophil counts
1
39.6
alcohol consumption measurement
2
37.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
oligodendrocyte transcription factor 2
700098
Mouse
MGI:1355331
50913
Rat
RGD:1307098
304103
Dog
oligodendrocyte transcription factor 2
VGNC:44118
100856424
Opossum
oligodendrocyte transcription factor 2
100026878
Species
Name
OMA
EggNOG
Inparanoid
Macaque
oligodendrocyte transcription factor 2
Mouse
Rat
Dog
oligodendrocyte transcription factor 2
Opossum
oligodendrocyte transcription factor 2
Publication Statistics
PubMed Score 714.77
PubMed score by year
PubTator Score 275.87
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title