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Tbio
OGFOD1
Prolyl 3-hydroxylase OGFOD1

Protein Summary
Description
Prolyl 3-hydroxylase that catalyzes 3-hydroxylation of 'Pro-62' of small ribosomal subunit uS12 (RPS23), thereby regulating protein translation termination efficiency. Involved in stress granule formation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000566157
  • ENSP00000457258
  • ENSG00000087263

Symbol
  • KIAA1612
  • TPA1
  • TPA1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.95
histone modification site profile
0.86
molecular function
0.76
tissue sample
0.67
transcription factor binding site profile
0.67


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.78   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 154   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.78   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 154   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (68)
FNTA
Tclin
Family:  Enzyme
Novelty:  0.03163169
p_int:  0.999999807
p_ni:  1.83e-7
p_wrong:  1e-8
Data Source:  BioPlex
FGL1
Tbio
Novelty:  0.02650803
p_int:  0.999392736
p_ni:  0.000001298
p_wrong:  0.000605966
Score:  0.187
Data Source:  BioPlex,STRINGDB
RPS23
Tbio
Novelty:  0.01846154
Score:  0.8
Data Source:  STRINGDB
OGFOD2
Tdark
Family:  Enzyme
Novelty:  0.70711512
Score:  0.749
Data Source:  STRINGDB
GCN1
Tbio
Novelty:  0.02721216
Score:  0.726
Data Source:  STRINGDB
TMA16
Tdark
Novelty:  0.89810617
Score:  0.708
Data Source:  STRINGDB
G3BP1
Tbio
Family:  Enzyme
Novelty:  0.00589987
Score:  0.642
Data Source:  STRINGDB
P3H1
Tbio
Family:  Enzyme
Novelty:  0.02067711
Score:  0.641
Data Source:  STRINGDB
ALOX5
Tclin
Family:  Enzyme
Novelty:  0.00062988
Score:  0.632
Data Source:  STRINGDB
RIOX2
Tbio
Family:  Epigenetic
Novelty:  0.03254245
Score:  0.614
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
2
4
4
95.2
apolipoprotein A 1 measurement
2
5
5
90.7
body mass index
1
1
1
47.7
urate measurement
1
1
1
15.8
1
1
1
4.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
4
95.2
apolipoprotein A 1 measurement
5
90.7
body mass index
1
47.7
urate measurement
1
15.8
1
4.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
2-oxoglutarate and iron dependent oxygenase domain containing 1
VGNC:10130
454101
Macaque
2-oxoglutarate and iron dependent oxygenase domain containing 1
700219
Mouse
MGI:2442978
270086
Rat
RGD:1308848
307657
Dog
2-oxoglutarate and iron dependent oxygenase domain containing 1
VGNC:44105
478122
Species
Name
OMA
EggNOG
Inparanoid
Chimp
2-oxoglutarate and iron dependent oxygenase domain containing 1
Macaque
2-oxoglutarate and iron dependent oxygenase domain containing 1
Mouse
Rat
Dog
2-oxoglutarate and iron dependent oxygenase domain containing 1
Publication Statistics
PubMed Score 59.78
PubMed score by year
PubTator Score 25.78
PubTator score by year
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Related Publications
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PMID
Year
Title