Tbio OLAH S-acyl fatty acid synthase thioesterase, medium chain

Protein Summary

Description

Contributes to the release of free fatty acids from fatty acid synthase (FASN). Has broad substrate specificity, giving rise to a range of free fatty acids with chain lengths between 10 and 16 carbon atoms (C10 - C16).

Uniprot Accession IDs

• Q9NV23
• Q5VUB6
• Q9NUW1

Gene Name

• OLAH

Ensembl ID

• ENST00000378217
• ENSP00000367462
• ENSG00000152463
• ENST00000378228
• ENSP00000367473

Symbol

• THEDC1
• TE2
• SAST
• AURA1
• THEDC1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.81
cell line	0.53
cellular component	0.5
cell type or tissue	0.46
trait	0.46

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.48   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 48   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.48   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 48   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0