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Tchem
OGG1
N-glycosylase/DNA lyase

Protein Summary
Description
DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion. This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined. [pro ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302003
  • ENSP00000305584
  • ENSG00000114026
  • ENST00000302008
  • ENSP00000305527
  • ENST00000302036
  • ENSP00000306561
  • ENST00000339511
  • ENSP00000345520
  • ENST00000344629
  • ENSP00000342851
  • ENST00000349503
  • ENSP00000303132
  • ENST00000383826
  • ENSP00000373337
  • ENST00000449570
  • ENSP00000403598

Symbol
  • MMH
  • MUTM
  • OGH1
  • HMMH
  • MUTM
  • OGH1
  • HOGG1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease
0.95
biological process
0.91
molecular function
0.91
disease perturbation
0.87
histone modification site profile
0.83


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1475.35   (req: < 5)
Gene RIFs: 426   (req: <= 3)
Antibodies: 428   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1475.35   (req: >= 5)
Gene RIFs: 426   (req: > 3)
Antibodies: 428   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 7
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (7)
Protein-Protein Interactions (140)
APLNR
Tchem
Family:  GPCR
Novelty:  0.00224203
p_int:  0.880404019
p_ni:  0.000004181
p_wrong:  0.1195918
Score:  0.203
Data Source:  BioPlex,STRINGDB
APEX1
Tchem
Family:  Enzyme
Novelty:  0.00037532
Score:  0.995
Data Source:  Reactome,STRINGDB
NEIL1
Tbio
Family:  Enzyme
Novelty:  0.00683956
Score:  0.99
Data Source:  Reactome,STRINGDB
NEIL2
Tbio
Family:  Enzyme
Novelty:  0.01124634
Score:  0.983
Data Source:  STRINGDB
XRCC1
Tbio
Novelty:  0.00084203
Score:  0.968
Data Source:  STRINGDB
NTHL1
Tbio
Family:  Enzyme
Novelty:  0.00769394
Score:  0.953
Data Source:  STRINGDB
MUTYH
Tbio
Family:  Enzyme
Novelty:  0.00137239
Score:  0.939
Data Source:  STRINGDB
FEN1
Tchem
Family:  Enzyme
Novelty:  0.00082515
Score:  0.921
Data Source:  STRINGDB
UNG
Tbio
Family:  Enzyme
Novelty:  0.00268354
Score:  0.903
Data Source:  STRINGDB
XRCC3
Tbio
Novelty:  0.00266163
Score:  0.89
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (14)
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway (R-HSA-5649702)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
Reactome
Base Excision Repair
Reactome
Base-Excision Repair, AP Site Formation
Reactome
Cleavage of the damaged purine
Reactome
Cleavage of the damaged pyrimidine
Name
Explore in Pharos
Explore in Source
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
Base Excision Repair
Base-Excision Repair, AP Site Formation
Cleavage of the damaged purine
Cleavage of the damaged pyrimidine
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (31)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
8-oxoguanine DNA glycosylase
VGNC:12109
460152
Macaque
8-oxoguanine DNA glycosylase
700481
Mouse
MGI:1097693
18294
Rat
RGD:621168
81528
Dog
8-oxoguanine DNA glycosylase
VGNC:44109
484666
Species
Name
OMA
EggNOG
Inparanoid
Chimp
8-oxoguanine DNA glycosylase
Macaque
8-oxoguanine DNA glycosylase
Mouse
Rat
Dog
8-oxoguanine DNA glycosylase
Publication Statistics
PubMed Score 1475.35
PubMed score by year
PubTator Score 908.54
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title