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Tbio
OLFML3
Olfactomedin-like protein 3

Protein Summary
Description
Secreted scaffold protein that plays an essential role in dorsoventral patterning during early development. Stabilizes axial formation by restricting chordin (CHRD) activity on the dorsal side. Acts by facilitating the association between the tolloid proteases and their substrate chordin (CHRD), leading to enhance chordin (CHRD) degradation (By similarity). May have matrix-related function involved in placental and embryonic development, or play a similar role in other physiological processes. This gene encodes a member of the olfactomedin-like gene family which also includes genes encoding noelin, tiarin, myocilin, amassin, optimedin, photomedin, and latrophilin. The encoded protein is a secreted extracellular matrix glycoprotein with a C-terminal olfactomedin domain that facilitates protein-protein interactions, cell adhesion, and intercellular interactions. It serves as both a scaffold protein that recruits bone morphogenetic protein 1 to its substrate chordin, and as a vascular tis ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000320334
  • ENSP00000322273
  • ENSG00000116774
  • ENST00000369551
  • ENSP00000358564

Symbol
  • OLF44
  • HNOEL-iso
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.68
gene perturbation
0.62
tissue sample
0.62
disease
0.61
kinase perturbation
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.07   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 70   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.07   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 70   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (37)
MAP7D2
Tdark
Novelty:  0.70744439
p_int:  0.830685315
p_ni:  0.169314685
Score:  0.282
Data Source:  BioPlex,STRINGDB
TMEM119
Tbio
Novelty:  0.02762151
Score:  0.71
Data Source:  STRINGDB
CHRD
Tbio
Novelty:  0.00347659
Score:  0.678
Data Source:  STRINGDB
PRSS16
Tbio
Family:  Enzyme
Novelty:  0.03540615
Score:  0.673
Data Source:  STRINGDB
BMP1
Tchem
Novelty:  0.00299518
Score:  0.604
Data Source:  STRINGDB
COL1A2
Tbio
Novelty:  0.00048334
Score:  0.599
Data Source:  STRINGDB
GPR34
Tchem
Family:  GPCR
Novelty:  0.03810628
Score:  0.555
Data Source:  STRINGDB
FLRT3
Tbio
Novelty:  0.05467656
Score:  0.555
Data Source:  STRINGDB
COL1A1
Tbio
Novelty:  0.00063584
Score:  0.543
Data Source:  STRINGDB
P2RY12
Tclin
Family:  GPCR
Novelty:  0.00035406
Score:  0.515
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
autoimmune thyroid disease
1
1
0
1.9
49.5
1
1
0
1.9
49.5
1
1
1
39.6
heel bone mineral density
1
1
1
33.1
2
1
0
1.1
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
autoimmune thyroid disease
0
1.9
49.5
0
1.9
49.5
1
39.6
heel bone mineral density
1
33.1
0
1.1
31.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
olfactomedin like 3
VGNC:1427
457963
Macaque
olfactomedin like 3
707969
Mouse
MGI:1914877
99543
Rat
RGD:1311106
310743
Dog
olfactomedin like 3
VGNC:44117
483126
Species
Name
OMA
EggNOG
Inparanoid
Chimp
olfactomedin like 3
Macaque
olfactomedin like 3
Mouse
Rat
Dog
olfactomedin like 3
Publication Statistics
PubMed Score 13.07
PubMed score by year
PubTator Score 6.24
PubTator score by year
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Related Publications
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PMID
Year
Title