You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
OLA1
Obg-like ATPase 1

Protein Summary
Description
Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP. This gene encodes a member of the GTPase protein family. The encoded protein interacts with breast cancer-associated gene 1 (BRCA1) and BRCA1-associated RING domain protein (BARD1), and is involved in centrosome regulation. Overexpression of this gene has been observed in multiple types of cancer and may be associated with poor survival. Pseudogenes of this gene have been defined on chromosomes 17 and 22. [provided by RefSeq, Jun 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000284719
  • ENSP00000284719
  • ENSG00000138430
  • ENST00000344357
  • ENSP00000340167
  • ENST00000428402
  • ENSP00000410385

Symbol
  • GTPBP9
  • DOC45
  • GBP45
  • GTBP9
  • GTPBP9
  • PTD004
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.99
molecular function
0.99
protein domain
0.92
transcription factor perturbation
0.91
histone modification site profile
0.87


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.91   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 264   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.91   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 264   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (247)
ALDOA
Tbio
Family:  Enzyme
Novelty:  0.00517474
Score:  0.913
Data Source:  STRINGDB
FGB
Tbio
Novelty:  0.00437751
Score:  0.912
Data Source:  STRINGDB
APP
Tclin
Novelty:  0.00008964
Score:  0.907
Data Source:  STRINGDB
SCCPDH
Tbio
Family:  Enzyme
Novelty:  0.06603568
Score:  0.907
Data Source:  STRINGDB
NHLRC2
Tbio
Novelty:  0.18676651
Score:  0.902
Data Source:  STRINGDB
VTI1B
Tbio
Novelty:  0.00955467
Score:  0.902
Data Source:  STRINGDB
APOOL
Tbio
Novelty:  0.08233023
Score:  0.902
Data Source:  STRINGDB
A2M
Tbio
Novelty:  0.00070446
Score:  0.902
Data Source:  STRINGDB
KNG1
Tbio
Novelty:  0.00007684
Score:  0.902
Data Source:  STRINGDB
FN1
Tchem
Novelty:  0.00003647
Score:  0.901
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Hemostasis (R-HSA-109582)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Hemostasis
Reactome
Platelet activation, signaling and aggregation
Reactome
Platelet degranulation
Reactome
Response to elevated platelet cytosolic Ca2+
Name
Explore in Pharos
Explore in Source
Hemostasis
Platelet activation, signaling and aggregation
Platelet degranulation
Response to elevated platelet cytosolic Ca2+
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (17)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HGNC
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-UniRule
Inferred from Electronic Annotation (IEA)
UniProtKB-UniRule
Disease Associations (null)
No disease associations found
GWAS Traits (24)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
3
3
3
78.5
educational attainment
1
3
3
76.3
blood protein measurement
1
1
1
69.1
C-reactive protein measurement
3
3
4
65.3
systolic blood pressure
2
2
2
63.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
3
78.5
educational attainment
3
76.3
blood protein measurement
1
69.1
C-reactive protein measurement
4
65.3
systolic blood pressure
2
63.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (17)
1 – 5 of 17
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Obg like ATPase 1
VGNC:14333
459751
Macaque
Obg like ATPase 1
697309
Mouse
MGI:1914309
67059
Rat
RGD:1307982
296488
Dog
Obg like ATPase 1
VGNC:44112
478803
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Obg like ATPase 1
Macaque
Obg like ATPase 1
Mouse
Rat
Dog
Obg like ATPase 1
Publication Statistics
PubMed Score 42.91
PubMed score by year
PubTator Score 16.58
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title