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Tbio
OIP5
Protein Mis18-beta

Protein Summary
Description
Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. The protein encoded by this gene localizes to centromeres, where it is essential for recruitment of CENP-A through the mediator Holliday junction recognition protein. Expression of this gene is upregulated in several cancers, making it a putative therapeutic target. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000220514
  • ENSP00000220514
  • ENSG00000104147

Symbol
  • MIS18B
  • CT86
  • MIS18B
  • LINT-25
  • MIS18beta
  • hMIS18beta
  • 5730547N13Rik
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.87
virus perturbation
0.68
transcription factor binding site profile
0.64
tissue sample
0.58
gene perturbation
0.55


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.36   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 96   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.36   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 96   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (270)
MIS18A
Tbio
Novelty:  0.08143008
p_int:  1
Score:  0.989
Data Source:  BioPlex,Reactome,STRINGDB
CEP170
Tbio
Novelty:  0.05342931
p_int:  0.999999995
p_ni:  5e-9
Data Source:  BioPlex
STX1A
Tbio
Novelty:  0.00087207
p_int:  0.999989679
p_ni:  0.000010291
p_wrong:  3e-8
Score:  0.193
Data Source:  BioPlex,STRINGDB
TRAF7
Tbio
Family:  Enzyme
Novelty:  0.02437761
p_int:  0.999979523
p_ni:  0.000019824
p_wrong:  6.54e-7
Data Source:  BioPlex
GTF2E2
Tbio
Novelty:  0.18033153
p_int:  0.999975003
p_ni:  0.000024939
p_wrong:  5.8e-8
Data Source:  BioPlex
MIS18BP1
Tbio
Novelty:  0.05688807
p_int:  0.999860708
p_ni:  0.000139279
p_wrong:  1.3e-8
Score:  0.995
Data Source:  BioPlex,Reactome,STRINGDB
S100A4
Tchem
Novelty:  0.00136919
p_int:  0.999840441
p_ni:  0.000159337
p_wrong:  2.22e-7
Data Source:  BioPlex
MED29
Tbio
Family:  Enzyme
Novelty:  0.01740647
p_int:  0.999587127
p_ni:  0.000412861
p_wrong:  1.2e-8
Data Source:  BioPlex
G0S2
Tbio
Novelty:  0.02273959
p_int:  0.997858902
p_ni:  0.000420439
p_wrong:  0.001720659
Data Source:  BioPlex
PIP
Tbio
Novelty:  0.00208509
p_int:  0.995787728
p_ni:  0.000287674
p_wrong:  0.003924598
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Chromosome Maintenance
Reactome
Deposition of new CENPA-containing nucleosomes at the centromere
Reactome
Nucleosome assembly
Name
Explore in Pharos
Explore in Source
Cell Cycle
Chromosome Maintenance
Deposition of new CENPA-containing nucleosomes at the centromere
Nucleosome assembly
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
leukocyte count
1
1
1
46.5
eosinophil percentage of leukocytes
1
1
1
42.3
lifestyle measurement
1
1
1
31.4
cognitive function measurement
1
1
1
27.3
self reported educational attainment
1
1
1
27.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
leukocyte count
1
46.5
eosinophil percentage of leukocytes
1
42.3
lifestyle measurement
1
31.4
cognitive function measurement
1
27.3
self reported educational attainment
1
27.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Opa interacting protein 5
VGNC:1902
453347
Mouse
MGI:1917895
70645
Dog
Opa interacting protein 5
VGNC:44111
100856061
Cow
Opa interacting protein 5
VGNC:32415
511100
Pig
Opa interacting protein 5
100516409
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Opa interacting protein 5
Mouse
Dog
Opa interacting protein 5
Cow
Opa interacting protein 5
Pig
Opa interacting protein 5
Publication Statistics
PubMed Score 41.36
PubMed score by year
PubTator Score 22.38
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title